Share：
Share this content in WeChat
X
[Chinese][PDF]66878
• Review •
The mechanisms of iron abnormal deposition and research progressive in the brains of patients with multiple sclerosis
DU Si-lin  LI Yong-mei 

DOI:10.3969/j.issn.1674-8034.2012.04.012.


[Abstract] Histology has showed iron abnormal deposition in the brains of patients with multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) animals. Iron in the brain can be detected and measured accurately using non-invasive magnetic resonance imaging (MRI). The probable pathogenesis and the related to experimental research on the brain iron abnormal deposition in MS patients and animal experiments are reviewed.
[Keywords] Multiple sclerosis；Encephalomyelitis, experimental autoimmune；Magnetic resonance imaging；Iron；Review literature

DU Si-lin Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

LI Yong-mei * Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

*Correspondence to: Li YM, E-mail: lymzhang70@yahoo.com

Conflicts of interest   None.

Received  2011-05-24
Accepted  2012-06-20
DOI: 10.3969/j.issn.1674-8034.2012.04.012
DOI:10.3969/j.issn.1674-8034.2012.04.012.

[1]
Stankiewicz J, Panter SS, Neema M. Iron in chronic brain disorders: imaging and neurotherapeutic implications. Neurotherapeutics, 2007, 4(3): 371-386.
[2]
Le Vine SM, Chakrabarty A. The role of iron in the pathogenesis of experimental allergic encephalomyelitis and multiple sclerosis. Ann NY Acad Sci, 2004, 1012: 52-66.
[3]
Haacke EM, Makki M, Ge Y. characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging. J Magn Reson Imaging, 2009, 29(3): 537-544.
[4]
Chen X, Zeng C, Luo TY, et al. Iron deposition of the deep grey matter in patients with multiple sclerosis and neuromyelitis optica: a control quantitative study by 3D-enhanced susceptibility-weighted angiography (ESWAN). Eur J Radiol, 2012, 81(4): e633-e639.
[5]
曾春，李咏梅，罗天友, 等. 三维增强T2*加权血管成像对多发性硬化脑内病灶铁沉积的分析. 中华放射学杂志, 2011, 45(12): 1166-1170.
[6]
苗延巍，魏强，韩睿, 等. 多发性硬化斑块周围正常表现白质的磁敏感加权成像及动态磁敏感增强灌注成像.磁共振成像, 2011, 2(4): 273-277.
[7]
张海琴，李坤成，于春水, 等. 实验性自身免疫性脑脊髓炎巨噬细胞活性MR成像的研究进展. 医学影像学杂志, 2007, 17(4): 402-404.
[8]
Ge Y, Jensen JH, Lu H, et al. Quantitative assessment of iron accumulation in the deep gray matter of multiple sclerosis by magnetic field correlation imaging. AJNR Am J Neuroradiol, 2007, 28(9): 1639-1644.
[9]
Singh AV, Zamboni P. Anomalous venous blood flow and iron deposition in multiple sclerosis. J Cereb Blood Flow Metab, 2009, 29(12), 1867-1878.
[10]
Williams R, Buchheit CL, Berman NE, et al. Pathogenic implication of iron accumulation in multiple sclerosis. J Neurochem, 2012, 120(1): 7-25.
[11]
Pelizzoni I, Macco R, Morini MF, et al. Iron handling in hippocampal neurons: activity-dependent iron entry and mitochondria-mediated neurotoxicity. Aging cell, 2011, 10(1): 172-183.
[12]
Zhu WZ, Zhong WD, Wei W. Quantitative MR Phase-corrected imaging to investigate increased brain iron deposition of patients with Alzheimer disease. Radiology, 2009, 253(2): 497-503.
[13]
Brar S, Henderson D, Schenck J, et al. Iron accumulation in the substantia nigra of patients with Alzheimer disease and parkinsonism. Arch Neurol, 2009, 66(3): 371-374.
[14]
Kalman B, Laitinen K, Komoly S, et al. The involvement of mitochondria in the pathogenesis of multiple sclerosis. J Neuroimmunol, 2008, 188(1-2): 1-12.
[15]
Zamboni P. The big idea: iron dependent inflammation in venous disease and proposed parallels in multiple sclerosis. J R Soc Med, 2006, 99(11): 589-593.
[16]
Zivadinov R, Ramanathan M, Dolic K, et al. Chronic cerebrospinal venous insufficiency in multiple sclerosis: diagnostic, pathogenetic, clinical and treatment perspectives. Neurotherapeutics, 2011, 11(9): 1277-1294.
[17]
Adams CW. Perivascular iron deposition and other vascular damage in multiple sclerosis. J Neurol Neurosurg Psychiatry, 1988, 51(2): 260-265.
[18]
Worthington V, Killestein J, Eikelenboom MJ. Normal CSF ferritin levels in MS suggest against etiologic role of chronic venous insufficiency. Neurology, 2010, 75(18): 1617-1622.
[19]
Williams R, Rohr AM, Wang WT, et al. Iron deposition is independent of cellular inflammation in a cerebral model of multiple sclerosis. BMC Neuroscience, 2011, 12:59.
[20]
Zivadinov R, Weinstock-Guttman B, Pirko I. Iron deposition and inflammation in multiple sclerosis. Which one comes first? BMC Neuroscience, 2011, 12:60.
[21]
Bowern N, Ramshaw IA, Clark IA, et al. Inhibition of autoimmune neuropathological process by treatment with an iron-chelating agent. J Exp Med, 1984, 160(5): 1532-1543.

PREV Radiographic progression of joint system in Radiological Society of North America 2011
NEXT The research status of non-enhanced MR angiography in peripheral arteries
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn