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• Clinical Article •
T2 hyperintensities in the brain with the neurofibromatosis type 1
FU Lin  WANG Zhen-chang  LI Jing  XIAN Jun-fang  ZHANG Zheng-yu 

DOI:10.3969/j.issn.1674-8034.2012.05.003.


[Abstract] Objective: The aim of this study was to review the clinical value of the hyperintensity on T2WI (T2H) located within brain tissue in patients with NF1 (neurofibromatosis type 1, NF1).Materials and Methods: We retrospectively analyzed the hyperintensity on T2WI located within brain tissue in 78 patients with neurofibromatosis type 1 (NF1), the morbidity, signal characteristics and localization of T2H were studied and statistical analyzed. The age of patients ranged from 2 to 60 years.Results: The T2H was observed in 55 NF1 patients on the brain MR images, the morbidity was 70.5% (55/78). The T2H were seen in 80.8% (42/52) of children and adolescent patients aged 2—18 years and 50.0% (13/26) of the adults (more than 18 years) with NF1, the results showed statistically significant difference between children and adolescent patients and adult patients (χ2=7.892, P=0.005). Most T2H was observed in the brainstem (65.5%, 36/55), cerebellum (58.2%, 32/55), basal ganglia (49.1%, 27/55), hippocampal (25.5%, 14/55)and thalamic (20%, 11/55). The T2H of patients aged 2—18 years located in brainstem (30 cases), cerebellum (29 cases), basal ganglia (22 cases), hippocampal (10 cases) and thalamic (9 cases), respectively. In patients over than 18 years, the T2H in the corresponding location was found in 6 cases, 3 cases, 5 cases, 4 cases and 2 cases. There were no significant difference about the location of T2H between adolescent and adult patients (χ2=2.738, P=0.603). In all positive patients, 74.1% (20/27) of the T2H on the basal ganglia was discrete, The majority of lesions on the other locations were diffuse, the frequency of the T2H on the brainstem was 77.8% (28/36), the cerebellum was 90.6% (29/32) and the thalamic was 81.8% (9/11). Most lesions were multiple.Conclusion: The T2H are most frequent intracranial appearance in individuals with neurofibromatosis type 1, especially in adolescents.Objective: The aim of this study was to review the clinical value of the hyperintensity on T2WI (T2H) located within brain tissue in patients with NF1 (neurofibromatosis type 1, NF1). Materials and Methods: We retrospectively analyzed the hyperintensity on T2WI located within brain tissue in 78 patients with neurofibromatosis type 1 (NF1), the morbidity, signal characteristics and localization of T2H were studied and statistical analyzed. The age of patients ranged from 2 to 60 years. Results: The T2H was observed in 55 NF1 patients on the brain MR images, the morbidity was 70.5% (55/78). The T2H were seen in 80.8% (42/52) of children and adolescent patients aged 2—18 years and 50.0% (13/26) of the adults (more than 18 years) with NF1, the results showed statistically significant difference between children and adolescent patients and adult patients (χ2=7.892, P=0.005). Most T2H was observed in the brainstem (65.5%, 36/55), cerebellum (58.2%, 32/55), basal ganglia (49.1%, 27/55), hippocampal (25.5%, 14/55)and thalamic (20%, 11/55). The T2H of patients aged 2—18 years located in brainstem (30 cases), cerebellum (29 cases), basal ganglia (22 cases), hippocampal (10 cases) and thalamic (9 cases), respectively. In patients over than 18 years, the T2H in the corresponding location was found in 6 cases, 3 cases, 5 cases, 4 cases and 2 cases. There were no significant difference about the location of T2H between adolescent and adult patients (χ2=2.738, P=0.603). In all positive patients, 74.1% (20/27) of the T2H on the basal ganglia was discrete, The majority of lesions on the other locations were diffuse, the frequency of the T2H on the brainstem was 77.8% (28/36), the cerebellum was 90.6% (29/32) and the thalamic was 81.8% (9/11). Most lesions were multiple. Conclusion: The T2H are most frequent intracranial appearance in individuals with neurofibromatosis type 1, especially in adolescents.
[Keywords] Genes, neurofibromatosis 1；Magnetic resonance imaging；Brain

FU Lin Department of Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

WANG Zhen-chang* Department of Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

LI Jing Department of Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

XIAN Jun-fang Department of Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

ZHANG Zheng-yu Department of Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

*Correspondence to: Wang ZC, E-mail: cjr.wzhch@vip.163.com

Conflicts of interest   None.

Received  2012-07-20
Accepted  2012-08-20
DOI: 10.3969/j.issn.1674-8034.2012.05.003
DOI:10.3969/j.issn.1674-8034.2012.05.003.

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