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• Clinical Article •
Assessment of extraocular muscle involvement in Graves ophthalmopathy by using dynamic contrast-enhanced MR imaging
JIANG Hong  WANG Zhen-chang  XIAN Jun-fang  LI Jing  AI Li-kun 

DOI:10.3969/j.issn.1674-8034.2012.05.005.


[Abstract] Objective: To assess EOMs involvement in GO by using DCE-MRI.Materials and Methods: EOMs of 50 patients with GO and 30 healthy controls were studied. Muscle cross-sectional area was measured on coronal T2W images. The image plane with the maximum cross-sectional area of each EOM was designated as segment Smax, one slice anterior to Smax was designated as Spre, and one slice posterior to Smax designated as Spost. The region of interest was placed on EOMs of different segments (Smax, Spre, and Spost) on coronal DCE-MRI. The DCE-MRI parameters, including time to peak enhancement (Tpeak), enhancement ratio (ER), and washout ratio (WR), were calculated.Results: There was no side difference in Tpeak, ER, and WR values of EOMs in patients with GO (P>0.05). Tpeak values in segment Smax was significantly higher than that in segment Spre and Spost (P=0.000), and ER, WR values were significantly lower than those in segment Spre and Spost (P=0.000). There was no significant difference in Tpeak, ER, and WR values between the superior and the inferior rectus (P>0.05). Tpeak values of the medial rectus, lateral rectus, and the superior oblique muscle were significantly lower than that of the inferior rectus (P<0.05). ER and WR values were significantly higher than those of the inferior rectus (P<0.05). The Tpeak was positively correlated with the cross-sectional area (P<0.01), and the ER and WR were negatively correlated with the cross-sectional area (P<0.01).Conclusion: The superior and the inferior rectus in the segment with the maximum cross-sectional area were most prominently involved in GO, which could offer objective quantitative data for assessing EOMs involvement.
[Keywords] Graves’disease；Extraocular muscle；Magnetic resonance imaging

JIANG Hong Department of Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

WANG Zhen-chang * Department of Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

XIAN Jun-fang Department of Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

LI Jing Department of Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

AI Li-kun Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

*Correspondence to: Wang ZC, E-mail: cjr.wzhch@vip.163.com

Conflicts of interest   None.

Received  2012-07-20
Accepted  2012-08-20
DOI: 10.3969/j.issn.1674-8034.2012.05.005
DOI:10.3969/j.issn.1674-8034.2012.05.005.

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