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• Clinical Article •
Characteristic findings of dynamic contrast enhancement magnetic resonance imaging in proliferative diabetic retinopathy
XU Qing-gang  CHEN Qing-hua  XIAN Jun-fang  WANG Zhen-chang 

DOI:10.3969/j.issn.1674-8034.2012.05.006.


[Abstract] Objective: Magnetic resonance imaging, employing dynamic contrast enhancement MRI (DCE-MRI), was used to detect changes in blood-retinal barrier (BRB) damage in patients with diabetes, which contributed to diabetic retinopathy and highlighted new information available from such applications.Materials and Methods: Seven participants were proliferative diabetic retinopathy (PDR) who were 3 males, 4 females, mean age (54±14) years, mean duration of diabetes (9±4) years and 14 examined eyes, as well as 14 non-diabetic individuals of similar age who were 7 males, 7 females, mean age (50±15) years and 16 examined eyes. Images were obtained using a 1.5 T GE scanner system. And after obtaining ophthalmologic data, dynamic contrast enhancement MRI was applied for detecting BRB damage in patients with diabetes. Data were analyzed with NIH IMAGE software. Preretinal vitreous water signals were used for data analysis statistically.Results: (1) The mean of the slope (the enhancement of the MRI signal to the time after contrast injection) in the control group was-0.0457±0.1129. The mean of the slope in PDR group was 0.4393±0.2697, which was significantly higher (P<0.05) than the control group. (2) During the delayed scans the BRB leakage demonstrated clearly a gradient of high signal intensity inside the vitreous which spread with time, related to a large diffusion of paramagnetic contrast. (3) The time-intensity curve of dynamic contrast enhancement in the BRB leakage suggested a pattern with sustained enhancement.Conclusion: These results revealed that DCE-MRI can be used to detect BRB damages in diabetic retinopathy. Wide application of this technique for diagnosis and evaluation of treatment efficacy in diabetic retinopathy is expected.
[Keywords] Magnetic resonance imaging；Diabetic retinopathy

XU Qing-gang Department of Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

CHEN Qing-hua Department of Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

XIAN Jun-fang Department of Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

WANG Zhen-chang* Department of Medical Imaging Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

*Correspondence to: Wang ZC, E-mail: cjr.wzhch@vip.163.com

Conflicts of interest   None.

Received  2012-07-20
Accepted  2012-08-20
DOI: 10.3969/j.issn.1674-8034.2012.05.006
DOI:10.3969/j.issn.1674-8034.2012.05.006.

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