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• Clinical Article •
Quantitative measurement of ADC value and T2 value in diagnosis of cervical lymphoma at 3.0 T MRI
GONG Hong-xia  LU Qing  ZHU Jiong  FAN Yu  XU Jian-rong 

DOI:10.3969/j.issn.1674-8034.2012.05.010.


[Abstract] Objective: This study was designed to compare the value of quantitative measurement of ADC value and T2 value in diagnosis of lymphoma at 3.0 T MRI.Materials and Methods: Twenty-four cervical lymphoma patients (incipient group) characterized by superficial lymph node enlargement and 24 healthy volunteers were studied. Twenty-four cervical lymphoma patients performed MRI examination and quantitative measurement again after 3 months normal treatment. Imaging were performed on a 3.0 T MR imaging system. The measurements of ADC value and T2 value were performed from trace ADC maps and T2 maps by placing regions of interest (ROI) over the cervical lymph nodes. Comparison between groups with LSD test.Results: Either lymphoma patients or normal control,all lymph nodes showed high intensity on DWI images and low intensity on ADC maps. On T2 value image the lymph nodes showed high intensity in all different TE value images , median intensity onT2 map. The ADC value and T2 value among incipient group, posttreatment group and normal control were (745.92±109.74)×10-6 mm2/s and (87.18±9.35) ms, (1303.97±276.59)×10-6 mm2/s and (93.30±11.21) ms, (1116.91±82.08)×10-6 mm2/s and (96.44±4.40) ms. There were significant statistical difference among all of them except for T2 value between posttreatment group and normal control. The optimal threshold ADC value and T2 value for differentiating normal and malignant cervical lymph nodes determined by ROC curve analysis were showed 1003.065×10-6 mm2/s and 90.92 ms . Applying this value resulted in a sensitivity of 100% and 62.5%, a specificity of 91.7% and 91.7%.Conclusion: The quantitative measurements of ADC value and T2 value at 3.0T MRI were important indicator in diagnosis of cervical lymphoma.The diagnostic sensitivity and specificity of ADC value was superior to T2 value.
[Keywords] Head and neck neoplasms；Lymphoma；Magnetic resonance imaging, Diffusion

GONG Hong-xia Department of Radiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

LU Qing Department of Radiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

ZHU Jiong Department of Radiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

FAN Yu Department of Radiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

XU Jian-rong * Department of Radiology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

*Correspondence to: Xu JR, E-mail: xujianr@hotmail.com

Conflicts of interest   None.

Received  2012-04-24
Accepted  2012-06-30
DOI: 10.3969/j.issn.1674-8034.2012.05.010
DOI:10.3969/j.issn.1674-8034.2012.05.010.

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