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• Clinical Article •
Preliminary study of DTI in the early diagnosis of cirrhosis patients with spinal cord lesions
NIU Jin-liang  HUANG Chun-yao  WANG Jun  TIAN Xue 

DOI:10.3969/j.issn.1674-8034.2012.05.013.


[Abstract] Objective: To investigate the value of early diagnosis of the average diffusion coefficient (DCavg) and fractional anisotropy (FA) of the magnetic resonance diffusion tensor imaging (DTI) in hepatic cirrhosis patients with spinal cord lesions.Materials and Methods: According to the standard of Child-Pugh classification, select A, B and C-class (group) patients (15 cases respectively) and 15 cases of normal healthy volunteers as controls (Group D). All the subjects accept thoracolumbar spinal DTI scan, b=500 s/mm2, 25 different directions of diffusion gradient. Reconstruct the DCavg and FA pseudo-color pictures by the post-processing of raw data and measure its value. Analysis of variance is used for the comparison of A, B, C, D group, the Bonferroni is used for the multiple comparison between groups, t test is used for the comparison between the control group and the hepatic cirrhosis group.Results: The value of DCavg of thoracolumbar spinal in normal control group (15 cases) is (1.330±0.160) ×10-3 mm2/s, the value of FA is 0.320±0.150, the value of DCavg of thoracolumbar spinal in hepatic cirrhosis group (45 cases) is (1.415±0.250) × 10-3 mm2/s, the value of FA is 0.404±0.110, the difference of the value of DCavg and FA between the two groups are significant (t=4.896, P<0.05, t=16.456, P<0.05). The value of DCavg of thoracolumbar spinal cord in A, B, C group are respectively (1.342±0.100) ×10-3 mm2/s, (1.371±0.230) ×10-3 mm2/s, (1.492±0.290) ×10-3 mm2/s, the value of FA are respectively 0.353±0.110, 0.385±0.130, 0.446±0.090. The difference of the value of DCavg and FA among the groups is significant (P<0.05). The value of DCavg and FA in group C are higher than the Group A, B and D, the difference is significant (P<0.05). The difference of the value of DCavg and FA between Group A and D is no significant difference (P>0.05).Conclusions: Compared with the normal, the value of DTI DCavg and FA of thoracolumbar spinal cord values in patients with hepatic cirrhosis is higher, the DTI could provide more information for the early diagnosis and condition assessment in hepatic cirrhosis patients with spinal cord lesions.
[Keywords] Spinal cord diseases；Magnetic resonance imaging；Diffusion；Liver cirrhosis

NIU Jin-liang Department of Radiology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China

HUANG Chun-yao Department of Radiology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China

WANG Jun * Department of Radiology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China

TIAN Xue Department of Radiology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China

*Correspondence to: WANG Jun, E-mail: cjr.wangjun@vip.163.com

Conflicts of interest   None.

Received  2012-04-05
Accepted  2012-07-06
DOI: 10.3969/j.issn.1674-8034.2012.05.013
DOI:10.3969/j.issn.1674-8034.2012.05.013.

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