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• Clinical Article •
Calculation ability in mild vascular cognitive impairment and normal aging: a functional magnetic resonance imaging study
XUE Yun-jing  ZHOU Zuo-fu  SU Yu-zheng  DUAN Qing 

DOI:10.3969/j.issn.1674-8034.2012.06.005.


[Abstract] Objective: To explore the difference of arithmetic calculation between the normal elders with non cognitive impairment and the patients with mild vascular cognitive impairment (MVCI) by functional magnetic resonance imaging (fMRI).Materials and Methods: Twenty-two patients with vascular cognitive impairment and 12 non-cognitive-disable elders were scanned by MRI when they performed calculation. Comparing the normal cognitive patients with MVCI group in situation of activated voxels by subtraction within 20 and in the laterality of functional areas in frontal lobe and parietal lobe by subtraction, as well as comparing the reaction time and accuracy by through behavior data.Results: During the subtraction task, the behavior data showed that accuracy rate in MVCI group was lower than normal one (χ2=18.6, P<0.001) and the reaction time in MVCI group was longer than the normal group (t=3.676, P<0.05). Compared to the normal group, the MVCI group exhibited hypo-activity in bilateral parietal lobe (inferior parietal lobule mainly), bilateral middle frontal gyrus, bilateral hippocampus, parahippocampal gyrus, right posterior cingulate gyrus, bilateral middle temporal gyrus, left inferior temporal gyrus, bilateral occipital and bilateral cerebellar (P<0.005). In subtraction, for both right handed groups, activation of functional areas of frontal and parietal lobe had the left laterality. In nomal group, the laterality index of parietal lobe was higher than that of frontal lobe, while in MVCI group it was on the contrary.Conclusion: The patients with MVCI has an insufficient in calculation ability and somehow compensation. The study of the calculation fMRI can offer a powerful reference for the diagnosis of MVCI.Objective: To explore the difference of arithmetic calculation between the normal elders with non cognitive impairment and the patients with mild vascular cognitive impairment (MVCI) by functional magnetic resonance imaging (fMRI). Materials and Methods: Twenty-two patients with vascular cognitive impairment and 12 non-cognitive-disable elders were scanned by MRI when they performed calculation. Comparing the normal cognitive patients with MVCI group in situation of activated voxels by subtraction within 20 and in the laterality of functional areas in frontal lobe and parietal lobe by subtraction, as well as comparing the reaction time and accuracy by through behavior data. Results: During the subtraction task, the behavior data showed that accuracy rate in MVCI group was lower than normal one (χ2=18.6, P<0.001) and the reaction time in MVCI group was longer than the normal group (t=3.676, P<0.05). Compared to the normal group, the MVCI group exhibited hypo-activity in bilateral parietal lobe (inferior parietal lobule mainly), bilateral middle frontal gyrus, bilateral hippocampus, parahippocampal gyrus, right posterior cingulate gyrus, bilateral middle temporal gyrus, left inferior temporal gyrus, bilateral occipital and bilateral cerebellar (P<0.005). In subtraction, for both right handed groups, activation of functional areas of frontal and parietal lobe had the left laterality. In nomal group, the laterality index of parietal lobe was higher than that of frontal lobe, while in MVCI group it was on the contrary. Conclusion: The patients with MVCI has an insufficient in calculation ability and somehow compensation. The study of the calculation fMRI can offer a powerful reference for the diagnosis of MVCI.
[Keywords] Cognition disorders；Magnetic resonance imaging；Mathematical computing

XUE Yun-jing * Department of Radiology, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, China

ZHOU Zuo-fu Department of Radiology, the Teaching Hospital of Fujian Medical University, Fujian Children and Women Hospital, Fuzhou 350001, China

SU Yu-zheng Department of Radiology, the Teaching Hospital of Fujian Medical University, Fujian Children and Women Hospital, Fuzhou 350001, China

DUAN Qing Department of Radiology, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, China

*Correspondence to: Xue YJ, E-mail: xueyunjing@126.com

Conflicts of interest   None.

Received  2012-09-13
Accepted  2012-10-28
DOI: 10.3969/j.issn.1674-8034.2012.06.005
DOI:10.3969/j.issn.1674-8034.2012.06.005.

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