Share：
Share this content in WeChat
X
[Chinese][PDF]98285
• Clinical Article •
Relationships between dynamic contrast-enhanced MRI, and pathological types and immunohistochemical findings of patients in breast cancer
ZHANG Qing  WANG Zhen-chang  XIAN Jun-fang  YAN Fei  LI Shu-ling 

DOI:10.3969/j.issn.1674-8034.2012.06.006.


[Abstract] Objective: The aim of the current study was to determine the relationships between contrast MRI and pathological types and histopathological findings of patients in breast cancer.Materials and Methods: Patients (n=33) who suspected breast cancer because of palpable mass or sonography were selected to perform MRI in preoperative phase. All patients were underwent breast tumor surgical resection or biopsy, definiting pathological type, and on postoperative specimens for immunohistochemical staining. Patient’s pathology type, receptor status (ER, PR, CD34 and p53), and lymph node status were recorded. These patients were all women, the mean age of them was 50.9±10.6 (ranging 25 to 71 years). MR examinations were performed with the patients prone in a 1.5 tesla commercially available system (Signa Infinity Excite Ⅱ, GE, USA) using a dedicated surface breast coil. Imaging sequences included line cross section T1WI, fat-suppressed T2WI, and the ipsilateral sagittal plane T2WI scanning. A ipsilateral sagittal fat-suppression dynamic contrast-enhanced T1WI acquisitions were performed before and twelve times after a rapid bolus injection of 0.1 mmol/L of Gd-DTPA per kilogram of body weight, then T1WI DCE-MRI was acquired. The maximal intensity projection reconstructions were extracted from the dynamic contrast-enhanced images. The time-signal intensity curves (TIC) of the dynamic enhancement MRI was obtained in a workstation. The measurement of the size of the tumor in the sagittal plane enhancement images were analyzed for each patient, including of MRI morphologic features, signal characteristics and the patterns of TIC. Chi-Square tests (Fisher exact test ) was used to comparing two-groups variable correlations.Results: Cases were classified into invasive ductal carcinoma (n=24) and non-invasive ductal carcinoma (n=9). There were 11 cases of axillary lymph node metastasis confirmed by pathology. Statistical analysis showed that lesions long path in MRI was correlated with p53 and lymph node metastasis confirmed by pathology, and axillary lymph node metastasis confirmed by pathology was correlated with p53 (P<0.01). If the patterns of TIC was categorized into platform-type and non-platform-type, it was correlated with the size of axillary lymph node in MRI (P<0.01). The pathological type of breast cancer was associated with CD34 (P<0.05).Conclusion: The contrast-enhanced MRI features of breast cancer seem to be associated with immunohistochemistry indicators.
[Keywords] Breast neoplasms；Magnetic resonance imaging；Pathology；Immunohistochemistry

ZHANG Qing Department of Radiology, Capital Medical University, Beijing Tongren Hospital, Beijing 100730, China

WANG Zhen-chang * Department of Radiology, Capital Medical University, Beijing Tongren Hospital, Beijing 100730, China

XIAN Jun-fang Department of Radiology, Capital Medical University, Beijing Tongren Hospital, Beijing 100730, China

YAN Fei Department of Radiology, Capital Medical University, Beijing Tongren Hospital, Beijing 100730, China

LI Shu-ling Department of Radiology, Capital Medical University, Beijing Tongren Hospital, Beijing 100730, China

*Correspondence to: Wang ZC, E-mail: cjr.wzhch@vip.163.com

Conflicts of interest   None.

Received  2012-06-26
Accepted  2012-09-07
DOI: 10.3969/j.issn.1674-8034.2012.06.006
DOI:10.3969/j.issn.1674-8034.2012.06.006.

[1]
Sommer CA, Stitzenberg KB, Tolleson-Rinehart S, et al. Breast mri utilization in older patients with newly diagnosed breast cancer. J Surg Res, 2011, 170(1): 77-83.
[2]
Lehman CD, Isaacs C, Schnall MD, et al. Cancer yield of mammography, MR, and US in high-risk women: prospective multi-institution breast cancer screening study. Radiology, 2007, 244(2): 381-388.
[3]
Kriege M, Brekelmans CT, Boetes C, et al. Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N Engl J Med, 2004, 351(5): 427-519.
[4]
Bluemke DA, Gatsonis CA, Chen MH, et al. Magnetic resonance imaging of the breast prior to biopsy. JAMA, 2004, 292(22): 2735-2742.
[5]
Lu H, Xu YL, Zhang SP, et al. Breast magnetic resonance imaging in patients with occult breast carcinoma: evaluation on feasibility and correlation with histopathological findings. Chin Med J, 2011, 124(12): 1790-1795.
[6]
Gutierrez RL, DeMartini WB, Silbergeld JJ, et al. High cancer yield and positive predictive value: outcomes at a center routinely using preoperative breast MRI for staging. AJR Am J Roentgenol, 2011, 196(1): W93-W99.
[7]
Biglia N, Mariani L, Sgro L, et al. Increased incidence of lobular breast cancer in women treated with hormone replacement therapy: implications for diagnosis, surgical and medical treatment. Endocr Relat Cancer, 2007, 14(3): 549-567.
[8]
Tuncbilek N, Karakas HM, Okten OO. Dynamic magnetic resonance imaging in determining histopathological prognostic factors of invasive breast cancers. Eur J Radiol, 2005, 53(2): 199-205.
[9]
Christian Sohns, Martin Scherrer, Wieland Staab, et al. Value of the BI-RADS classification in MR-Mammography for diagnosis of benign and malignant breast tumors. Eur Radiol, 2011, 21(12): 2475-2483.

PREV Calculation ability in mild vascular cognitive impairment and normal aging: a functional magnetic resonance imaging study
NEXT Diagnosis in 3.0 T MRI of infiltrating ductal carcinoma of breast
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn