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• Clinical Article •
Different b-value diffusion weighted imaging in differential diagnosis of upper urinary tract cancer and non-specific inflamation
WU Guang-yu  LU Qing  XU Jian-rong 

DOI:10.3969/j.issn.1674-8034.2012.06.009.


[Abstract] Objective: To investigate the value of ADC derived from different b-value diffusion-weighted imaging (DWI) in differentiating upper urinary tract cancer and non-specific inflamation.Materials and Methods: Twenty four patients with upper urinary tract tumor (malignant group) and 14 patients with non-specific inflamation (inflamation group) underwent DWI with different b value on a 3 T MR imaging scanner. The ADC values and SNR among different b factors were measured respectively and analyzed statistically, ADC value of upper urinary tract cancer and non-specific inflamation was compared using Mann-Whitney U test, ADC value derived from different b value was compared using Friedman analysis and SNR of DWI with different b value was compared using ANOVA test.Results: When ADC was derived from DWI with b value of 500, 1000, 1500, 2000 s/mm2, the mean ADC value of malignant group was (1.70±0.40), (1.46±0.36, (1.21±0.28), (1.04±0.21)×10-3 mm2/s, the mean ADC value of inflamation group was (2.47±0.83),(1.99±0.49), (1.76±0.43), (1.49±0.36)×10-3 mm2/s. An increase in b-value was associated with a decrease in ADC value in upper urinary tract cancer as well as in non-specific inflamation. The ADC value of upper urinary tract cancer was significantly lower than that of non-specific inflamation. The result of ROC analysis shows the differential abilitiy of b=1500, 2000 s/mm2 was significantly higher than b=500, 1000 s/mm2 and there was no obvious different both in b=2000 vs b=1500 s/mm2 and b=1000 vs b=500 s/mm2. The SNR of DWI was decreased with the increasing of b value. The most optimal b-value in dfferential diagnosis was observed with b=1500 s/mm2, the cut off value was 1.42×10-3 mm2/s, the sensitivity of differential diagnosis was 78.6% and the specificity was 79.2%.Conclusion: DWI with b=1500 s/mm2 is of promising value in differential diagnosis of upper urinary tract cancer and non-specific inflammation.
[Keywords] Urologic neoplasms；Inflammation；Magnetic resonance imaging, diffusion

WU Guang-yu# Department of Radiology, Renji Hospital, Medical College of Jiaotong University, Shanghai 200032, China

LU Qing# Department of Radiology, Renji Hospital, Medical College of Jiaotong University, Shanghai 200032, China

XU Jian-rong * Department of Radiology, Renji Hospital, Medical College of Jiaotong University, Shanghai 200032, China

#Both authors contributed equally to this work

*Correspondence to: Xu JR, E-mail: xujianr@hotmail.com

Conflicts of interest   None.

Received  2012-05-02
Accepted  2012-07-02
DOI: 10.3969/j.issn.1674-8034.2012.06.009
DOI:10.3969/j.issn.1674-8034.2012.06.009.

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