Share：
Share this content in WeChat
X
[Chinese][PDF]86583
• Review •
The metastasis relapse monitors hepatocellular carcinoma: diffusion weighted MR imaging and molecular biology technology research progress
LIU Xin-Jiang  WANG Bin 

DOI:10.3969/j.issn.1674-8034.2012.06.013.


[Abstract] Multi-treaments of hepatocellular carcinoma (HCC) place greater demands on follow-up for tumor response. Functional MRI (fMRI) which mainly contains MRS, DWI, and PWI, is a non-invasive technique which can detect regional and global alterations in liver metabolic processes and celluar energy states as well as blood flow. Continued progress in this field of liver imaging may have profound implications for diagnosing and estimating therapeutic effect of HCC. The metastasis of HCC has long been recognized as a multi-stepprocess that involves multiple factors. Insteadof diagnostic models based on single-moleculedetection, the combination of multiple molecules will be the trend for early tumor diagnosis or prediction of tumor metastasis and recurrence. Many differentially expressed metastasis-associatedgenes and proteins have been reported in HCC. The purpose of this review is to expond the principles of tin vivo hepatic f MRI, to examine its present place in the diagnostic assessment of tumor biological characteristics, to appraise the respone of the tumor to treament and to evalute the prospects for f MRI in application of prognostic tests of HCC. This article Involved in the transfer of liver cancer recurrence of novel molecular markers had peripheral blood.
[Keywords] Liver neoplasms；Neoplasms metastasis；Magnetic resonance imaging；Biological markers

LIU Xin-Jiang Binzhou Medical University Hospital, Binzhou 256603, China; Shandong University, School of Medicine, Jinan 250012, China

WANG Bin * Shandong University, School of Medicine, Jinan 250012, China; Binzhou Medical University, Binzhou 256603, China

*Correspondence to: Wang B, E-mail: binwang001@yahoo.com.cn

Conflicts of interest   None.

Received  2012-09-08
Accepted  2012-10-28
DOI: 10.3969/j.issn.1674-8034.2012.06.013
DOI:10.3969/j.issn.1674-8034.2012.06.013.

[1]
黄丙仓，詹松华，耿道颖, 等. 大鼠右肝门静脉结扎磁共振扩散加权成像, 磁共振成像, 2010, 1 (1): 55-59.
[2]
韩鸿宾，王俭，谢敬霞, 等. 高扩散敏感系数扩散加权像异常高信号疾病的鉴别诊断. 中华放射学杂志, 2002, 36 (9): 812-816.
[3]
Kim Tm Murakami T, Takahashi S. Diffusion-weighted single-shot echoplanar MR imaging for liver disease. Am J Roentgenol, 1999, 173(2): 393-398.
[4]
Taouli B, Vilgrain V, Dumont E. Evaluation of liver diffusion isotropy and characterization of focal hepatic lesions with two single-shot echo-planar MR imaging sequences:prospective study in 66 patients. Radiology, 2003, 226(1): 71-78.
[5]
Ichikawa T, Haradome H, Hachiya J. Diffusion-weighted MR imaging with a single-shot echoplanar sequence:detection and characterization of focal hepatic lesions. Am J Radiology, Roentgenol, 1998, 170(2): 397-402.
[6]
江新青，陈亮，魏新华, 等. 三维适形放疗后兔VX2肝癌MR灌注加权成像:与病理对照. 磁共振成像杂志, 2010, 1(2): 133-137.
[7]
Chenevert TL, McKeever PE, Ross BD. Monitoring early response of experimental brain tumors to therapy using diffusion magnetic resonance imaging. Clin Cancer Res, 1997, 3(9): 1457-1466.
[8]
Lyng H, Haraldseth O, Rofstad EK. Measurement of cell density and necrotic fraction in human melanoma xenografts by diffusion weighted magnetic resonance imaging. Magn Reson Med, 2000, 43(6): 828-836.
[9]
Geschwind JF, Artemov D, Abraham S. Chemoembolization of liver tumor in a rabbit model: assessment of tumor cell death with diffusion-weighted MR imaging and histologic analysis. J Vasc Interv Radiol, 2000, 11(10): 1245-1255.
[10]
Kamel IR, Bluemke DA, Ramsey D. Role of diffusion-weighted imaging in estimating tumor necrosis after chemoembolization of hepatocellular carcinoma. Am J Roentgenol, 2003, 181(3): 708-710.
[11]
Moteki T, Ishizaka H, Horikoshi H, et al. Differentiation between hemangiomas and hepatoce Uular carcinomas with the apparent diffusion coefficient calculated from turboFLASH MR images. J Magn Reson Imaging, 1995, 5(2): 187-191.
[12]
Kim T, Murakami T, Takahashi S, et al. Diffusion-weighted single-shot echoplanar MR imaging for liver disease. AJR Am J Roentgenol, 1999, 173(2): 393-398.
[13]
Sun Xi-jie, Liang Wen, Quan Xian-yue, et al. Quantitative study of mangnetic resonace imaging in focal hepatic lesionsless than 3 cm. J Hepatobil Surg, 2005, 13(2): 112-115.
[14]
Zhang YL, Sun XW, Qiang YQ. Clinical application of abdominal diffusion weighted MR imaging. J Prac Radiology, 2005, 21(3): 313-315.
[15]
徐贤，张金山，马林, 等. 3.0 T磁共振全身扩散加权成像的正常表现和初步临床研究. 2007, 23(6): 793-796.
[16]
丁光辉，王红阳，吴孟超, 等. GPC-3 mRNA在甲胎蛋白阴性肝癌中的表达及其意义. 中华实验外科杂志, 2001, 18(2): 112-113.
[17]
Zhu ZW, Friess H, Wang L, et al. Enhanced glypican-3 expression differentiates the majority of hepato-cellular carcinoma as from benign hepatic disorders. Gut, 2001, 48(4): 558-564.
[18]
柏凯，梁平. 原发性肝癌患者外周血GPC-3 mRNA的表达与微转移的关系. 消化外科, 2006, 5(2): 115-118.
[19]
Nakano M, Saito A, Yamamoto M, et al. Stromal and blood vessel wall invasion in well-differentiates hepatocellular carcinoma. Liver, 1997, 17(1): 41.
[20]
唐浩，梁平. 外周血GPC-3 mRNA在大鼠肝癌微转移中的意义. 消化外科, 2005, 4(1): 48-51.
[21]
Ding GH, Wang HY, Chen H, et al. Expression of the Glypican-3 Gene in α-fetoprotein-negative Human Hepatocellular Carcinoma. Chin-Germ J Clin Oncol, 2005, 4(5): 262-266.
[22]
郜玉峰，李旭，谢秀琴, 等. 骨桥蛋白和CD44在肝癌中的表达及意义. 中华肝脏病杂志, 2005, 13(3): 227-228.
[23]
Chen RX, Ye SL. Relationship between osteopontin-related moleculars and tumor metastasis. J Internat Pathol and Clin Med, 2006, 26(3): 209-212.
[24]
Man XB, Hu HP, Tang L, et al. Quantitative detection of osteopontin high expression in human and rat hepatocellular carcinoma. Chin-Germ J Clin Oncol, 2006, 5(2): 78-81.
[25]
崔伯康，张昌卿，张颖, 等. 骨桥蛋白检测对预测肝细胞癌转移复发的意义. 癌症, 2006, 25(7): 876-879.
[26]
陆建，卞建民，樊克武, 等. 肝癌中骨桥蛋白和血管内皮生长因子的表达及临床意义. 江苏医药, 2006, 32(5): 418-420.
[27]
Nguyen M, Watanabe H, Budson AE, et al. Elevated level of an angiegenic peptide basic fibroblast growth factor in the urine of patients with a wide spectrum of cancers. J Natl Cancer inst, 1994, 86(5): 356-361.
[28]
Nanus DM, Schmitz Drager BJ, Motor RJ, et al. Expression of basic fibroblast growth factor in primary human renal tumors: correlation with poor survival. J Natl cancer Inst, 1993, 85(19): 1597-1599.
[29]
Dirix LY, Vermeulen PB, Pawinski A, et al. Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients. Br J Cancer, 1997, 76(2): 238-243.
[30]
Barton DP, Cai A, Wendt K, et al. Angiogenic protein expression in advanced epithelial ovarian cancer. Clin Cancer Res, 1997, 3(9): 1579-1586.
[31]
Koga T, Shibahara K, Kabashima A, et al. Overexpression of cyclooxygenase-2 and tumor angiogenesis in human gastric cancer. Hepatogastroenterology, 2004, 51(60): 1626-1630.
[32]
Han R, Tsui S, Smith TJ. Up-regulation of prostaglandin E2 synthesis by interleukin-1beta in human orbital fibroblasts involves coordinate induction of prostaglandin-endoperoxide H synthase-2 and glutathione-dependent prostaglandin E2 synthase expression. Biol Chem, 2002, 277(19): 16355-16364.
[33]
Fuson AL, Komlosi P, Unlap TM, et al. Immunolocalization of a microsomal prostaglandin E synthase in rabbit kidney. Am J Physiol Renal Physiol, 2003, 285(3): 558-564.
[34]
Tavernarakis N, Wang SL, Dorovkov M, et al. Heritable and inducible genetic interference by double-stranded RNA encoded by transgenes. Nat Genet, 2000, 24(2): 180-183.
[35]
Kamei D, Murakami M, Nakatani Y, et al. Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis. Biol Chem, 2003, 278(21): 19396-19405.
[36]
Zweifel BS, Davis TW, Ornberg RL, et al. Direct evidence for a role of cyclooxygenase 2 drived prostaglandin E2 in human head and neck xenograft tumors. Cancer Res, 2002, 62 (22): 6706-6711.
[37]
Parker LH, Sehmidt M, Jin SW, et al. The endothelial-cell-derived secreted factor Egfl 7 regulates vascular tube formation. Nature, 2004, 428(6984): 754-758.
[38]
Pieuric S, Friedrich M, Oess S. Expression and purification of recombinant human EGFL 7 protein. Protein Expr Purif, 2009, 68(1): 1-6.
[39]
Schmidt MH, Bicker F, Nikalie I, et al. Epidermal growth factor like domain 7 (EGFL 7) modulates notch signalling and affects neural stem cell renewal. Nat Cell Boil, 2009, 11(7): 873-880.
[40]
陈克林，唐卫，丁玉霞, 等. 外周血中肝癌细胞转移的检测. 哈尔滨医科大学学报, 2000, 34(5): 367-370.
[41]
舒宏，康晓楠，刘银坤. 肝癌转移、复发预测的蛋白质分子标志物. 世界华人消化杂志, 2010, 18(13): 1350-1355.
[42]
蔡兵，鲁严，严承铨，吴鸣宇, 等. 甲胎蛋白信使核糖核酸(AFP mRNA)的检测方法及其临床意义. 苏州医学院院报, 2000, 20(10): 908-910.
[43]
Li D, Mallory T, Satomura S. AFP-L3: a new generation of tumor marker for hepatocelluar carcinoma. Clin Chin Acta, 2001, 313(2):15-19.
[44]
Ando E, Tanaka M, Yamashita F, et al. Diagnostic clues for recurrent hepatocelluar carcinoma coparison tumor markers and inagingstudies. Eur Gastroenterol Hepatol, 2003, 15(6): 641-648.
[45]
Podsypanina K, Du YC, Jechlinger M, et al. Seeding and propagation of untransformed mouse mammary cells in the lung. Science, 2008, 321(5879): 1841-1844.
[46]
任静，杨勇，王芳, 等. 前列腺干细胞抗原特异性MR分子探针体外成像实验研究. 磁共振成像, 2010, 1(2): 138-141.

PREV Syngo MR peripheral nerve imaging
NEXT MRI diagnosis of the case of multiple intra-spinal meningeoma
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn