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The metastasis relapse monitors hepatocellular carcinoma: diffusion weighted MR imaging and molecular biology technology research progress
LIU Xin-Jiang  WANG Bin 

DOI:10.3969/j.issn.1674-8034.2012.06.013.


[Abstract] Multi-treaments of hepatocellular carcinoma (HCC) place greater demands on follow-up for tumor response. Functional MRI (fMRI) which mainly contains MRS, DWI, and PWI, is a non-invasive technique which can detect regional and global alterations in liver metabolic processes and celluar energy states as well as blood flow. Continued progress in this field of liver imaging may have profound implications for diagnosing and estimating therapeutic effect of HCC. The metastasis of HCC has long been recognized as a multi-stepprocess that involves multiple factors. Insteadof diagnostic models based on single-moleculedetection, the combination of multiple molecules will be the trend for early tumor diagnosis or prediction of tumor metastasis and recurrence. Many differentially expressed metastasis-associatedgenes and proteins have been reported in HCC. The purpose of this review is to expond the principles of tin vivo hepatic f MRI, to examine its present place in the diagnostic assessment of tumor biological characteristics, to appraise the respone of the tumor to treament and to evalute the prospects for f MRI in application of prognostic tests of HCC. This article Involved in the transfer of liver cancer recurrence of novel molecular markers had peripheral blood.
[Keywords] Liver neoplasms；Neoplasms metastasis；Magnetic resonance imaging；Biological markers

LIU Xin-Jiang Binzhou Medical University Hospital, Binzhou 256603, China; Shandong University, School of Medicine, Jinan 250012, China

WANG Bin * Shandong University, School of Medicine, Jinan 250012, China; Binzhou Medical University, Binzhou 256603, China

*Correspondence to: Wang B, E-mail: binwang001@yahoo.com.cn

Conflicts of interest   None.

Received  2012-09-08
Accepted  2012-10-28
DOI: 10.3969/j.issn.1674-8034.2012.06.013
DOI:10.3969/j.issn.1674-8034.2012.06.013.

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