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• Clinical Article •
Dynamic functional MRI study of absence seizures
ZHANG Zhi-Qiang  XU Qiang  LU Guang-Ming  LIAO Wei  WANG Zheng-Ge  JIAO Qing 

ZHANG Zhi-qiang, and XU Qiang are the first authors who contributed equally to the article DOI:10.3969/j.issn.1674-8034.2013.01.002.


[Abstract] Objective: To study the dynamic activation during the progress of absence seizures using dynamic blood oxygenation level-dependent functional MRI (BOLD-fMRI) analysis.Materials and Methods: Seventeen sessions of simultaneous EEG and fMRI data were acquired from 12 children with absence seizures (AS). Sequential hemodynamic-response function based generalized linear model analysis and region-of-interest based time-course analysis were employed to investigate dynamic alterations of brain region during procedure of absence seizures.Results: The thalamus and widely distributed cortical structures were found to have significant BOLD alterations responding to the generalized-slow and wave discharges. BOLD response was found in the thalamus and cortex 18 seconds prior to generalized-slow and wave discharges. There were variable time points of maximal activation or deactivation in different brain regions.Conclusions: The thalamus activation is proposed to be linked to the generation of epileptic seizures, and the deactivation in the default-mode regions and the other wide cortical regions may be correlated with the consciousness impairments in seizures. This study contributed to the understanding of mechanism of impaired consciousness in AS. The finding of BOLD response prior to the GSWD supports the feasibility of seizure prediction.
[Keywords] Epilepsy, absence；Magnetic resonance imaging；Child

ZHANG Zhi-Qiang Department of Medical Imaging, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China

XU Qiang Department of Medical Imaging, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China

LU Guang-Ming* Department of Medical Imaging, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China

LIAO Wei Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China

WANG Zheng-Ge Department of Medical Imaging, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China

JIAO Qing Department of Medical Imaging, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China

*Correspondence to: Lu GM, E-mail: cjr.luguangming@vip.163.com

Conflicts of interest   None.

Received  2012-10-26
Accepted  2012-11-29
DOI: 10.3969/j.issn.1674-8034.2013.01.002
ZHANG Zhi-qiang, and XU Qiang are the first authors who contributed equally to the article DOI:10.3969/j.issn.1674-8034.2013.01.002.

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