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• Clinical Article •
Resting-state functional connectivity in patients with generalized tonic-clonic seizures
JI Gong-jun  LIAO Wei  ZHANG Zhi-qiang  LU Guang-ming 

DOI:10.3969/j.issn.1674-8034.2013.01.003.


[Abstract] Objective: To investigate the alteration of brain functional networks underlying normal brain organization in patients with generalized tonic-clonic seizures (GTCS) using seed-based resting-state fMRI functional connectivity analyses.Materials and Methods: Resting-state fMRI datasets were acquired from 52 GTCS patients during interictal period and 57 matched healthy controls. The bilateral thalamus and posterior cingulate cortex (PCC) selected as seed region. The averaged time series within each seed was used to detect brain regions with fMRI signal correlated with the seed.Results: Within group comparison using one sample t-test showed significant functional connectivity pattern in thalamic network and in default mode network (DMN). Compared to controls, bilateral thalamus showed increased functional connectivity with primary motor cortex and insula, while decreased functionalconnectivity were found in basal ganglia and DMN regions. Within DMN, decreased functional connectivity with bilateral PCC were found in bilateral temporal pole, medial prefrontal lobe and supramarginal gyrus, while increased regions were found in bilateral angular gyrus, thalamus and left superior frontal gyrus.Conclusions: Thalamus is a key node of the epileptic network in GTCS. The increased functional connectivity between thalamus and primary motor area may be associated with the tonic and clonic during seizures. Additionally, decreased functional connectivity in the DMN suggested default brain functional may also be impaired in GTCS, which may be related to the loss of consciousness during seizures. These results demonstrated the impairment of brain function in GTCS patients even in interictal state, and imporved our understanding of the pathophysiological mechanisms of GTCS.
[Keywords] Epilepsy, tonic-clonic seizures；Magnetic resonance imaging；Resting-state functional connectivity

JI Gong-jun State Key Laboratory of Cognitive Neuroscience and Learning, School of Brain and Cognitive Sciences, Beijing Normal University, Beijing 100875, China

LIAO Wei Center for Cognition and Brain Disorders and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 310015, China; Department of Medical Imaging, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China

ZHANG Zhi-qiang Department of Medical Imaging, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China

LU Guang-ming* Department of Medical Imaging, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China

*Correspondence to: Lu GM, E-mail: cjr.luguangming@vip.163.com

Conflicts of interest   None.

Received  2012-10-26
Accepted  2012-11-29
DOI: 10.3969/j.issn.1674-8034.2013.01.003
DOI:10.3969/j.issn.1674-8034.2013.01.003.

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