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• Clinical Article •
Magnetization transfer imaging study of idiopathic epilepsy at 3.0 T high field magnetic resonance scanner
LIU Xin-feng  CAO Yu-ping  OU Xin-wei  LIAO Da-wei  ZHANG Guo-ming  ZHU Ke-wen  PENG Lan  ZHANG Ti-jiang 

DOI:10.3969/j.issn.1674-8034.2013.01.005.


[Abstract] Objective: To study cerebral microstructure changes in patients with idiopathic epilepsy by magnetization transfer imaging technique.Materials and Methods: Magnetization transfer imaging (MTI) were performed in thirty-two patients with idiopathic epilepsy and thirty-two healthy volunteers. MTI data were analyzed using voxel-based analyses of whole brain in statistical parametric mapping software (SPM2). Two-sample t-test was used to compare with two groups. Correlation between MTR and the illness duration was analyzed. The differences of P<0.05 would be considered as statistical significance.Results: Compared with normal control group, MTR reduction areas were mainly located in bilateral middle frontal gyrus, anterior cerebellar lobe, right medial prefrontal, paracentral lobule, superior frontal gyrus and left inferior parietal lobule (P<0.05). Negatively correlation was found in the occipital lingual gyrus, fusiform gyrus and left posterior lobe of cerebellum between MTR and the ill ness duration.Conclusions: MTI can detect the potential neuropathological changes of idiopathic epilepsy, and provide a theoretical basis for pathophysiological mechanism in epilepsy.
[Keywords] Epilepsy；Magnetic resonance imaging；Magnetization transfer imaging

LIU Xin-feng Department of Radiology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China; Department of Radiology, Pepole's Hospital of Guizhou province, Guiyang 550002, China

CAO Yu-ping Department of Radiology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China

OU Xin-wei Department of Radiology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China

LIAO Da-wei Department of Radiology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China

ZHANG Guo-ming Department of Radiology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China

ZHU Ke-wen Department of Radiology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China

PENG Lan Department of Radiology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China

ZHANG Ti-jiang* Department of Radiology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China

*Correspondence to: Zhang TJ, E-mail: tijzhang@163.com

Conflicts of interest   None.

Received  2012-10-26
Accepted  2012-11-29
DOI: 10.3969/j.issn.1674-8034.2013.01.005
DOI:10.3969/j.issn.1674-8034.2013.01.005.

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