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Review
The application of diffusion-weighted magnetic resonance imaging in liver
CHEN Xin  LIANG Chang-hong  LIU Zai-yi 

DOI:10.3969/j.issn.1674-8034.2012.01.015.


[Abstract] Diffusion-weighted magnetic resonance imaging is one of the functional MR imaging techniques and is used for the diagnosis of cerebral early infarction. Recently, with the MR hardware and software development, the research on the applications of DWI in liver is increasingly reported and most of them are focused on the DWI technique improvement and the application in the diagnosis and treatment evaluation of liver diseases. New DWI techniques are developed to reduce motion artifact to improve the imaging quality. The clinical applications of DWI in liver disease include lesion detection, characterization and assessment of response to treatment strategies. In this review, we would summarize the state of the art of the DWI techniques and its clinical application in liver diseases.
[Keywords] Diffusion magnetic resonance imaging;Liver diseases

CHEN Xin Department of Raiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China; Graduate College, Southern Medical University, Guangzhou 510515, China

LIANG Chang-hong Department of Raiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China

LIU Zai-yi* Department of Raiology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China

*Correspondence to: Liu ZY, E-mail: zyliu@163.com

Conflicts of interest   None.

Received  2012-10-29
Accepted  2012-12-03
DOI: 10.3969/j.issn.1674-8034.2012.01.015
DOI:10.3969/j.issn.1674-8034.2012.01.015.

[1]
Schaefer PW, Grant PE, Gonzalez RG. Diffusion-weighted MR imaging of the brain. Radiology, 2000, 217(2): 331-345.
[2]
Taouli B, Koh DM. Diffusion-weighted MR imaging of the liver. Radiology, 2010, 254(1): 47-66.
[3]
Kwee TC, Takahara T, Niwa T, et al. Influence of cardiac motion on diffusion-weighted magnetic resonance imaging of the liver. MAGMA, 2009, 22(5): 319-325.
[4]
Kandpal H, Sharma R, Madhusudhan KS, et al. Respiratory-triggered versus breath-hold diffusion-weighted MRI of liver lesions: comparison of image quality and apparent diffusion coefficient values. AJR Am J Roentgenol, 2009, 192(4): 915-922.
[5]
Choi SA, Lee SS, Jung IH, et al. The effect of gadoxetic acid enhancement on lesion detection and characterisation using T (2) weighted imaging and diffusion weighted imaging of the liver. Br J Radiol, 2012, 85(1009): 29-36.
[6]
Kwee TC, Takahara T, Koh DM, et al.Comparison and reproducibility of ADC measurements in breathhold, respiratory triggered, and free-breathing diffusion-weighted MR imaging of the liver. J Magn Reson Imaging, 2008, 28(5): 1141-1148.
[7]
Nasu K, Kuroki Y, Sekiguchi R, et al. The effect of simultaneous use of respiratory triggering in diffusion-weighted imaging of the liver. Magn Reson Med Sci, 2006, 5(3): 129-136.
[8]
Parikh T, Drew SJ, Lee VS, et al. Focal liver lesion detection and characterization with diffusion-weighted MR imaging: comparison with standard breath-hold T2-weighted imaging. Radiology, 2008, 246(3): 812-822.
[9]
Holzapfel K, Bruegel M, Eiber M, et al. Characterization of small (</=10 mm) focal liver lesions: value of respiratory-triggered echo-planar diffusion-weighted MR imaging. Eur J Radiol, 2010, 76(1): 89-95.
[10]
Eatesam M, Noworolski SM, Tien PC, et al. Liver diffusivity in healthy volunteers and patients with chronic liver disease: comparison of breathhold and free-breathing techniques. J Magn Reson Imaging, 2012, 35(1): 103-109.
[11]
Kim SY, Lee SS, Byun JH, et al. Malignant hepatic tumors: short-term reproducibility of apparent diffusion coefficients with breath-hold and respiratory-triggered diffusion-weighted MR imaging. Radiology, 2010, 255(3): 815-823.
[12]
Liau J, Lee J, Schroeder ME, et al. Cardiac motion in diffusion-weighted MRI of the liver: artifact and a method of correction. J Magn Reson Imaging, 2012, 35(2): 318-327.
[13]
Yang DM, Jahng GH, Kim HC, et al. The detection and discrimination of malignant and benign focal hepatic lesions: T2 weighted vs diffusion-weighted MRI. Br J Radiol, 2011, 84(1000): 319-326.
[14]
Zech CJ, Herrmann KA, Dietrich O, et al.Black-blood diffusion-weighted EPI acquisition of the liver with parallel imaging: comparison with a standard T2-weighted sequence for detection of focal liver lesions. Invest Radiol, 2008, 43(4): 261-266.
[15]
Bruegel M, Gaa J, Waldt S, et al. Diagnosis of hepatic metastasis: comparison of respiration-triggered diffusion-weighted echo-planar MRI and five t2-weighted turbo spin-echo sequences. AJR Am J Roentgenol, 2008, 191(5): 1421-1429.
[16]
Wang H, Wang XY, Jiang XX, et al. Comparison of diffusion-weighted with T2-weighted Imaging for detection of small hepatocellular carcinoma in cirrhosis: preliminary quantitative study at 3-T. Acad Radiol, 2010, 17(2): 239-243.
[17]
Chung WS, Kim MJ, Chung YE, et al. Comparison of gadoxetic acid-enhanced dynamic imaging and diffusion-weighted imaging for the preoperative evaluation of colorectal liver metastases. J Magn Reson Imaging, 2011, 34(2): 345-353.
[18]
Hardie AD, Naik M, Hecht EM, et al. Diagnosis of liver metastases: value of diffusion-weighted MRI compared with gadolinium-enhanced MRI. Eur Radiol, 2010, 20(6): 1431-1441.
[19]
Kim YK, Kim CS, Han YM, et al. Detection of liver malignancy with gadoxetic acid-enhanced MRI: is addition of diffusion-weighted MRI beneficial? Clin Radiol, 2011, 66(6): 489-496.
[20]
Bruegel M, Holzapfel K, Gaa J, et al. Characterization of focal liver lesions by ADC measurements using a respiratory triggered diffusion-weighted single-shot echo-planar MR imaging technique. Eur Radiol, 2008, 18(3): 477-485.
[21]
Muhi A, Ichikawa T, Motosugi U, et al. High-b-value diffusion-weighted MR imaging of hepatocellular lesions: estimation of grade of malignancy of hepatocellular carcinoma. J Magn Reson Imaging, 2009, 30(5): 1005-1011.
[22]
Miller FH, Hammond N, Siddiqi AJ, et al. Utility of diffusion-weighted MRI in distinguishing benign and malignant hepatic lesions. J Magn Reson Imaging, 2010, 32(1): 138-147.
[23]
Gourtsoyianni S, Papanikolaou N, Yarmenitis S, et al. Respiratory gated diffusion-weighted imaging of the liver: value of apparent diffusion coefficient measurements in the differentiation between most commonly encountered benign and malignant focal liver lesions. Eur Radiol, 2008, 18(3): 486-492.
[24]
Taouli B, Vilgrain V, Dumont E, et al. Evaluation of liver diffusion isotropy and characterization of focal hepatic lesions with two single-shot echo-planar MR imaging sequences: prospective study in 66 patients. Radiology, 2003, 226(1): 71-78.
[25]
Szafer A, Zhong J, Anderson AW, et al. Diffusion-weighted imaging in tissues: theoretical models. NMR Biomed, 1995, 8(7-8): 289-296.
[26]
Wybranski C, Zeile M, Lowenthal D, et al. Value of diffusion weighted MR imaging as an early surrogate parameter for evaluation of tumor response to high-dose-rate brachytherapy of colorectal liver metastases. Radiat Oncol, 2011, 6(1): 43.
[27]
Koh DM, Scurr E, Collins D, et al. Predicting response of colorectal hepatic metastasis: value of pretreatment apparent diffusion coefficients.AJR Am J Roentgenol, 2007, 188(4): 1001-1008.
[28]
Yuan Z, Ye XD, Dong S, et al. Role of magnetic resonance diffusion-weighted imaging in evaluating response after chemoembolization of hepatocellular carcinoma. Eur J Radiol, 2010, 75(1): e9-e14.

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