Share：
Share this content in WeChat
X
[Chinese][PDF]80966
• Clinical Article •
Diffusion tensor imaging study of patients with metabolic syndrome
CHEN Wei  RONG Yu  YANG Zhong-xian  ZHANG You-qiao  YANG Jie-hua  ZHENG Xiao-hong  WU Ren-hua 

DOI:10.3969/j.issn.1674-8034.2013.02.001.


[Abstract] Objective: In order to understand whether there is subclinical damage of nerve fibre’s structure in the brain of metabolic syndrome (MS) with the course longer than 5 years, we used diffusion tensor imaging (DTI) to detect the FA values in the brain.Materials and Methods: 32 participants were categorized into two groups, metabolic syndrome group (15 participants) and control group (17 participants), ranging from 47 to 69 years old. We measured their body height, weight, blood pressure, blood glucose, blood lipid, scale about nerves function and examined their brain using magnetic resonance imaging (MRI) and magnetic resonance diffusion tensor imaging (DTI). Then the data were tested by statistical analysis.Results: (1) Compared with the control group, the FA values of posterior limb of internal capsule (PLIC) and corona radiate area (CRA) were lower and significant decline was found (P<0.01). The FA values of PLIC and CRA with three components of metabolic disorder in MS group were lower and significant decline was found (P<0.01). The FA values of CRA with two components of metabolic disorder in MS group were lower and significant decline was found (P<0.05). (2) Compared with the control group, the FA values of PLIC and CRA with hypertension, diabetes mellitus, hyperlipidemia, obesity in MS group were lower and significant decline was found (P<0.05). (3) The multiple regression results: the FA values were negatively associated with hyperlipidemia, hypertension and obesity (r=-0.127, -0.103, -0.012, P<0.05). The FA values of CRA were negatively associated with age (r=-0.04, P<0.05), and negatively associated with the course of hypertension (r=-0.013, P<0.05).Conclusions: During this study, we found that there were significant changes in nerve fibre’s structure in the brain of metabolic syndrome group with the course longer than 5 years. The severity of nerve fibre’s structure in the brain is related to the degree of metabolism dysfunction and the course of metabolism abnormality. Hypertension, hyperlipidemia and obesity were the independent risk factors for the damage of nerve fibre’s structure.
[Keywords] Metabolic syndrome x；Diffusion magnetic resonance imaging

CHEN Wei* Department of Neurology, the Second Affiliated Hospital, Medical College of Shantou University, Guangdong, Shantou 515041, China

RONG Yu Department of Neurology, the Second Affiliated Hospital, Medical College of Shantou University, Guangdong, Shantou 515041, China

YANG Zhong-xian Department of Medical Imaging, the Second Affiliated Hospital, Medical College of Shantou University, Guangdong, Shantou 515041, China

ZHANG You-qiao Department of Neurology, the Second Affiliated Hospital, Medical College of Shantou University, Guangdong, Shantou 515041, China

YANG Jie-hua Department of Neurology, the Second Affiliated Hospital, Medical College of Shantou University, Guangdong, Shantou 515041, China

ZHENG Xiao-hong Department of Neurology, the Second Affiliated Hospital, Medical College of Shantou University, Guangdong, Shantou 515041, China

WU Ren-hua Department of Medical Imaging, the Second Affiliated Hospital, Medical College of Shantou University, Guangdong, Shantou 515041, China

*Correspondence to: Chen W, chw7203@126.com

Conflicts of interest   None.

Received  2012-12-15
Accepted  2013-01-20
DOI: 10.3969/j.issn.1674-8034.2013.02.001
DOI:10.3969/j.issn.1674-8034.2013.02.001.

[1]
田勤，史大鹏，郭慧丽,等.糖尿病视神经病变磁共振扩散张量成像诊断价值探讨.磁共振成像, 2012, 3(1): 12-14.
[2]
王红，马景旭，贾文霄,等.弥散张量成像FA值和ADC值在颅内肿瘤病变中的应用.磁共振成像, 2012, 3(2): 136-140.
[3]
Briet M, Schiffrin EL. The role of aldosterone in the metabolic syndrome. Curr Hypertens Rep, 2011, 13(2): 163-172.
[4]
中华医学会糖尿病学分会代谢综合征研究协作组.中华医学会糖尿病学分会关于代谢综合征的建议.中华糖尿病杂志, 2004, 12(3): 156-161.
[5]
贺建华，吴兆苏，赵冬,等.高血压病患者的脑磁共振成像改变.中华老年心脑血管病杂志, 2003, 5(2): 99-102.
[6]
陈雯洁，俞茂华，黄延焱,等.老年代谢综合征与弥散张量成像研究.复旦学报医学版, 2009, 36(1): 41-45.
[7]
Park K, Yasuda N, Toyonaga S, et al. Significant association between leukoaraiosis and metabolic syndrome in healthy subjects. Neurology, 2007, 69(10): 974-978.
[8]
于慧玲，赵黎明，田慧.代谢综合征与脑白质病变关系研究.人民军医, 2010, 53(12): 922-923.
[9]
管锦群，张熙，蒋田仔,等.高血压相关脑白质损伤的磁共振弥散张量研究.中华保健医学杂志, 2011, 13(1): 11-14.
[10]
van der Meer RW, Lamb HJ, Smit JW, et al. MR imaging evaluation of cardiovascular risk in metabolic syndrome. Radiology, 2012, 264(1): 21-37.

PREV The application of diffusion -weighted magnetic resonance imaging in liver
NEXT Magnetic resonance spectroscopy study of patients with metabolic syndrome
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn