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• Clinical Article •
A quantitative susceptibility mapping of brain iron overload in spontaneous intracerebral hemorrhage: a quantitative 3 T MRI study
FAN Jing-zheng  LI Guan-wu  TIAN Ya-nan  ZHOU Lei  CHEN Yao  YUAN Jun  HUANG Ying-zhu  CHANG Shi-xin 

DOI:10.3969/j.issn.1674-8034.2013.02.004.


[Abstract] Objective: To evaluate the potential value of the brain iron overload deposition of globus pallidus (GP) in patients with spontaneous intracerebral hemorrhage (ICH) by quantitative susceptibility mapping (QSM).Materials and Methods: The data of 21 patients with ICH and 20 healthy controls(HC) who had MR multi-echo QSM and CT performed were retrospectively analysized. The magnetic susceptibility of GP was quantitative detected in all cases. The difference of magnetic susceptibility was analysized between ICH and HC with Mann-Whitney test. Correlation analysis was performed between the magnetic susceptibility of GP、T2SI and age with Pearson. Spearman correlation analysis was performed between the magnetic susceptibility of GP and onset time.Results: The difference of the magnetic susceptibility in GP was observed between ICH group and HC (Z=-4.147 P<0.05). The magnetic susceptibility of GP was negatively correlated with T2SI (r=-0.715) and positively correlated with time of onset (r=0.434)in ICH group. However, no relationships was detected between the magnetic susceptibility and age (P>0.05)in all cases.Conclusions: The iron overload of GP may be a predictor of the brain damage and neurodegenerative. The quantitative assessment of non-heme iron overload in GP by QSM may be one of the indicators refer in the ICH patients.
[Keywords] Intracerebral hemorrhage；QSM；Susceptibility；Iron quantitation

FAN Jing-zheng Department of Radiology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437 china

LI Guan-wu Department of Radiology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437 china

TIAN Ya-nan Department of Radiology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437 china

ZHOU Lei Department of Radiology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437 china

CHEN Yao Department of Radiology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437 china

YUAN Jun Department of Radiology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437 china

HUANG Ying-zhu Department of Radiology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437 china

CHANG Shi-xin* Department of Radiology, Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200437 china

*Correspondence to: Zeng WB, E-mail: wbzeng@hotmail.com

Conflicts of interest   None.

Received  2012-10-25
Accepted  2012-12-28
DOI: 10.3969/j.issn.1674-8034.2013.02.004
DOI:10.3969/j.issn.1674-8034.2013.02.004.

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