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• Original Article •
MRI study of traumatic penumbra of focal brain injury in cats
ZHANG Yao  CHEN Hong-yan  SHI Dong-li  LIU Ying  ZHANG Lei  JIN Zhen  MA Jun 

DOI:10.3969/j.issn.1674-8034.2013.02.010.


[Abstract] Objective: This study is to investigate the existence of traumatic penumbra around the focal brain contusion by using magnetic resonance imaging.Materials and Methods: Nine cats were randomly divided into traumatic group (n=5) and control group (n=4). Modified Feeney’s model was adopted to set up focal traumatic brain injury cat model in traumatic group. MR sequences were performed at 6 h and 24 h after injury. The extent of the brain lesion on different MR sequences was delineated and calculated. The data were analyzed by one-way analysis of variance, least significant difference and paired t-test for multiple comparisons. Histological examination was performed after the last MR examination.Results: In the traumatic group, the area of the abnormal signal intensity is larger on perfusion weighted images (PWI) than on structural fluid attenuated inversion recovery (FLAIR) images at both 6 h group (P<0.05) and 24 h group (P<0.05). And the area of the abnormal signal intensity on FLAIR is expanding from 6 h to 24 h after the injury (paired t-test, P<0.05). Ultrastructural observation revealed that cells in peri-contusion area showed degeneration change, disordered microcirculation and disrupted mitochondrion.Conclusions: Pathologically, the peri-contusion area might indicate the existence of penumbra tissue, which might be observed on MRI by showing the mismatch between FLAIR and PWI images.
[Keywords] Brain injury；Penumbra；Magnetic resonance imaging；Microscopy, electron；Animals, laboratory

ZHANG Yao Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China; Department of Radiology, Shijingshan Hospital, Beijing, 100043, China

CHEN Hong-yan Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China

SHI Dong-li Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China

LIU Ying Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China

ZHANG Lei Department of Magnetic Resonance, 306th Hospital of PLA, 100101, China

JIN Zhen Department of Magnetic Resonance, 306th Hospital of PLA, 100101, China

MA Jun* Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China

*Correspondence to: Ma J,E-mail: dr_ma@sina.com

Conflicts of interest   None.

Received  2013-02-07
Accepted  2013-02-20
DOI: 10.3969/j.issn.1674-8034.2013.02.010
DOI:10.3969/j.issn.1674-8034.2013.02.010.

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