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Clinical Article
The MRI features of the preterm and full-term neonatal hypoxic ischemic brain damage
TANG Yi  LIU Ying 

DOI:10.3969/j.issn.1674-8034.2013.03.005.


[Abstract] Objective: This study aims to study the neonatal hypoxic ischemic brain damage (HIBD) MRI features.Materials and Methods: 40 HIBD cases were collected. Premature neonates 20 cases and 20 cases full-term neonates, all of them were adept T1WI, T2WI, FLAIR, DWI and SWI multiple sequence scanning in postnatal 10 days. Image analysis and distinguish the major injury type of each HIBD case. The statistical software SPSS 13.0 was used to analysis the impact of gestational age and asphyxia degrees on the injury types.Results: The basal ganglia areas injury 15 cases (preterm neonate 8\full-term neonate 7) is seen in premature and full-term severe HIBD neonates. The pure periventricular white matter ischemic injury 9 cases (preterm neonate 7\full-term neonate 2) is seen in premature and full-term mild to moderate and severe HIBD neonates. The periventricular white matter hemorrhagic injury 5 cases (preterm neonate 5\full-term neonate 0) is most commonly seen in premature mild to moderate and severe HIBD neonates. The cortex and watershed white matter areas injury 7 cases (preterm neonate 0\full-term neonate 7) is seen in full-term mild to moderate HIBD neonates. 4 cases of diffuse brain injury (preterm neonate0\full-term neonate 4) is seen in full-term severe HIBD neonates. The corpus callosum injury 15 cases (preterm neonate 7\full-term neonate 8) is seen in premature and full-term mild to moderate and severe HIBD neonates.Brainstem, cerebellum and hippocampal damage sum to 7 cases (preterm neonate 3\full-term neonate 4) is seen in severe HIBD neonates.Conclusions: HIBD MR imaging has characteristic injury types differences that vary according to the neonates gestational ages and the degree of the severity of the asphyxia.
[Keywords] Infant, newborn;Hypoxic-Ischemic,brain;Magnetic resonance imaging;Infant, premature,diseases

TANG Yi Imaging Department of the Affiliated Provincial Hospital of Anhui Medical University, Hefei 230001, China

LIU Ying* Imaging Department of the Affiliated Provincial Hospital of Anhui Medical University, Hefei 230001, China

*Correspondence to: LIU Ying, E-mail: felice828@126.com

Conflicts of interest   None.

Received  2012-10-16
Accepted  2013-02-26
DOI: 10.3969/j.issn.1674-8034.2013.03.005
DOI:10.3969/j.issn.1674-8034.2013.03.005.

[1]
韩玉坤,杨于嘉,邵肖梅,等.新生儿缺血缺氧性脑病.北京:人民卫生出版社, 2010: 255-265.
[2]
de Vries LS, Groenendaal F. Patterns of neonatal hypoxic-ischemic brain injury. Neuoradiology, 2010, 52(6): 555-566.
[3]
Shroff MM, Soares-Fernandes JP, Whyte H, et al. MR imaging for diagnostic evaluation of encephalopathy in the newborn. Radiographics, 2010, 30(3): 763-780.
[4]
Rutherford M, Biarge MM, Allsop J, et al. MRI of perinatal brain injury. Pediatr Radiol, 2010, 40(6): 819-833.
[5]
冀旭,范国光.连续动脉自旋标记磁共振灌注成像对足月缺氧缺血性脑病患儿的初步研究.磁共振成像, 2011, 2(1): 19-23.
[6]
Logitharajah P, Rutherford MA, Cowan FM. Hypoxic ischaemic encephalopathy in the preterm infant: antecedent factors, brain imaging and outcome. Pediatr Res, 2009, 66(2): 222-229.
[7]
Liauw L, van der Grond J, vanden Berg-Huysmans AA, et al. Hypoxic-ischemic encephalopathy: diagnostic value of conventional MR imaging pulse sequences in term-born neonates. Radiology, 2008, 247(10): 204-212.
[8]
Barkovich AJ, Miller SP, Bartha A, et al. MR imaging MR spectroscopy, and Diffusion tensor imaging of sequential studies in neonates with encephalopathy. AJNR Am J Neuroradiol, 2006, 27(3): 533-547.
[9]
Volpe JJ. Brain injury in the premature infant: overview of clinical aspects, neuropathology, and pathogenesis. In: Volpe JJ. Neurology of the newborn. Philadelphia: Elsevier Inc, 2008: 279-347.
[10]
Steinman KJ, Gorno-Tempini ML, Glidden DV, et al. Neonatal watershed brain injury on magnetic resonance imaging correlates with verbal IQ at 4 years. Pediatrics, 2009, 123(3): 1025-1030.
[11]
Twomey E, Twomey A, Ryan S, et al. MR imaging of term infants with hypoxic-ischemic encephalopathy as a predictor of neurodevelopmental outcome and late MRI appearances. Pediatr Radiol, 2010, 40(9): 1526-1535.
[12]
Domi T, de Veber G, Shroff M, et al. Corticospinal tract pre-wallerian degeneration: a novel outcome predictor for pediatric stroke on acute MRI. Stroke, 2009, 40(3): 780-787.
[13]
Burns CM, Rutherford MA, Boardman JP, et al. Patterns of cerebral injury and neurodevelopmental outcomes after symptomatic neonatal hypoglycemia. Pediatrics, 2008, 122(1): 65-74.
[14]
Govaert P, Lequin M, Swarte R, et al. Changes in globus pallidus with (pre)term kernicterus. Pediatrics, 2003, 112(6): 1256-1263.
[15]
穆靓,杨健,鱼博浪.磁共振弥散加权及张量技术在新生儿缺血缺氧性脑病中的应用.磁共振成像, 2010, 1(1): 60-64.

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