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• Clinical Article •
Glioblastoma multi-mode MRI manifestations and pathological histology foundation
WU Yu-qiang  LIN Qi  LAN Yu-hua  TAN Ping-tai  CHEN Jin-yin 

DOI:10.3969/j.issn.1674-8034.2013.03.007.


[Abstract] Objective: To investigate the multi mode MRI features of glioblastomas and its basis of histopathology.Materials and Methods: The collection of 22 cases confirmed by operation and pathology in patients with glioblastoma MRI data. Male 11 cases, female 11 cases.Results: (1) Position: frontal lobe 7 cases, temporal lobe 4 cases, frontotemporal 4 cases, temporal and occipital 4 cases, frontoparietal 1 cases, Occipital lobe 1 case, cerebellum in 1 cases. (2) Number: single lesion in 19 cases, multiple focal lesions in 3 cases. (3) The conventional MRI performance: ①Forms are irregular, mass effect in 20 cases. ② Intralesional obvious necrosis in 19 cases. ③ Hemorrhage: Obviously in 5 cases, a small amount of 3 cases. ④ Edge blur in 17 cases. ⑤ Peripheral edema 4 cases of mild, 6 cases of moderate, 6 cases of severe. (4) Enhance: Expression of heterogeneous enhancement, wall thickness unevenness or petal shaped in 17 cases. (5) Apparent diffusion coefficient (b=1000s/mm2), the tumor parenchyma (0.850-1.278)×10-3mm2/s. (6) Susceptibility-weighted imaging: intratumoral susceptibility signals (ITSS) the I grade in 2 cases, II grade in 7 cases and III grade in 13 cases. (7) 1H-MRS; The NAA wave was significantly reduced in the tumor parenchyma, Cr crest drop, increased Cho wave, Cho/NAA 6.18±1.97, Cho/Cr 4.65±2.21,12 cases of apparent wave Lip. Peripheral edema increased Cho wave. Histopathology: pleomorphic astrocytoma, cell dysplasia was evident, mitotic activity, pronounced in invasive growth, obvious necrosis and hyperplasia is the most striking feature. Immunohistochemistry: Glial fibrillary acidic protein positive, Vimentin positive, high expression of Ki-67.Conclusions: multi mode MRI can display the glioblastoma tumor internal structure, peritumoral fiber beam changes, cell density, metabolite concentrations and other information, the tumor diagnosis and differential diagnosis of it has important clinical value.
[Keywords] Glioblastoma；Magnetic resonance imaging；Pathology

WU Yu-qiang Department of Radiology, the First Hospital of Longyan, Hospital of Fujian Medical University, Longyan 364000, China

LIN Qi* Department of Radiology, the First Hospital of Longyan, Hospital of Fujian Medical University, Longyan 364000, China

LAN Yu-hua Department of Radiology, the First Hospital of Longyan, Hospital of Fujian Medical University, Longyan 364000, China

TAN Ping-tai Department of Radiology, the First Hospital of Longyan, Hospital of Fujian Medical University, Longyan 364000, China

CHEN Jin-yin Department of Radiology, the First Hospital of Longyan, Hospital of Fujian Medical University, Longyan 364000, China

*Correspondence to: Lin Q, E-mail: 2624403530@qq.com

Conflicts of interest   None.

Received  2012-10-26
Accepted  2012-12-15
DOI: 10.3969/j.issn.1674-8034.2013.03.007
DOI:10.3969/j.issn.1674-8034.2013.03.007.

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