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• Clinical Article •
Assessment of idiopathic growth hormone deficiency in the morphologically normal pituitary using dynamic contrast-enhanced MR imaging
XIE Ming-wei  CHEN Yue-yao  WU Zhuo  SHEN Jun  LIANG Bi-ling 

DOI:10.3969/j.issn.1674-8034.2013.04.003.


[Abstract] Objectives: To investigate the dynamic contrast-enhanced MR imaging features of pituitary in the idiopathic growth hormone deficiency (IGHD) patients with morphologically normal pituitary gland.Materials and Methods: 21 IGHD patients with normal pituitary morphology and 17 healthy age-matched controls were included for analysis. Multisection coronal dynamic contrast-enhanced MR imaging of pituitary was performed. Time to peek (TTP) and maximum enhancement ratio (Rmax) were derived from the signal intensity-time curve of anterior pituitary and compared between IGHD patients and normal controls using the independent t test. Pearson correlation analysis was used to determine the correlation between the TTP or Rmax and the growth hormone deficiency levels.Results: The IGHD patients had a prolonged TTP than normal controls (P<0.05), but the Rmax was not significantly different from that in normal controls (P>0.05). The levels of serum growth hormone were negatively correlated with the TTP (P<0.05), but not with Rmax (P>0.05).Conclusions: A delayed TTP on dynamic contrast-enhanced MR imaging could be indicative of IGHD in symptomatic patients with a morphologically normal pituitary. The degree of growth hormone deficiency was associated with regional perfusion delay.
[Keywords] Dwarfism, pituitary；Pituitary gland, anterior；Magnetic resonance imaging

XIE Ming-wei Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

CHEN Yue-yao Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

WU Zhuo Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

SHEN Jun Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

LIANG Bi-ling Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China

Conflicts of interest   None.

Received  2013-04-16
Accepted  2013-05-20
DOI: 10.3969/j.issn.1674-8034.2013.04.003
DOI:10.3969/j.issn.1674-8034.2013.04.003.

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