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• Clinical Article •
Comparative study of DWI and Fi-broscan in diagnosis of liver fibrosis
HUANG Yong-yue  JIN Jun  TANG Xiao-li  WANG Xiao-yi 

DOI:10.3969/j.issn.1674-8034.2013.04.005.


[Abstract] Objective: Comparative study the diagnostic value of diffusion weighted imaging (DWI) and Fi-broscan(FS)in diagnosis of liver fibrosis.Materials and Methods: Thirty-five hepatic fibrosis patients and 21 normal controls received DWI (b1=0s/mm2, b2=600s/mm2), ADC value of different fibrosis stages was measured, while 33 patients and all 21 normal controls received FS. The elastic stiffness value (stiffness) achieved in 10 successful FibroScan examinations was taken as Fi-brosan index. Analysis of variances was performed to compare the difference among the groups in both examinations. ROC curve was used to analyze the sensitivity and specificity of DWI and FS.Results: The value of stiffness was gradually increased from the liver fibrosis stage S0 to S4, while the mean ADC value decreased as the severity of liver fibrosis increased(P<0.01). Between control group and S1, S2, S3, S4 group and among group S2, group S3, group S4 was significant. Sensitivity of DWI and FS was 79.40% and 86.33%. Specificity of DWI and FS was 83.60% and 76.91%.Conclusions: Sensitivity of FS is higher than DWI, while specificity of DWI is superior to FS. Therefore, the application both DWI and FS is the best examinational method for early diagnosis and de-grading of liver fibrosis.
[Keywords] Liver diseases；Fibrosis；Diffusion magnetic resonance imaging；Ultrasonography；Contrastive study

HUANG Yong-yue Department of Radiology, Shenzhen Shekou People’s Hospital of Guangdong Province, Shenzhen 518067, China

JIN Jun Department of Radiology, Shenzhen Shekou People’s Hospital of Guangdong Province, Shenzhen 518067, China

TANG Xiao-li* Department of Radiology, Shenzhen Shekou People’s Hospital of Guangdong Province, Shenzhen 518067, China

WANG Xiao-yi Department of Radiology, Xiangya Hospital, Central South University, Changsha 410008, China

*Correspondence to: Tang XL, E-mail: 303175614@qq.com

Conflicts of interest   None.

Received  2013-05-26
Accepted  2013-06-18
DOI: 10.3969/j.issn.1674-8034.2013.04.005
DOI:10.3969/j.issn.1674-8034.2013.04.005.

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