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• Clinical Article •
The comparison between monoexponential and biexponential function of multi-b DWI in evaluation of clear cell renal cell carcinoma
DING Jiu-le  XING Wei  CHEN Jie  YU Sheng-nan  SUN Jun  XING Shi-jun 

DOI:10.3969/j.issn.1674-8034.2013.04.006.


[Abstract] Objective: To probe the value of monoexponential and biexponential function used in multi-b DWI on the grading of the CCRCC before the surgery.Materials and Methods: The imaging and pathological data sets of 32 cases with CCRCC were assessed retrospectively. There were low grade (Group 1) and high grade (Group 2) group confirmed by Fuhrman Grading. Based on the conventional MR images, the region of interesting was plotted by a radiologist, and ranges from 0.30 cm2 to 0.45 cm2 in tumorous parenchyma on multi-b DWI. The signal intensity of ROI on DWI each b value were recorded. The ADC value is calculated in monoexponential function, and F, Dfast and Dslow were calculated in biexponential function. The differences of each parameter between two groups were compared with nonparametric test. The receiver operating characteristic curve (ROC) was performed to evaluate diagnosibility during four parameters. There is a significant difference when the P<0.05.Results: 20 cases of low grade CCRCC and 12 cases of high grade were confirmed by the pathological test. There is not a significant difference (U=50.0, P=0.71) for ADC between two groups. Compared with Group 1, the F decreased in Group 2 (U=18.0, P=0.01), but Dfast and Dslow increased in Group 2 (U=15.0, P=0.01. U=20.0, P=0.02 respectively). F, Dfast and Dslow have the similar sensitivity and specificity in differential diagnosis between two groups (P=0.61, 0.77 and 0.44 respectively).Conclusions: Compared with the monoexponential function of multi-b DWI, the biexponential function is more suitable for grading of CCRCC preoperatively.
[Keywords] Adenocarcinoma, clear cell；Kidney neoplasms；Magnetic resonance imaging, diffusion

DING Jiu-le Department of Radiology, the First Hospital of Changzhou, Changzhou 213003, China

XING Wei* Department of Radiology, the First Hospital of Changzhou, Changzhou 213003, China

CHEN Jie Department of Radiology, the First Hospital of Changzhou, Changzhou 213003, China

YU Sheng-nan Department of Radiology, the First Hospital of Changzhou, Changzhou 213003, China

SUN Jun Department of Radiology, the First Hospital of Changzhou, Changzhou 213003, China

XING Shi-jun Department of Radiology, the First Hospital of Changzhou, Changzhou 213003, China

*Correspondence to: Xing W, E-mail: suzhxingwei@126.com

Conflicts of interest   None.

Received  2013-04-16
Accepted  2013-05-26
DOI: 10.3969/j.issn.1674-8034.2013.04.006
DOI:10.3969/j.issn.1674-8034.2013.04.006.

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