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• Original Article •
Comparison of perfusion imaging and microvessel density in rabbit models of hepatic VX2 tumors after high intensity focused ultrasound
CHEN Liang  WEI Xin-hua  XU Hong-gang  LIU Wei-feng  CHEN Li-peng  LIU Wen-feng  JIANG Xin-qing 

DOI:10.3969/j.issn.1674-8034.2013.04.009.


[Abstract] Objective: Compare perfusion-weighted imaging (PWI) characteristics and parameters changes with before and after high intensity focused ultrasound (HIFU), supposed to discuss the correlation of Maximal signal reduction slope (SRSmax) and microvessel density (MVD).Materials and Methods: Forty rabbit models of hepatic VX2 tumors were implated successfully, two weeks later, after routine scans were performed on 1.5 T MR scanner, using EPI-SE series, 40 New Zealand white rabbits with VX2 carcinoma were divided randomly into treatment group 20, control group 20, HIFU with treatment group. Perfusion-weighted imaging and enhanced scan were performed 14 d before and after HIFU with both groups. Select the region of interest (ROI) of the central of tumor, surrounding of tumor and paratumor parenchyma. SRSmax of the signal intensity versus time curves were created as quantitative variable. Analyze the SRSmax change degrees and regularities of different ROI. specimens of MVD were examined and compared with PWI.Results: Forty-eight lesions were detected in 40 rabbit models, and 36 lesions in 33 rabbit models were statistical analysis finally. Tumor showed heterogeneous were mixed with high signal, normal signal and low signal, the degrees and intensity of blood perfusion in different ROI were different. After HIFU, the SRSmax value of central and surrounding of tumor were statistically decreased than that before HIFU (P<0.05). In control group, the SRSmax value of central of tumor with second were statistically decreased than the first (P<0.05). The SRSmax value of surrounding of tumor in HIFU group were statistically decreased than that of control group (P<0.05). The SRSmax and MVD correlation analysis showed that they were positively correlated with surrounding of tumor in HIFU group (r=0.78, P=0.01).Conclusions: The degrees of blood perfusion of different ROI were consistented with the results of MVD. PWI on VX2 carcinomas are matched with the levels and scopes of necrosis, PWI can be used in evaluating the liver tumor angiogenesis and angioruin with the treatment of HIFU.
[Keywords] Carcinoma；hepatocellular；Ultrasonic therapy；Magnetic resonance image；Animals, laboratory

CHEN Liang Department of Radiology, Guangzhou First People's Hospital, Guangzhou 510180, China

WEI Xin-hua Department of Radiology, Guangzhou First People's Hospital, Guangzhou 510180, China

XU Hong-gang Department of Radiology, Guangzhou First People's Hospital, Guangzhou 510180, China

LIU Wei-feng Department of Radiology, Guangzhou First People's Hospital, Guangzhou 510180, China

CHEN Li-peng Department of Radiology, Guangzhou First People's Hospital, Guangzhou 510180, China

LIU Wen-feng Department of Radiology, Guangzhou First People's Hospital, Guangzhou 510180, China

JIANG Xin-qing* Department of Radiology, Guangzhou First People's Hospital, Guangzhou 510180, China

*Correspondence to: Jiang XQ, E-mail: jxqw@163.com

Conflicts of interest   None.

Received  2013-05-02
Accepted  2013-06-10
DOI: 10.3969/j.issn.1674-8034.2013.04.009
DOI:10.3969/j.issn.1674-8034.2013.04.009.

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