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• Original Article •
Effect of alcohol on diffuse axonal injury in rats brainstem: DTI study
ZHANG Hai-du  KONG Ling-mei  CHEN Ruo-wei  LIU Hui-ming  ZHENG Wen-bin 

DOI:10.3969/j.issn.1674-8034.2013.05.007.


[Abstract] Objective: To assess the effects of alcohol on traumatic brain injury (TBI) by using diffusion tensor imaging (DTI) in rat brainstems following acute alcohol intoxication with diffuse axonal injury (DAI).Materials and Methods: 85 male rats, divided into control group (group N), acute alcohol poisoning group (group A), DAI Group (group T) and ethanol-plus-DAI group (group AT). The control group and the experimental group (made into animal model after 1 h, 3 h, 6 h, 12 h, 24 h) were examined by MRI, and the brainstem pathology.Results: After acute alcoholism with DAI, ADC values of the brainstem first decreased within 6 h after injury and then elevated. FA values began decline by 1 h, reaching a minimum at 24 h after trauma. FA values were lower in the ethanol-plus-DAI group (group AT) compared to the DAI group (group T) at 3 h and 6 h. The ADC value of the ethanol-plus-DAI group (group AT) is lower than the DAI group (group T) in 12 h, but it is higher after 24 h.Conclusions: Acute ethanol consumption affects severity after DAI by accelerating brain edema and axonal injury. DTI can sensitively to detect acute alcohol intoxication with TBI in brainstem edema and axonal, while the routin MRI cannot found.
[Keywords] Diffuse axonal injury；Alcoholism；Magnetic resonance imaging

ZHANG Hai-du Department of Radiology, the Second Affiliated of Medical College of Shantou University, Shantou 515041, China

KONG Ling-mei Department of Radiology, the Second Affiliated of Medical College of Shantou University, Shantou 515041, China

CHEN Ruo-wei Department of Radiology, the Second Affiliated of Medical College of Shantou University, Shantou 515041, China

LIU Hui-ming Department of Radiology, the Second Affiliated of Medical College of Shantou University, Shantou 515041, China

ZHENG Wen-bin Department of Radiology, the Second Affiliated of Medical College of Shantou University, Shantou 515041, China

Conflicts of interest   None.

Received  2013-01-29
Accepted  2013-06-20
DOI: 10.3969/j.issn.1674-8034.2013.05.007
DOI:10.3969/j.issn.1674-8034.2013.05.007.

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