Share：
Share this content in WeChat
X
[Chinese][PDF]70970
• Original Article •
Effect of alcohol on diffuse axonal injury in rats brainstem: DTI study
ZHANG Hai-du  KONG Ling-mei  CHEN Ruo-wei  LIU Hui-ming  ZHENG Wen-bin 

DOI:10.3969/j.issn.1674-8034.2013.05.007.


[Abstract] Objective: To assess the effects of alcohol on traumatic brain injury (TBI) by using diffusion tensor imaging (DTI) in rat brainstems following acute alcohol intoxication with diffuse axonal injury (DAI).Materials and Methods: 85 male rats, divided into control group (group N), acute alcohol poisoning group (group A), DAI Group (group T) and ethanol-plus-DAI group (group AT). The control group and the experimental group (made into animal model after 1 h, 3 h, 6 h, 12 h, 24 h) were examined by MRI, and the brainstem pathology.Results: After acute alcoholism with DAI, ADC values of the brainstem first decreased within 6 h after injury and then elevated. FA values began decline by 1 h, reaching a minimum at 24 h after trauma. FA values were lower in the ethanol-plus-DAI group (group AT) compared to the DAI group (group T) at 3 h and 6 h. The ADC value of the ethanol-plus-DAI group (group AT) is lower than the DAI group (group T) in 12 h, but it is higher after 24 h.Conclusions: Acute ethanol consumption affects severity after DAI by accelerating brain edema and axonal injury. DTI can sensitively to detect acute alcohol intoxication with TBI in brainstem edema and axonal, while the routin MRI cannot found.
[Keywords] Diffuse axonal injury；Alcoholism；Magnetic resonance imaging

ZHANG Hai-du Department of Radiology, the Second Affiliated of Medical College of Shantou University, Shantou 515041, China

KONG Ling-mei Department of Radiology, the Second Affiliated of Medical College of Shantou University, Shantou 515041, China

CHEN Ruo-wei Department of Radiology, the Second Affiliated of Medical College of Shantou University, Shantou 515041, China

LIU Hui-ming Department of Radiology, the Second Affiliated of Medical College of Shantou University, Shantou 515041, China

ZHENG Wen-bin Department of Radiology, the Second Affiliated of Medical College of Shantou University, Shantou 515041, China

Conflicts of interest   None.

Received  2013-01-29
Accepted  2013-06-20
DOI: 10.3969/j.issn.1674-8034.2013.05.007
DOI:10.3969/j.issn.1674-8034.2013.05.007.

[1]
Wang H, Yu X, Xu G, et al. Alcoholism and traumatic subarachnoid hemorrhage: an experimental study on vascular morphology and biomechanics. J Trauma. 2011, 70(1): E6-12.
[2]
Marmarou A, Foda MA, van den Brink W, et al. A new model of diffuse brain injury in rats: Part I. Pathophysiology and biomechanics. J Neurosurg, 1994, 80 (2): 291-300.
[3]
Sher L. Alcohol and suicide: neurobiological and clinical aspects. Scientific World Journal, 2006, 6 (21): 700-706.
[4]
Savola O, Niemela O, Hillbom M. Alcohol intake and the pattern of trauma in young adults and working aged people admitted after trauma. Alcohol Alcohol, 2005, 40(4): 269-273.
[5]
Golan JD, Marcoux J, Golan E, et al. Traumatic brain injury in intoxicated patients. J Trauma, 2007, 63 (2): 365-369.
[6]
Rehm J, Mathers C, Popova S, et al. Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet, 2009, 273(9682): 2223-2233.
[7]
Gentry LR, Godersky JC, Thompson B. MR imaging of head trauma: review of the distribution and radiopathologic features of traumatic lesions. AJR Am J Roentgenol, 1988, 150(3): 663-672.
[8]
张海都，沈志威，孔令梅，等．枕叶皮质磁共振频谱在脑震荡的应用价值．磁共振成像, 2013, 4(2): 105-107.
[9]
Wakana S, Jiang H, Nagae-Poet LM, et al. Fiber tract-based atlas of human white matter anatomy. Radiology, 2004, 230(1): 77-87.
[10]
Cernak I, Vink R, Zapple DN, et al. The pathobiology of moderate diffuse traumatic brain injury as identified using a new experimental model of injury in rats. Neurobiol Dis, 2004, 17(1): 29-43.
[11]
徐永康，张志强，冯祖荫，等．急性酒精中毒对兔脑外伤后的影响.河南医科大学学报, 2001, 36(1): 51-53.

PREV The imaging features of synovial osteochondromatosis
NEXT Cardiac Dot Engine: makes cardiac MR scanning much easier
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn