Share：
Share this content in WeChat
X
[Chinese][PDF]87367
• Review •
The research progress of diffusion tensor imaging for early diagnosis of Alzheimer disease
ZHANG Chao  MU Xue-tao  WANG Hong 

DOI:10.3969/j.issn.1674-8034.2013.05.014.


[Abstract] Alzheimer disease (AD) is a chronic degenerative disease of central nervous system, with high incidence, diagnosed late, poor prognosis, which resulting in heavy burden of the family and the society. Magnetic resonance diffusion tensor imaging (DTI) is the only non-invasive method of displaying living brain white matter fiber currently. Studies have shown that DTI has a certain value for the diagnosis of Amnesia-mild cognitive impairment (aMCI) and AD, finding that the FA values decreased in the corpus callosum, the fornix and other areas in the brain of AD, which may providing some help for the early diagnosis of AD and the detection of pathological developments.
[Keywords] Alzheimer disease；Magnetic resonance imaging

ZHANG Chao Graduate School of Xuzhou Medical College, Xuzhou 221004, China; Department of MRI, the General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China

MU Xue-tao Department of MRI, the General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China

WANG Hong * Department of MRI, the General Hospital of Chinese People’s Armed Police Forces, Beijing 100039, China

*Correspondence to: Wang H, E-mail: wanghongmri@sina.com

Conflicts of interest   None.

Received  2013-07-18
Accepted  2013-08-16
DOI: 10.3969/j.issn.1674-8034.2013.05.014
DOI:10.3969/j.issn.1674-8034.2013.05.014.

[1]
Thies W, Bleiler L. Alzheimer's Association. 2013 Alzheimer's disease facts and figures. Alzheimers Dement, 2013, 9(2): 208-245.
[2]
齐志刚，李坤成．阿尔茨海默病的神经影像学诊断进展．国际医学放射学杂志, 2008, 14(8): 483-485.
[3]
Jones, DK, Leemans A. Diffusion tensor imaging. Methods Mol Biol, 2011, 711: 127-144.
[4]
Yap QJ, Teh I, Fusar-Poli P, et al. Tracking cerebral white matter changes across the lifespan: insights from diffusion tensor imaging studies. J Neural Transm, 2013, 18. [ DOI: ]
[5]
侯欣，鱼博浪，杨健．磁共振扩散张量成像在新生儿脑发育的应用及展望．磁共振成像, 2012, 3(1): 74-78.
[6]
Serra L, Cercignani M, Lenzi D, et al. Grey and white matter changes at different stages of Alzheimer’s disease. J Alzheimers Dis, 2010, 19(1): 147-159.
[7]
Di Paola M, Di Iulio F, Cherubini A, et al. When, where, and how the corpus callosum changes in MCI and AD: a multimodal MRI study. Neurology, 2010,74(14): 1136-1142.
[8]
Agosta F, Pievani M, Sala S, et al. White matter damage in Alzheimer disease and its relationship to gray matter atrophy. Radiology, 2011, 258(3): 853-863.
[9]
Kavcic V, Ni H, Zhu T, et al. White matter integrity linked to functional impairments in aging and early Alzheimer’s disease. Alzheimers Dement, 2008, 4(6): 381-389.
[10]
Xekardaki A, Giannakopoulos P, Haller S. White matter changes in bipolar disorder, Alzheimer Disease, and mild cognitive impairment: new insights from DTI. J Aging Research, 2011, 2011:1-10.
[11]
Bosch B, Arenaza-Urquijo EM, Rami L, et al. Multiple DTI index analysis in normal aging, amnestic MCI and AD. Relationship with neuropsychological performance. Neurobiol Aging, 2012, 33(1): 61-74.
[12]
Delano-Wood L, Stricker NH, Sorg SF, et al. Posterior cingulum white matter disruption and its associations with verbal memory and stroke risk in mild cognitive impairment. J Alzheimers Dis, 2012, 29(3): 589-603.
[13]
Jack CR Jr. Alzheimer disease: new concepts on its neurobiology and the clinical role imaging will play. Radiology, 2012, 263(2): 344-361.
[14]
Douaud G, Jbabdi S, Behrens TE, et al. DTI measures in crossing-fibre areas: increased diffusion anisotropy reveals early white matter alteration in MCI and mild Alzheimer’s disease. Neuroimage, 2011, 55(3): 880-890.
[15]
Zimny A, Szewczyk P, Trypka E, et al. Multimodal imaging in diagnosis of Alzheimer's disease and amnestic mild cognitive impairment: value of magnetic resonance spectroscopy, perfusion, and diffusion tensor imaging of the posterior cingulate region. J Alzheimers Dis, 2011, 27(3): 591-601.
[16]
Acosta-Cabronero J, Alley S, Williams GB, et al. Diffusion tensor metrics as biomarkers in Alzheimer's disease. PLoS One, 2012, 7(11): e49072.
[17]
Jahng GH, Xu S, Weiner MW, et al. DTI studies in patients with Alzheimer's disease, mild cognitive impairment, or normal cognition with evaluation of the intrinsic background gradients. Neuroradiology, 2011, 53(10): 749-762.
[18]
Ringman JM, O'Neill J, Geschwind D, et al. Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations. Brain, 2007, 130(7): 1767-1776.
[19]
Mielke MM, Kozauer NA, Chan KC, et al. Regionally-specific diffusion tensor imaging in mild cognitive impairment and Alzheimer’s disease. Neuroimage, 2009, 46(1): 47-55.
[20]
Huang H, Fan X, Weiner M, et al. Distinctive disruption patterns of white matter tracts in Alzheimer' s disease with full diffusion tensor characterization. Neurobiol Aging, 2012, 33(9): 2029-2045.
[21]
Donix M, Small GW, Bookheimer SY. Family history and APOE-4 genetic risk in Alzheimer's disease. Neuropsychol Rev, 2012, 22(3): 298-309.
[22]
Persson J, Lind J, Larsson A, et al. Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD? Neurology, 2006, 66(7): 1029-1033.
[23]
Bendlin BB, Ries ML, Canu E, et al. White matter is altered with parental family history of Alzheimer' s disease. Alzheimers Dement, 2010, 6(5): 394-403.
[24]
Winkler AM, Kochunov P, Blangero J, et al. Cortical thickness or grey matter volume? The importance of selecting the phenotype for imaging genetics studies. Neuroimage, 2010, 53(3): 1135-1146.
[25]
Reijmer YD, Leemans A, Heringa SM, et al. Improved sensitivity to cerebral white matter abnormalities in Alzheimer's disease with spherical deconvolution based tractography, PLoS One, 2012, 7(8): e44074.
[26]
李蓉，冯远静，邵开来．磁共振扩散高阶张量成像的脑白质纤维微结构模型及特征提取算法．中国生物医学工程学报, 2012, 31(3): 365-373.
[27]
Schmahmann JD, Pandya DN, Wang R, et al. Association fibre pathways of the brain parallel observations from diffusion spectrum imaging and autoradiography. Brain, 2007, 30(3): 630-653.
[28]
Lemkaddem A, Daducci A, Vulliemoz S, et al. A multi-center study intrascan and interscan variability of diffusion spectrum imaging. Neuroimage, 2012, 62(1): 87-94.

PREV MR imaging of the small bowel
NEXT Study of proton magnetic resonance spectroscopy in the aging process of normal brain
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn