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• Clinical Article •
The application value of whole body diffusion-weighted imaging in tumor lesions
GONG Jia-ying  ZHOU Zhi-yang  Deng Yan-hong  Kang Liang  CAO Wu-teng  LIAN Yan-bang  QIU Jian-ping  XIONG Fei  LI Wen-ru  LI Wen-li 

DOI:10.3969/j.issn.1674-8034.2013.06.005.


[Abstract] Objective: To investigate the clinical value of whole body diffusion-weighted imaging (WB-DWI) in discovery of malignant primary tumor and metastasis, assessment of tumor response to neoadjuvant therapy and postoperative follow-up.Materials and Methods: Fiber magnetic resonance scanner(GE Optimal 360 1.5 T, US) and short T1 inversion recovery echo-planar imaging diffusion weighted sequence (STIR-EPI-DWI) and body coil were used to obtain the WB-DWI for 7 volunteers and 70 diagnosed or suspected cancer patients. Meanwhile, all axial DWI and corresponding ADC figure with the same layer were collected. Then, the WB-DWI images were reconstructed using the three-dimensional maximum intensity projection(MIP) and inverted-gray-scale with AW 4.5 Functool DWI post processing software and images similar to PET images can be achieved. All WB-DWI images were compared with conventional MRI scanning.Results: High quality WB-DWI images were obtained for 7 volunteers and 70 patients. The primary tumor and metastatic lesions showed high signal on DWI images and low signal on ADC figures, and malignant lesions were not found in volunteers. Twelve cases in 30 patients who intended to assess distant metastases before therapy were detected metastases. Eleven cases in 70 patients who planned to evaluate tumor and metastases response to neoadjuvant therapy, within which 6 cases reduced in size, 1 case even achieved clinical remission, while 3 cases increased and 2 cases had no change. Twenty-eight cases conducted follow-up after comprehensive treatment, 16 cases without local recurrence and metastases, 5 with local recurrence, and 7 were found metastases. One patient with massive ascites took an examination and found abnormal high signal between right thigh muscle groups, confirmed by pathology hemangioma.Conclusions: WB-DWI can provide acceptable earlier and comparable efficacy guiding significance for tumor diagnosing, staging, and prognosing, therapeutic evaluation, which is more sensitive in detecting primary lesion and metastases. Compared with PET-CT, there is no radiation, without injection of contrast agent, and WB-DWI is more convenient and economic, so it is more suitable for cancer patients to evaluate response to neoadjuvant therapy and take long-term follow-up after operation and tumor screening of healthy crowd.
[Keywords] Diffusion magnetic resonance imaging；Neoplasm metastasis

GONG Jia-ying Department of Radiology, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510655, China

ZHOU Zhi-yang * Department of Radiology, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510655, China

Deng Yan-hong Department of Medical Ooncology, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510630, China

Kang Liang Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510630, China

CAO Wu-teng Department of Radiology, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510655, China

LIAN Yan-bang Department of Radiology, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510655, China

QIU Jian-ping Department of Radiology, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510655, China

XIONG Fei Department of Radiology, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510655, China

LI Wen-ru Department of Radiology, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510655, China

LI Wen-li Department of Radiology, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510655, China

*Correspondence to: Zhou ZY, Email: zhouzyang@hotmail.com

Conflicts of interest   None.

Received  2013-08-20
Accepted  2013-10-08
DOI: 10.3969/j.issn.1674-8034.2013.06.005
DOI:10.3969/j.issn.1674-8034.2013.06.005.

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