Share：
Share this content in WeChat
X
[Chinese][PDF]631104
• Clinical Article •
The application value of whole body diffusion-weighted imaging in tumor lesions
GONG Jia-ying  ZHOU Zhi-yang  Deng Yan-hong  Kang Liang  CAO Wu-teng  LIAN Yan-bang  QIU Jian-ping  XIONG Fei  LI Wen-ru  LI Wen-li 

DOI:10.3969/j.issn.1674-8034.2013.06.005.


[Abstract] Objective: To investigate the clinical value of whole body diffusion-weighted imaging (WB-DWI) in discovery of malignant primary tumor and metastasis, assessment of tumor response to neoadjuvant therapy and postoperative follow-up.Materials and Methods: Fiber magnetic resonance scanner(GE Optimal 360 1.5 T, US) and short T1 inversion recovery echo-planar imaging diffusion weighted sequence (STIR-EPI-DWI) and body coil were used to obtain the WB-DWI for 7 volunteers and 70 diagnosed or suspected cancer patients. Meanwhile, all axial DWI and corresponding ADC figure with the same layer were collected. Then, the WB-DWI images were reconstructed using the three-dimensional maximum intensity projection(MIP) and inverted-gray-scale with AW 4.5 Functool DWI post processing software and images similar to PET images can be achieved. All WB-DWI images were compared with conventional MRI scanning.Results: High quality WB-DWI images were obtained for 7 volunteers and 70 patients. The primary tumor and metastatic lesions showed high signal on DWI images and low signal on ADC figures, and malignant lesions were not found in volunteers. Twelve cases in 30 patients who intended to assess distant metastases before therapy were detected metastases. Eleven cases in 70 patients who planned to evaluate tumor and metastases response to neoadjuvant therapy, within which 6 cases reduced in size, 1 case even achieved clinical remission, while 3 cases increased and 2 cases had no change. Twenty-eight cases conducted follow-up after comprehensive treatment, 16 cases without local recurrence and metastases, 5 with local recurrence, and 7 were found metastases. One patient with massive ascites took an examination and found abnormal high signal between right thigh muscle groups, confirmed by pathology hemangioma.Conclusions: WB-DWI can provide acceptable earlier and comparable efficacy guiding significance for tumor diagnosing, staging, and prognosing, therapeutic evaluation, which is more sensitive in detecting primary lesion and metastases. Compared with PET-CT, there is no radiation, without injection of contrast agent, and WB-DWI is more convenient and economic, so it is more suitable for cancer patients to evaluate response to neoadjuvant therapy and take long-term follow-up after operation and tumor screening of healthy crowd.
[Keywords] Diffusion magnetic resonance imaging；Neoplasm metastasis

GONG Jia-ying Department of Radiology, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510655, China

ZHOU Zhi-yang * Department of Radiology, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510655, China

Deng Yan-hong Department of Medical Ooncology, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510630, China

Kang Liang Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510630, China

CAO Wu-teng Department of Radiology, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510655, China

LIAN Yan-bang Department of Radiology, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510655, China

QIU Jian-ping Department of Radiology, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510655, China

XIONG Fei Department of Radiology, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510655, China

LI Wen-ru Department of Radiology, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510655, China

LI Wen-li Department of Radiology, The Sixth Affiliated Hospital of Sun Yat Sen University, Guangzhou 510655, China

*Correspondence to: Zhou ZY, Email: zhouzyang@hotmail.com

Conflicts of interest   None.

Received  2013-08-20
Accepted  2013-10-08
DOI: 10.3969/j.issn.1674-8034.2013.06.005
DOI:10.3969/j.issn.1674-8034.2013.06.005.

[1]
Rybak LD, Rosenthal DI. Radiological imaging for the diagnosis of bone metastases. Q J Nucl Med, 2001, 45(1): 53-64.
[2]
Li S, Sun F, Jin ZY, et al. Whole-body diffusion-weighted imaging: technical improvement and preliminary results. J Magn Reson Imaging, 2007, 26(4): 1139-1144.
[3]
Kellenberger CJ, Epelman M, Miller SF, et al. Fast STIR whole-body MR imaging in children. Radiographics, 2004, 24(5): 1317-1330.
[4]
Takahara T, Imai Y, Yamashita T, et al. Diffusion weighted whole body imaging with background body signal suppression (DWIBS): technical improvement using free breathing, STIR and high resolution 3D display. Radiat Med, 2004, 22(4): 275-282.
[5]
焦志云，李澄，陈文娟．核磁共振全身弥散加权成像技术及其临床应用．生物医学工程与临床, 2009, 13(3): 262-268.
[6]
Tien RD, Felsberg GJ, Friedman H, et al. MR imaging of high-grade cerebral gliomas: value of diffusion-weighted echoplanar pulse sequences. AJR Am J Roentgenol, 1994, 162(3): 671-677.
[7]
Kwee TC, Takahara T, Ochiai R, et al. Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS): features and potential applications in oncology. Eur Radiol, 2008, 18(9): 1937-1952.
[8]
Koh DM, Blackledge M, Padhani AR, et al. Whole-body diffusion-weighted MRI: tips, tricks, and pitfalls. AJR Am J Roentgenol, 2012, 199(2): 252-262.
[9]
Lambregts DM, Maas M, Cappendijk VC, et al. Whole-body diffusion-weighted magnetic resonance imaging: current evidence in oncology and potential role in colorectal cancer staging. Eur J Cancer, 2011, 47(14): 2107-2116.
[10]
张妍，王晞星，黄永波，等．磁共振全身弥散加权成像在恶性肿瘤筛查中的应用价值初探．磁共振成像, 2011, 02(3): 205-209.
[11]
De Paepe K, Bevernage C, De Keyzer F, et al. Whole-body diffusion-weighted magnetic resonance imaging at 3 Tesla for early assessment of treatment response in non-Hodgkin lymphoma: a pilot study. Cancer Imaging, 2013, 13: 53-62.
[12]
Ippolito D, Monguzzi L, Guerra L, et al. Response to neoadjuvant therapy in locally advanced rectal cancer: assessment with diffusion-weighted MR imaging and 18FDG PET/CT. Abdom Imaging, 2012, 37(6): 1032-1040.
[13]
Chen Y, Zhong J, Wu H, et al. The clinical application of whole-body diffusion-weighted imaging in the early assessment of chemotherapeutic effects in lymphoma: the initial experience. Magn Reson Imaging, 2012, 30(2): 165-170.
[14]
Liu J, Yang X, Li F, et al. Preliminary study of whole-body diffusion-weighted imaging in detecting pulmonary metastatic lesions from clear cell renal cell carcinoma: comparison with CT. Acta Radiol, 2011, 52(9): 954-963.

PREV Study on memory function impairment and structural MRI in posttraumatic stress disorder
NEXT VISTA-sequence magnetic resonance imaging evaluation of scoliosis
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn