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• Clinical Article •
1H magentic resonance spectroscopy in the diagnoisis of multiple sclerosis
WU Chuan-hua  ZHANG Zhi-guo  XIN De-you 

DOI:10.3969/j.issn.1674-8034.2014.01.005.


[Abstract] Objective: To assess the utility of 1H magentic resonance spectroscopy (1H-MRS) in diagnosing and characterizing multiple sclerosis (MS).Materials and Methods: 1H-MRS was carried out in 29 patients with MS and 29 age-matched healhy control subjects. The areas under the peaks of the metabolites of N-acetylaspartic acid (NAA), creatine (Cr), choline compounds (Cho) and lactic acid (Lac) were calculated. The metabolics of NAA/(Cr+Cho), Cho/Cr and Lac/Cr were compared between the two groups.Results: The value of NAA/(Cr+Cho), Cho/Cr and LAC/Cr of MS group and control group were 0.56, 1.49, 3.35 and 0.78, 1.19, 0.23, respectively. Compared with the control group, NAA/(Cr+Cho) reduced, Cho/Cr and Lac/Cr increased in the MS group, all of which had staistically singnificance (P<0.05).Conclusions: 1H-MRS has high specificity, can provide reliable diagnostic information for early diagnosis of MS, and may have important significance to guide clinical treatment and judging prognosis.
[Keywords] Multiple sclerosis；Brain diseases；Magentic resonance spectroscopy

WU Chuan-hua Department of Radiolgy, Yishui Central Hospital, Linyi City, Shandong Province, Linyi 276400, China

ZHANG Zhi-guo Department of Radiolgy, Yishui Central Hospital, Linyi City, Shandong Province, Linyi 276400, China

XIN De-you Department of Radiolgy, Yishui Central Hospital, Linyi City, Shandong Province, Linyi 276400, China

Conflicts of interest   None.

Received  2013-11-06
Accepted  2013-12-20
DOI: 10.3969/j.issn.1674-8034.2014.01.005
DOI:10.3969/j.issn.1674-8034.2014.01.005.

[1]
Kollia K, Maderwald S, Putzki N, et al. First clinical study on ultra-high-field MR imaging in patients with multiple sclerosis: comparison of 1.5 T and 7.0 T. AJNR Am J Neuroradiol, 2009, 30(4): 699-702
[2]
陈颖，英华.多发性硬化影像学诊断价值.中华实用诊断与治疗杂志, 2010, 24(6): 586-587
[3]
王志康，孙建忠. 1H磁共振波谱的影响因素.实用放射学杂志, 2003, 19(7): 669-670.
[4]
Mcdonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis of multiple sclerosis. Ann Neurol, 2001, 50(1):1271-1277.
[5]
冯逢.多发性硬化的常见MRI征象分析.磁共振成像, 2011, 2(4):309-313.
[6]
刘怀军，李晖，梁莹,等.多发性硬化几个MRI征象的再复习及其意义.磁共振成像, 2011, 2(4): 260-263.
[7]
李郁欣，汤伟军，耿道颖,等. MRS联合DTI技术在多发性硬化中的初步应用.临床放射学杂志, 2008, 27(9): 1145-1149.
[8]
Balashov KE, Aung LL, Dhib-Jalbut S, et al. Acute multiple sclerosis lesion: conversion of restricted diffusion due to vasogenic edema. J Neuroimaging, 2011, 21(2): 202-204.
[9]
Vikhoff-Baaz B, Malmgren K, Jonsson L, et al. Lateralisation with magnetic resonance spectroscopic imaging in temporal lobe epilepsy: an evaluation of visual and region-of-interest analysis of metabolite concentration images. Neuroadiology, 2001, 43(9): 721-727.
[10]
李明智，桂绍高，刘大仁,等.多发性硬化的磁共振波谱研究.实用临床医学, 2008, 9(9): 99-101.
[11]
段云云，李坤成，于春水.多发性硬化的磁共振波谱研究.中国医学影像技术, 2006, 22(1): 67-69.
[12]
陈世林，罗明月，陈少琼,等.多发性硬化1H磁共振波谱分析.临床放射学杂志, 2010, 29(1): 18-21.
[13]
Clarke CE, Lowry M. Systematic review of proton magnetic resonance spectroscopy of the striatum in parkinsonian syndromes. Eur J Neurol, 2001, 8(6): 573-577.

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