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• Clinical Article •
1H magentic resonance spectroscopy in the diagnoisis of multiple sclerosis
WU Chuan-hua  ZHANG Zhi-guo  XIN De-you 

DOI:10.3969/j.issn.1674-8034.2014.01.005.


[Abstract] Objective: To assess the utility of 1H magentic resonance spectroscopy (1H-MRS) in diagnosing and characterizing multiple sclerosis (MS).Materials and Methods: 1H-MRS was carried out in 29 patients with MS and 29 age-matched healhy control subjects. The areas under the peaks of the metabolites of N-acetylaspartic acid (NAA), creatine (Cr), choline compounds (Cho) and lactic acid (Lac) were calculated. The metabolics of NAA/(Cr+Cho), Cho/Cr and Lac/Cr were compared between the two groups.Results: The value of NAA/(Cr+Cho), Cho/Cr and LAC/Cr of MS group and control group were 0.56, 1.49, 3.35 and 0.78, 1.19, 0.23, respectively. Compared with the control group, NAA/(Cr+Cho) reduced, Cho/Cr and Lac/Cr increased in the MS group, all of which had staistically singnificance (P<0.05).Conclusions: 1H-MRS has high specificity, can provide reliable diagnostic information for early diagnosis of MS, and may have important significance to guide clinical treatment and judging prognosis.
[Keywords] Multiple sclerosis；Brain diseases；Magentic resonance spectroscopy

WU Chuan-hua Department of Radiolgy, Yishui Central Hospital, Linyi City, Shandong Province, Linyi 276400, China

ZHANG Zhi-guo Department of Radiolgy, Yishui Central Hospital, Linyi City, Shandong Province, Linyi 276400, China

XIN De-you Department of Radiolgy, Yishui Central Hospital, Linyi City, Shandong Province, Linyi 276400, China

Conflicts of interest   None.

Received  2013-11-06
Accepted  2013-12-20
DOI: 10.3969/j.issn.1674-8034.2014.01.005
DOI:10.3969/j.issn.1674-8034.2014.01.005.

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