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• Clinical Article •
White matter variations in preterm and full term neonates with punctate white matter lesions: a diffusion tensor study based on tract-based spatial statistics
GAO Jie  ZHANG Yu-miao  SUN Qin-li  LI Xian-jun  LI Yan-yan  YU Bo-lang  YANG Jian 

DOI:10.3969/j.issn.1674-8034.2014.01.006.


[Abstract] Objective: The aim of this diffusion tensor imaging (DTI) study was to explore the white matter (WM) variations due to punctate white matter lesions (PWML) in preterm and full term neonates using tract-based spatial statistics (TBSS) analysis.Materials and Methods: 21 preterm and 25 full term patients with matched control neonates who underwent conventional MRI and DTI were enrolled. The differences of fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD) and mean diffusivity (MD) values between PWML group and paired control group were analyzed by using TBSS in preterm and full term neonates separately.Results: In both full term and preterm neonates with PWML, FA decreased significantly in optic radiation (OR), posterior limb of internal capsule (PLIC), splenium of the corpus callosum (SCC) and body of the corpus callosum (BCC). Unlike single FA decrease in preterm neonates, RD and MD increased while FA decreased in full term neonates. Additional impaired WMs could be observed in full term neonates in genu of corpus callosum (GCC), corona radiate (CR), anterior and posterior central gyrus (ACS & PCS).Conclusions: The white matter (WM) variations due to neonatal PWML were not limited in the regions where these lesions located, and they were different between preterm and full term neonates in the distribution and extent.
[Keywords] Punctate white matter lesion；Infant, newborn；Magnetic resonance imaging

GAO Jie Department of Radiology, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, China

ZHANG Yu-miao Department of Radiology, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, China

SUN Qin-li Department of Radiology, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, China

LI Xian-jun Department of Radiology, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, China

LI Yan-yan Department of Radiology, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, China

YU Bo-lang Department of Radiology, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, China

YANG Jian* Department of Radiology, the First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710061, China

*Correspondence to: Yang J, E-mail: cjr.yangjian@vip.163.com

Conflicts of interest   None.

Received  2013-12-02
Accepted  2013-12-26
DOI: 10.3969/j.issn.1674-8034.2014.01.006
DOI:10.3969/j.issn.1674-8034.2014.01.006.

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