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• Clinical Article •
The value of quantitative dynamic-enhanced MRI in evaluating extra-ocular muscle involvement in patients with chronic thyroid-associated ophthalmopathy
HUO Lei  YAN Shuo  WANG Jian  SHEN Wen  XIA Shuang 

DOI:10.3969/j.issn.1674-8034.2014.01.007.


[Abstract] Objective: To evaluate retrospectively dynamic-enhanced MRI (DCE-MRI) features of involved extra-ocular muscle in patiens with chronic thyroid-associated ophthalmopathy (TAO).Materials and Methods: MRI examination were performed on 17 patients with chronic TAO and 27 healthy controls. Parameters of extra-ocular muscles of patients and controls, including Ktrans, Kep, Ve, IAUC, were produced by post process software. ROIs were drawn slice by slice along the edge of muscle belly, and repeated one month later.Results: There were no statistical difference between left and right muscles both in patients and controls (P>0.05). The mean values of Ktrans, Kep, IAUC of medial rectus and mean values of Ktrans, Kep, Ve value of inferior rectus in patiets were lower than those of healthy controls (P<0.05). The mean values of Kep, Ve, IAUC of superior rectus muscle complex in patients were higher than those of controls (P<0.05). There were no statistic differences in mean value of Ktrans, Kep, Ve, IAUC of lateral rectus and the mean value of Ve of medial rectus, the mean value of IAUC of inferior rectus and the mean value of Ktrans of superior rectus muscle complex between patients and controls (P>0.05). Among the all quantitative parameters, the mean value of Ktrans was most sensitive (The area under ROC curve of Ktrans was 0.753 in medial rectus and 0.650 in inferior rectus).Conclusions: DCE-MRI could be applied to evaluate extra-ocular muscles involvement in patients with chronic TAO. The medial rectus muscle and the inferior rectus muscle were most commonly involved in patients with TAO. The mean value of Ktrans value could be used to reflect the microcirculatory perfusion.
[Keywords] Thyroid-associated ophthalmopathy；Magnetic resonance imaging

HUO Lei Department of Radiology, Tianjin Medical University the First Center Hospital Institute, Tianjin 300192, China

YAN Shuo Department of Radiology, Tianjin Medical University the First Center Hospital Institute, Tianjin 300192, China

WANG Jian Department of Radiology, Tianjin Medical University the First Center Hospital Institute, Tianjin 300192, China

SHEN Wen* Department of Radiology, Tianjin Medical University the First Center Hospital Institute, Tianjin 300192, China

XIA Shuang Department of Radiology, Tianjin Medical University the First Center Hospital Institute, Tianjin 300192, China

*Correspondence to: Shen W, E-mail: shenwen66@163.com

Conflicts of interest   None.

Received  2013-10-10
Accepted  2013-11-22
DOI: 10.3969/j.issn.1674-8034.2014.01.007
DOI:10.3969/j.issn.1674-8034.2014.01.007.

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