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• Clinical Article •
Preliminary study on pathomechanism of non-small-cell lung carcinoma using apparent diffusion coefficient
CHEN Ai-ping  LI Hui-min  YU Hong  LIU Shi-yuan  XIAO Xiang-sheng 

DOI:10.3969/j.issn.1674-8034.2014.01.009.


[Abstract] Objective: To investigate the value of apparent diffusion coefficient (ADC) in predicting the pathomechanism of non-small-cell lung carcinoma (NSCLC).Materials and Methods: Four-six patients with NSCLC conformed by histopathology were examined with diffusion weighting imaging (DWI). ADCs were calculated on multiple b-value imaging. Correlations between the ADCs and tumor cellularity, nuclear-cytoplasmic ratio and nuclear-kytoplasm ratio were analysed by Pearson rank correlation.Results: The ADCs of NSCLC correlated negatively with tumorous cellular density on multiple b-value imaging and as b was 300 s/mm2,which can achieve the best correlation (b=300 s/mm2, r=-0.792, P<0.01). There were inverse correlations between ADCs and nuclear-cytoplasmic ratio, nuclear-kytoplasm ratio (b=300 s/mm2, r=-0.739, P<0.01, -0.607, P=0.0187, respectively).Conclusions: Preliminary results revealed the ADCs of NSCLC had close correlation with tumorous histopathology characteristic.
[Keywords] Carcinoma, non-small-cell lung；Diffusion magnetic resonance imaging

CHEN Ai-ping Department of Radiology, the First Affiliated Hospital of Nan Jing Medical University, Nanjing 210029, China

LI Hui-min Department of Radiology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China

YU Hong Department of Radiology, Changzheng Hospital Affiliated to the Second Military Medical University, Shanghai 200003, China

LIU Shi-yuan Department of Radiology, Changzheng Hospital Affiliated to the Second Military Medical University, Shanghai 200003, China

XIAO Xiang-sheng* Department of Radiology, Changzheng Hospital Affiliated to the Second Military Medical University, Shanghai 200003, China

*Correspondence to: Xiao XS, E-mail: cjr.xiaoxiangsheng@VIP.163.com

Conflicts of interest   None.

Received  2013-10-17
Accepted  2013-12-10
DOI: 10.3969/j.issn.1674-8034.2014.01.009
DOI:10.3969/j.issn.1674-8034.2014.01.009.

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