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• Original Article •
Quantitative assessment of hyperacute ischemic stroke onset time window
YAN Gen  ZHAO Da-wei  DAI Zhuo-zhi  JIA Yan-long  GENG Kuan  XUAN Ying-hua  WU Ren-hua 

DOI:10.3969/j.issn.1674-8034.2014.01.012.


[Abstract] Objective: To assess and quantify the ischemic onset time window of middle cerebral artery infarction hyperacute stroke of MCAO rat model at 7.0 T MRI diffusion weighted imaging (DWI) and by proton magnetic resonance spectrum (1H MRS).Materials and Methods: Diffusion-weighted imaging (DWI) and conventional T2WI were employed on 10 cases of MCAO rat model in measuring the average ADC lesion at different time periods. Quantification of local changes in the concentrations of metabolites within the lesions at different time zones was performed using magnetic resonance spectrum.Results: High signal area appeared half an hour after occlusion in DWI (100%). No abnormal signal was observed in 6 hours with general T2WI. 1H MRS display was consistent with elevated lactate (Lac) and reduced n-acetyl aspartic acid salt (NAA). Glutamate and taurine reached a maximum in rats 2 h after MCAO but began to decrease 3 h after MCAO.Conclusions: Hyperacute cerebral infarction can be pointed out with the application of T2WI, DWI and 1H MRS. These methods may also be used to assess quantitatively the ischemic onset time of a hyperacute stroke.
[Keywords] Cerebrovascular accident；Magnetic resonance spectroscopy；Diffusion magnetic resonance imaging；Animals laboratory

YAN Gen Department of Radiology, the Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China

ZHAO Da-wei Department of Radiology, the Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China

DAI Zhuo-zhi Department of Radiology, the Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China

JIA Yan-long Department of Radiology, the Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China

GENG Kuan Department of Radiology, the Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China

XUAN Ying-hua Department of Radiology, the Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China

WU Ren-hua* Department of Radiology, the Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China

*Correspondence to: Wu RH, E-mail: rhwu@stu.edu.cn

Conflicts of interest   None.

Received  2013-11-20
Accepted  2013-12-19
DOI: 10.3969/j.issn.1674-8034.2014.01.012
DOI:10.3969/j.issn.1674-8034.2014.01.012.

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