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• Original Article •
Quantitative assessment of hyperacute ischemic stroke onset time window
YAN Gen  ZHAO Da-wei  DAI Zhuo-zhi  JIA Yan-long  GENG Kuan  XUAN Ying-hua  WU Ren-hua 

DOI:10.3969/j.issn.1674-8034.2014.01.012.


[Abstract] Objective: To assess and quantify the ischemic onset time window of middle cerebral artery infarction hyperacute stroke of MCAO rat model at 7.0 T MRI diffusion weighted imaging (DWI) and by proton magnetic resonance spectrum (1H MRS).Materials and Methods: Diffusion-weighted imaging (DWI) and conventional T2WI were employed on 10 cases of MCAO rat model in measuring the average ADC lesion at different time periods. Quantification of local changes in the concentrations of metabolites within the lesions at different time zones was performed using magnetic resonance spectrum.Results: High signal area appeared half an hour after occlusion in DWI (100%). No abnormal signal was observed in 6 hours with general T2WI. 1H MRS display was consistent with elevated lactate (Lac) and reduced n-acetyl aspartic acid salt (NAA). Glutamate and taurine reached a maximum in rats 2 h after MCAO but began to decrease 3 h after MCAO.Conclusions: Hyperacute cerebral infarction can be pointed out with the application of T2WI, DWI and 1H MRS. These methods may also be used to assess quantitatively the ischemic onset time of a hyperacute stroke.
[Keywords] Cerebrovascular accident；Magnetic resonance spectroscopy；Diffusion magnetic resonance imaging；Animals laboratory

YAN Gen Department of Radiology, the Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China

ZHAO Da-wei Department of Radiology, the Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China

DAI Zhuo-zhi Department of Radiology, the Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China

JIA Yan-long Department of Radiology, the Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China

GENG Kuan Department of Radiology, the Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China

XUAN Ying-hua Department of Radiology, the Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China

WU Ren-hua* Department of Radiology, the Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China

*Correspondence to: Wu RH, E-mail: rhwu@stu.edu.cn

Conflicts of interest   None.

Received  2013-11-20
Accepted  2013-12-19
DOI: 10.3969/j.issn.1674-8034.2014.01.012
DOI:10.3969/j.issn.1674-8034.2014.01.012.

[1]
Jauch EC, Saver JL, Adams HP, et al. Guidelines for the early management of patients with acute ischemic stroke a guideline for healthcare professionals from the american heart association american stroke association. Stroke, 2013, 44(3): 870-947.
[2]
Bahn MM, Oser AB, Cross DT, et al. CT and MRI of stroke. J Magnet Reson Imaging, 1996, 6(5): 833-845.
[3]
刘怀军，张岩，杨冀萍.脑缺血的CT、MRI表现及其理解.磁共振成像, 2013, 4(1): 47-58.
[4]
Lutsep H, Albers G, DeCrespigny A, et al. Clinical utility of diffusion©\weighted magnetic resonance imaging in the assessment of ischemic stroke. Ann neurol, 1997, 41(5): 574-580.
[5]
Löuvbld KO, Baird AE, Schlaug G, et al. Ischemic lesion volumes in acute stroke by diffusion weighted magnetic resonance imaging correlate with clinical outcome. Ann neurol, 1997, 42(2): 164-170.
[6]
Longa EZ, Weinstein PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke, 1989, 20(1):84-91.
[7]
Provencher SW. Automatic quantitation of localizedin vivo1h spectra with lcmodel. NMR Biomed, 2001, 14(2): 260-264.
[8]
Tong D, Yenari M, Albers G, et al. Correlation of perfusion and diffusion weighted MRI with nihss score in acute (< 6.5 hour) ischemic stroke. Neurology, 1998, 50(4): 864-869.
[9]
Neumann-Haefelin T, Wittsack HJ, Wenserski F, et al. Diffusion-and perfusion-weighted MRI the DWI/PWI mismatch region in acute stroke. Stroke, 1999, 30(2): 1591-1597.
[10]
Rordorf G, Koroshetz WJ, Copen WA, et al. Regional ischemia and ischemic injury in patients with acute middle cerebral artery stroke as defined by early diffusion-weighted and perfusion-weighted MRI. Stroke, 1998, 29(5): 939-943.
[11]
Schellinger P, Bryan R, Caplan L, et al. Evidence-based guideline: the role of diffusion and perfusion MRI for the diagnosis of acute ischemic stroke report of the therapeutics and technology assessment subcommittee of the american academy of neurology. Neurology, 2010, 75(1): 177-185.
[12]
Fiebach J, Schellinger P, Jansen O, et al. CT and diffusion-weighted MR imaging in randomized order diffusion-weighted imaging results in higher accuracy and lower interrater variability in the diagnosis of hyperacute ischemic stroke. Stroke, 2002, 33(9): 2206-2210.
[13]
Jayakumar PN, Gangadhar BN, Venkatasubramanian G, et al. High energy phosphate abnormalities normalize after antipsychotic treatment in schizophrenia: a longitudinal 31P MRS study of basal ganglia. Psychiatry Res, 2010, 181(3): 237-240.
[14]
彭娟，罗天友，吕发金,等.质子MRS脂质峰升高在颅内疾病鉴别诊断的价值.磁共振成像, 2011, 2(1): 50-54.
[15]
Marsman A, van den Heuvel MP, Klomp DW, et al. Glutamate in schizophrenia: a focused review and meta-analysis of 1H-MRS studies. Schizophren bull, 2013, 39(1): 120-129.
[16]
van der Toorn A, Dijkhuizen RM, Tulleken CA, et al. Diffusion of metabolites in normal and ischemic rat brain measured by localized 1H MRS. Magnet Reson Med, 1996, 36(6): 914-922.
[17]
Cvoro V, Wardlaw JM, Marshall I, et al. Associations between diffusion and perfusion parameters, n-acetyl aspartate, and lactate in acute ischemic stroke. Stroke, 2009, 40(3): 767-772.
[18]
Higuchi T, Fernandez EJ, Maudsley AA, et al. Mapping of lactate and n-acetyl-l-aspartate predicts infarction during acute focal ischemia: in vivo 1H magnetic resonance spectroscopy in rats. Neurosurgery, 1996,38(1): 121-130.

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