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• Clinical Article •
Olfactory deficit detected by fMRI in vascular dementia patients
JI Dong-xu  ZHAO Bo-feng  SONG Yang  NI Hong-yan  YIN Jian-zhong 

DOI:10.3969/j.issn.1674-8034.2014.02.001.


[Abstract] Objective: The olfactory functional MRI (fMRI) was used to investigate the olfactory deficiency in the vascular dementia (VaD).Materials and Methods: 15 normal elderly people (NC group) and 12 VaD (VaD group) patients underwent MMSE, MOCA, CDR and Hachinsk grades. All subjects were scanned by Siemens 3.0 T MRI scanner, with 32 channel head coil, all olfactory fMRI data were processed with 64 bit Matlab 7.11.0 and SPM8 softwares. The independent samples t-test was used to analyze these two groups.Results: Inter-group analysis between two samples showed that the activated voxels in the whole brain of NC group were significantly higher than the VaD group, the activated area was mainly located in the frontal lobe, temporal lobe and the medial frontal gyrus.Conclusion: The VaD patients also suffered olfactory deficit, the olfactory fMRI can evaluate the olfactory function of VaD patients, which is a potential method to the study of the neurodegenerative diseases with olfactory deficit.
[Keywords] Dementia, vascular；Olfaction disorders；Magnetic resonance imaging；Primary olfactory cortex

JI Dong-xu Radiology Department, Tianjin First Central Hospital, Tianjin Medical University, Tianjin Medical Imaging Institute, Tianjin 300192, China

ZHAO Bo-feng Radiology Department, Tianjin First Central Hospital, Tianjin Medical University, Tianjin Medical Imaging Institute, Tianjin 300192, China

SONG Yang Neurology Department, Tianjin First Central Hospital, Tianjin Medical University, Tianjin Medical Imaging Institute, Tianjin 300192, China

NI Hong-yan Radiology Department, Tianjin First Central Hospital, Tianjin Medical University, Tianjin Medical Imaging Institute, Tianjin 300192, China

YIN Jian-zhong* Radiology Department, Tianjin First Central Hospital, Tianjin Medical University, Tianjin Medical Imaging Institute, Tianjin 300192, China

*Correspondence to: Yin JZ, E-mail: Jianzhong.yin@gmail.com

Conflicts of interest   None.

Received  2014-01-18
Accepted  2014-02-16
DOI: 10.3969/j.issn.1674-8034.2014.02.001
DOI:10.3969/j.issn.1674-8034.2014.02.001.

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