Share：
Share this content in WeChat
X
[Chinese][PDF]80486
• Clinical Article •
Evaluation of combined DTI and MRS to glioblastoma before and after radiotherapy
LI Jun  ZHANG Xue-yan  JIANG Xing-yue  ZHANG Lin  WANG Qi  XIA Ji-kai  LI Quan 

DOI:10.3969/j.issn.1674-8034.2014.02.002.


[Abstract] Objective: To discuss the value of diffusion tensor imaging (DTI) in combination with magnetic resonance spectroscopy (MRS) in glioblastoma before and after radiotherapy.Materials and Methods: 8 patients with recurrent glioblastoma confirmed by pathological method were selected to receive conventional MRI, contrast-enhanced scanning, DTI and MRS sequence scan before and after radiotherapy. The fractional anisotropy (FA) value, apparent diffusion coefficient (ADC) value metabolite ratios including NAA/Cr, Cho/Cr, Lip/Cr were measured according to different regions including tumor parenchyma, peritumoral edema. All the data were analyzed by paired-samples t test.Results: The ADC value of tumor parenchyma after radiotherapy increased compared to that before radiotherapy (t=3.320, P=0.013). Cho/Cr of tumor parenchyma after radiotherapy decreased compared to that before radiotherapy (t=2.960, P=0.021). Cho/Cr of peritumoral edema after radiotherapy decreased compared to that before radiotherapy (t=2.867, P=0.024).Conclusions: Combined application of DTI and MRS contribute to reflect changes post radiotherapy and can be used to monitor and evaluate the effect of radiotherapy.
[Keywords] Glioblastoma；Magnatic resonance imaging；Magnetic resonance spectroscopy；Radiotherapy

LI Jun Department of Radiology, Affiliated Hospital of Binzhou Medical University, Binzhou, 256603, China

ZHANG Xue-yan* Nursing College of Binzhou Medical University, Yantai 264003, China

JIANG Xing-yue Department of Radiology, Affiliated Hospital of Binzhou Medical University, Binzhou, 256603, China

ZHANG Lin Department of Radiology, Affiliated Hospital of Binzhou Medical University, Binzhou, 256603, China

WANG Qi Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264100, China

XIA Ji-kai Department of Radiology, Affiliated Hospital of Binzhou Medical University, Binzhou, 256603, China

LI Quan Department of Radiology, Affiliated Hospital of Binzhou Medical University, Binzhou, 256603, China

*Correspondence to: Zhang XY, E-mail: z.xyd@163.com

Conflicts of interest   None.

Received  2013-11-06
Accepted  2014-01-30
DOI: 10.3969/j.issn.1674-8034.2014.02.002
DOI:10.3969/j.issn.1674-8034.2014.02.002.

[1]
曹朋，史克珊，李钢,等.胶质瘤瘤周水肿的磁共振波谱和弥散张量成像研究进展.中华神经医学杂志, 2011, 10(6): 643-645.
[2]
吴静，戴建平，江涛,等.多形性胶质母细胞瘤MR弥散张量成像应用研究.中国医学影像技术, 2008, 24(7): 992-995.
[3]
Kinoshita M, Goto T, Okita Y, et a1. Differentiation of pure vasogenic edema and tumor-infiltrated edema in patients with peritumoral edema by analyzing the relationship of axial and radial diffusivities on 3.0 T MRI. J Neurooncol, 2010, 96(3): 409-415.
[4]
Nimsky C, Ganslandt O, Fahlbusch R. Implementation of fiber tract navigation. Neurosurgery, 2007, 6l(Suppl 1): 306-317.
[5]
Engelhorn T, Savaskan NE, Schwarz MA, et al. Cellular characterization of the peritumoral edema zone in malignant brain tumors. Cancer Sci, 2009, 100(10): 1856-1862.
[6]
Cheng LL, Anthony DC, Comite AR, et a1. Quantification of microheterogeneity in glioblastoma multiforme with ex vivo high-resolution magic-angle spinning (HRMAS) proton magnetic resonance spectroscopy. Neuro Oncol, 2000, 2(2): 87-95.
[7]
Provenzale JM, McGraw P, Mhatre P, et al. Peritumoral brain regions in gliomas and meningiomas: investigation with isotropic diffusion-weighted MR imaging and diffusion-tensor MR imaging. Radiology, 2004, 232(2): 451-460.
[8]
Bieza A, Krumina G. Magnetic resonance study on fractional anisotropy and neuronal metabolite ratios in peritumoral area of cerebral gliomas. Medicina (Kaunas), 2012, 48(10): 497-506.
[9]
Kallenberg K, Goldmann T, Menke J, et a1. Glioma infiltration of the corpus callosum: early signs detected by DTI. J Neurooncol, 2013,112(2): 217-222.
[10]
钱银锋，殷敏敏，余永强.扩散加权成像在低级别胶质瘤的鉴别诊断价值.磁共振成像, 2010, 1(1): 19-22.
[11]
胡鸿博，刘鹏飞.磁共振弥散张量成像及纤维束成像对脑胶质瘤分级的诊断价值.磁共振成像, 2011, 2(2): 118-122.
[12]
黄仁华，廖志军，徐欣,等. MRS和DTI对放疗前后脑胶质瘤瘤周水肿的观察与分析.中国中西医结合影像学杂志, 2013, 11(1): 4-6.
[13]
Tedeschi G, Lundbom N, Raman R, et a1. Increased choline signal coinciding with malignant degeneration of cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study. J Neurosurg, 1997, 87(4): 516-524.

PREV Olfactory deficit detected by fMRI in vascular dementia patients
NEXT The comparative study of CT and MRI about brain anatomic microstructure anomalous changes on assess and predict cerebral ischemia
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn