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• Clinical Article •
Evaluation of combined DTI and MRS to glioblastoma before and after radiotherapy
LI Jun  ZHANG Xue-yan  JIANG Xing-yue  ZHANG Lin  WANG Qi  XIA Ji-kai  LI Quan 

DOI:10.3969/j.issn.1674-8034.2014.02.002.


[Abstract] Objective: To discuss the value of diffusion tensor imaging (DTI) in combination with magnetic resonance spectroscopy (MRS) in glioblastoma before and after radiotherapy.Materials and Methods: 8 patients with recurrent glioblastoma confirmed by pathological method were selected to receive conventional MRI, contrast-enhanced scanning, DTI and MRS sequence scan before and after radiotherapy. The fractional anisotropy (FA) value, apparent diffusion coefficient (ADC) value metabolite ratios including NAA/Cr, Cho/Cr, Lip/Cr were measured according to different regions including tumor parenchyma, peritumoral edema. All the data were analyzed by paired-samples t test.Results: The ADC value of tumor parenchyma after radiotherapy increased compared to that before radiotherapy (t=3.320, P=0.013). Cho/Cr of tumor parenchyma after radiotherapy decreased compared to that before radiotherapy (t=2.960, P=0.021). Cho/Cr of peritumoral edema after radiotherapy decreased compared to that before radiotherapy (t=2.867, P=0.024).Conclusions: Combined application of DTI and MRS contribute to reflect changes post radiotherapy and can be used to monitor and evaluate the effect of radiotherapy.
[Keywords] Glioblastoma；Magnatic resonance imaging；Magnetic resonance spectroscopy；Radiotherapy

LI Jun Department of Radiology, Affiliated Hospital of Binzhou Medical University, Binzhou, 256603, China

ZHANG Xue-yan* Nursing College of Binzhou Medical University, Yantai 264003, China

JIANG Xing-yue Department of Radiology, Affiliated Hospital of Binzhou Medical University, Binzhou, 256603, China

ZHANG Lin Department of Radiology, Affiliated Hospital of Binzhou Medical University, Binzhou, 256603, China

WANG Qi Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264100, China

XIA Ji-kai Department of Radiology, Affiliated Hospital of Binzhou Medical University, Binzhou, 256603, China

LI Quan Department of Radiology, Affiliated Hospital of Binzhou Medical University, Binzhou, 256603, China

*Correspondence to: Zhang XY, E-mail: z.xyd@163.com

Conflicts of interest   None.

Received  2013-11-06
Accepted  2014-01-30
DOI: 10.3969/j.issn.1674-8034.2014.02.002
DOI:10.3969/j.issn.1674-8034.2014.02.002.

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