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• Clinical Article •
Comparison of fitting degree in monoexponential and biexponential model used to assess multi b-value DWI of renal parenchyma and CCRCC
WANG Xue-yuan  XING Wei  HU Chun-hong  DING Jiu-le  CHEN Jie  SUN Jun 

DOI:10.3969/j.issn.1674-8034.2014.02.004.


[Abstract] Objective: To explore a more suitable mathematical model describing the signal change of renal parenchyma and clear cell renal cell carcinoma (CCRCC) induced from DWI with several b values.Materials and Methods: The images of 32 cases with CCRCC was analyzed retrospectively. Base on the conventional sequences, the signal intensity of renal parenchyma and CCRCC were measured, and the trends of signal intensity with several b values were fitted using two methods respectively, including monoexponential model (Group 1) and biexponential model (Group 2), and the quantitative index R2 was calculated. The R2 was compared between two groups using Wilcoxon test and between two tissues using Mann-Whitney test.Results: The signal intensity of two tissues declined with increased b values. The R2 was shown as median (75% CI). In tumor, the R2 is 0.97 (0.96, 1.00) in Group 1 and 1.00 (1.00, 1.00) in Group 2, and a significant difference was found (W=-253, P=0.00). In renal parenchyma, the R2 is 0.98 (0.98, 0.99) in Group 1 and 1.00 (1.00, 1.00) in Group 2, and there is a statistical difference (W=-528, P=0.00). And there are no differences between two tissues using each exponential modal (U=301.5, P=0.26, U=253.0, P=0.05, respectively).Conclusion: The biexponential function is a more suitable mathematical model for describing the signal change of renal parenchyma and CCRCC on DW imaging with several b values.
[Keywords] Diffusion magnetic resonance imaging；Kidney neoplasms；Adenocarcinoma, clear cell

WANG Xue-yuan Department of Radiology, First Affiliated Hospital of Soochow University, Suzhou 215000, China

XING Wei* Department of Radiology, Third Affiliated Hospital of Soochow University, Changzhou 213003, China

HU Chun-hong Department of Radiology, First Affiliated Hospital of Soochow University, Suzhou 215000, China

DING Jiu-le Department of Radiology, Third Affiliated Hospital of Soochow University, Changzhou 213003, China

CHEN Jie Department of Radiology, Third Affiliated Hospital of Soochow University, Changzhou 213003, China

SUN Jun Department of Radiology, Third Affiliated Hospital of Soochow University, Changzhou 213003, China

*Correspondence to: Xing W, E-mail: suzhxingwei@126.com

Conflicts of interest   None.

Received  2013-12-02
Accepted  2014-01-04
DOI: 10.3969/j.issn.1674-8034.2014.02.004
DOI:10.3969/j.issn.1674-8034.2014.02.004.

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