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• Clinical Article •
Relationships between 3.0 T MRI features and prognostic factors of patients in breast invasive ductal carcinoma
WANG Ying-ying  CHANG Xiao-dan  FU Jiao-hui 

DOI:10.3969/j.issn.1674-8034.2014.02.010.


[Abstract] Objective: The aim of the current study was to correlate Magnetic resonance features with prognostic factors in breast invasive ductal carcinoma.Materials and Methods: 128 cases with primary breast invasive ductal carcinoma underwent magnetic resonance prior to surgery. Magnetic resonance features of breast cancer were determined based on the Breast Imaging and Reporting Data System (BI-RADS). MRI characteristics of our study included tumor shape, margin, type of enhancement, time to peak (Tpeak), Signal enhancement ratio (SER), Time intensity curve (TIC) and apparent diffusion coefficient (ADC), rADC. Histological specimens were analyzed after surgery for expression of estrogen receptor (ER), expression of progesterone receptor (PR), and expression of Her-2, Ki-67. These patients were all women, the mean age of them was 49±9.6 (ranging 28 to 76 years). All the patients had exactly the same MR sequences and parameters. The MRI scans were acquired with the patient prone position in a 3.0 T scanner (Magnetom Verio, Siemens Medical Solutions, Erlangen, Germany) equipped with a dedicated surface breast coil. All images were obtained in a workstation. Two breast radiologists retrospectively analyzed the imaging findings, and any discrepancy was resolved by consensus. Correlations between the MR features and prognostic factors were analyzed using the Spearman rank correlation. Logistic regression was performed for the analysis Spearman rank correlations to identify the most significant and independent MR image findings that were correlated with the prognostic factors. The above-mentioned statistical analyses were performed with SPSS 19.0.Results: Statistical analysis showed that Lobulate was associated with the negative expression of Ki67 (P=0.014).The rim enhancement of the mass was also associated with negative expression of ER (P=0.002), negative expression of PR (P=0.016). There was a significant association between the type III of TIC and the expression of Ki67 (P=0.012).Conclusions: To a certain extent there is some correlation among the MRI features, pathology, and prognostic factors in breast invasive ductal carcinoma. The biological behavior and prognosis of breast invasive ductal carcinoma be assessed based on MRI features. Lobulate shape,rim enhancement and the type III of TIC of the breast invasive ductal carcinoma were associated with a poor prognosis.
[Keywords] Breast neoplasms；Magnetic resonance imaging；Prognosis

WANG Ying-ying Department of Radiology, Dalian University, Zhongshan Hospital, Dalian 116001, China

CHANG Xiao-dan* Department of Radiology, Dalian University, Zhongshan Hospital, Dalian 116001, China

FU Jiao-hui Department of Radiology, Dalian University, Zhongshan Hospital, Dalian 116001, China

*Correspondence to: Chang XD, E-mail: 13384111832@163.com

Conflicts of interest   None.

Received  2013-12-31
Accepted  2014-01-28
DOI: 10.3969/j.issn.1674-8034.2014.02.010
DOI:10.3969/j.issn.1674-8034.2014.02.010.

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