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• Clinical Article •
A preliminary study of 3-dimensional pseudocontinous arterial spin labeling in WHO grade II gliomas subtyping
XIAO Hua-feng  YI Yan  AN Wei-min  TIAN Shu-ping  WANG Yu-lin  MA Wei 

DOI:10.3969/j.issn.1674-8034.2014.03.001.


[Abstract] Objective: Different subtypes of gliomas present different prognosis and different response to therapy. To retrospectively analyses the differentiating diagnostic accuracy of 3-dimensional pseudocontinous arterial spin labeling (3D-PCASL) in the prediction of WHO grade II gliomas subtyping, and to appraise normalized lesion/normal tissue cerebral blood flow (nCBF) with histological findings as a reference standard.Materials and Methods: 34 patients with pathologically proved WHO grade II gliomas underwent conventional magnetic resonance sequences, 3-dimensional pseudocontinuous arterial spin labeling (3D-PCASL) and post-contrast MR imaging. Representative maximal nCBF originated from 3D-PCASL regions of interest were chosen and measured from each lesion. These parameters were used for statistical evaluation according to histopathological result to group astrocytomas (n=16), oligodendrogliomas (n=13) and oligoastrocytomas (n=5).Results: The mean nCBF ratio (1.213±0.506) of astrocytomas was slightly lower than that (1.283±1.414) of oligodendragliomas group. There was no significant difference between both groups for mean nCBF ratio (P=0.854). Without enough sample of oligoastrocytoma group, it was excluded for statistic analysis.Conclusions: There was no obvious difference in perfusion between the different subtypes of WHO grade II gliomas. It should be too early to say that 3D-PCASL is a valuable method for differentiating diagnosis different subtypes of WHO grade II gliomas which will be elucidated in further study.
[Keywords] Magnetic resonance imaging；Glioma

XIAO Hua-feng Departments of Radiology, PLA 302 Hospital, Beijing 100039, China

YI Yan Laboratory Animal Center, Academy of Military Medical Sciences, Beijing 100071, China

AN Wei-min* Departments of Radiology, PLA 302 Hospital, Beijing 100039, China

TIAN Shu-ping Departments of Radiology, Navy General Hospital, Beijing 100048, China

WANG Yu-lin Departments of Radiology, PLA General Hospital, Beijing 100853, China Joint first authors: YI Yan

MA Wei Departments of Radiology, PLA 302 Hospital, Beijing 100039, China

*Correspondence to: An WM, E-mail: anweimin@icloud.com

Conflicts of interest   None.

Received  2014-01-19
Accepted  2014-03-20
DOI: 10.3969/j.issn.1674-8034.2014.03.001
DOI:10.3969/j.issn.1674-8034.2014.03.001.

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