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• Clinical Article •
Diffusion-weighted imaging at 3.0 T MR in diagnosis of lacrimal epithelial tumor
ZHANG He-huan  MU Xue-tao  WANG Hong 

DOI:10.3969/j.issn.1674-8034.2014.03.006.


[Abstract] Objective: To investigate the diagnostic value of diffusion-weighted imaging (DWI) at 3.0 T MR and apparent diffusion coefficient (ADC) in distinguishing benign and malignant lacrimal epithelial tumors.Materials and Methods: 42 patients with lacrimal epithelial tumor who underwent conventional MRI and diffusion weighted imaging at 3.0 T magnetic resonance system were retrospectively reviewed. All diagnoses were confirmed by surgery and pathologic examination including 17 cases of benign and 25 cases of malignant. The ADC values of 0 and 1000 s/mm2 were measured and analyzed statistically at the region with most significantly restricted diffusion. The ADC value of benign and malignant tumor was compared by Mann-Whitney U test, ROC curve of ADC value for diagnosing benign and malignant tumor was calculated.Results: The average ADC value of whole tumors was (0.965±0.191)×10-3 mm2/s, the average ADC values of benign and malignant tumor were (1.142±0.096)×10-3 mm2/sand (0.845±0.140)×10-3 mm2/s. There was statistical significant differences between the ADC values of benign and malignant tumors (Z=-4.754, P=0.000<0.01). The ADC value of malignant tumors at the region with most significantly restricted diffusion was lower than the ADC value of benign tumors. The acreage under the ROC curve was 0.936±0.043, S>0.9. The accuracy of ROC curve was high. According to ROC curve, using the ADC value of lower than 0.968×10-3 mm2/s as a threshold for diagnosing malignant lacrimal epithelial tumor, the sensitivity of diagnosis of malignant tumor was 92%, the specificity was 94%, the accuracy was 93% respectively.Conclusions: DWI at 3.0 T MR reveals the different diffusion characteristics of the lacrimal gland epithelial tumors. DWI could provide objective basis through the quantitative analysis of ADC values and be helpful in distinguishing benign and malignant lacrimal epithelial tumors.
[Keywords] Diffusion magnetic resonance imaging；Lacrimal Apparatus；Neoplasms

ZHANG He-huan Department of Graduate Institution, Xuzhou Medical College, Xuzhou 221004, China; Department of Magnetic Resonance Imaging, General Hospital of Armed Police Forces, Beijing 100039, China

MU Xue-tao Department of Magnetic Resonance Imaging, General Hospital of Armed Police Forces, Beijing 100039, China

WANG Hong* Department of Magnetic Resonance Imaging, General Hospital of Armed Police Forces, Beijing 100039, China

*Correspondence to: Wang H, E-mail: wanghongmri@sina.com

Conflicts of interest   None.

Received  2014-02-12
Accepted  2014-04-20
DOI: 10.3969/j.issn.1674-8034.2014.03.006
DOI:10.3969/j.issn.1674-8034.2014.03.006.

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