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• Technical Article •
Voxel-based morphometry MRI study of gray matter’s alteration in patients with chronic mountain sickness
LIU Cai-xia  BAO Hai-hua  LI Wei-xia  ZHAO Xi-peng  WU You-sen  ZHANG Hong-qian  WANG Li-hong 

DOI:10.3969/j.issn.1674-8034.2014.03.012.


[Abstract] Objective: The aim of the study was to investigate the gray matter (GM) volumes alterations in Chronic Mountain Sickness (CMS) patients by using voxel-based morphometry method (VBM) of magnetic resonance imaging (MRI).Materials and Methods: 14 cases of patients with clinically diagnosed CMS and age, sex, years of education, altitude matched 11 cases of normal volunteers underwent whole brain scan, and 3D-T1 structural images were acquired. Then we used the VBM method compared the whole brain GM differences between CMS group and normal controls.Results: Compared with the control group, increased GM volumes was found in the right lingual gyrus, right posterior cingulate, bilateral parahippocampa gyrus, left ilferior temporal gyrus in CMS group and we also found reduced GM volumes in left anterior cingulated.Conclusions: Based on magnetic resonance structural images, the VBM method could objectively display the volume changes of specific brain areas in CMS patients and revealed the impact of altitude hypoxia on brain structure from the perspective of imaging.
[Keywords] Anterior cruciate ligament；Ganglion, cyst；Magnetic resonance imaging

LIU Cai-xia Department of Radiology, Affiliated Hospital of Qinghai University, Xining 810001, China

BAO Hai-hua* Department of Radiology, Affiliated Hospital of Qinghai University, Xining 810001, China

LI Wei-xia Department of Radiology, Affiliated Hospital of Qinghai University, Xining 810001, China

ZHAO Xi-peng Department of Radiology, Affiliated Hospital of Qinghai University, Xining 810001, China

WU You-sen Department of Radiology, Affiliated Hospital of Qinghai University, Xining 810001, China

ZHANG Hong-qian Department of Radiology, Affiliated Hospital of Qinghai University, Xining 810001, China

WANG Li-hong Biomedical imaging Research Center, Tsinghua University Medical College, Beijing 100084, China

*Correspondence to: Bao HH, E-mail: baohelen@gmail.com

Conflicts of interest   None.

Received  2014-01-20
Accepted  2014-03-31
DOI: 10.3969/j.issn.1674-8034.2014.03.012
DOI:10.3969/j.issn.1674-8034.2014.03.012.

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