Share：
Share this content in WeChat
X
[Chinese][PDF]86186
• Review •
Functional magnetic resonance imaging of the lower spinal cord
JIA Yan-long  SHEN Zhi-wei  NIE Ting-ting  ZHANG Tao  YAN Gen  WU Ren-hua 

DOI:10.3969/j.issn.1674-8034.2014.03.016.


[Abstract] With functional magnetic resonance imaging (fMRI) technology widely used in the study of brain, spinal fMRI researches have also been gradually expanded. Presently, the spinal fMRI is mainly focused on cervical spinal cord and the articles of lower spinal cord is relatively few. The feasibility and effectiveness of lower spinal cord fMRI have been proven through studies of animal experiments and clinical basic trials. Moreover, following-up researches suggest that appropriate application of fMRI technology may have potential clinical value for the location of spinal cord function, therapeutic monitoring and treatment guidance. This paper reviewed the research progress on lower spinal cord (fMRI), and provided certain foundation for the further study in this filed.
[Keywords] spinal cord；Magnetic resonance imaging

JIA Yan-long Department of Medical Imaging, 2nd Affilicated Hospital, Shantou University Medical College, Shantou 515041, China

SHEN Zhi-wei Department of Medical Imaging, 2nd Affilicated Hospital, Shantou University Medical College, Shantou 515041, China

NIE Ting-ting Department of Medical Imaging, 2nd Affilicated Hospital, Shantou University Medical College, Shantou 515041, China

ZHANG Tao Department of Medical Imaging, 2nd Affilicated Hospital, Shantou University Medical College, Shantou 515041, China

YAN Gen Department of Medical Imaging, 2nd Affilicated Hospital, Shantou University Medical College, Shantou 515041, China

WU Ren-hua* Department of Medical Imaging, 2nd Affilicated Hospital, Shantou University Medical College, Shantou 515041, China; Provincial Key Laboratory of Medical Molecular Imaging, Guangdong, Medical College of Shantou University, Shantou 515041, China

*Correspondence to: Wu RH, E-mail: cjr.wurenhua@vip.163.com

Conflicts of interest   None.

Received  2013-12-27
Accepted  2014-01-30
DOI: 10.3969/j.issn.1674-8034.2014.03.016
DOI:10.3969/j.issn.1674-8034.2014.03.016.

[1]
Yoshizawa T, Nose T, Moore GJ, et al. Functional magnetic resonance imaging of motor activation in the human cervical spinal cord. NeuroImage, 1996, 4(3):174-182.
[2]
Harel NY, Strittmatter SM. Functional MRI and other non-invasive imaging technologies: Providing visual biomarkers for spinal cord structure and function after injury. Exp Neurol, 2008, 211(2): 324-328.
[3]
Stroman P, Krause V, Malisza K, et al. Extravascular proton-density changes as a non-BOLD component of contrast in fMRI of the human spinal cord. Magn Reson Med, 2002, 48(1): 122-127.
[4]
Ng MC, Wong KK, Li G, et al. Proton-density-weighted spinal fMRI with sensorimotor stimulation at 0.2 T. NeuroImage, 2006, 29(3):995-999.
[5]
戴建平,沈慧聪,李少武.磁共振脉冲序列在中枢神经系统中的应用(二).磁共振成像, 2010, 1(4): 305-310.
[6]
Zhao F, Williams M, Meng X, et al. BOLD and blood volume-weighted fMRI of rat lumbar spinal cord during non-noxious and noxious electrical hindpaw stimulation. NeuroImage, 2008, 40(1): 133-147.
[7]
Malisza KL, Stroman PW, Turner A, et al. Functional MRI of the rat lumbar spinal cord involving painful stimulation and the effect of peripheral joint mobilization. J Magn Reson Imaging, 2003, 18(2): 152-159.
[8]
Buritova J, Besson JM. Effects of flurbiprofen and its enantiomers on the spinal c-Fos protein expression induced by noxious heat stimuli in the anaesthetized rat. Eur J Pharmacol, 2000, 406(1): 59-67.
[9]
Endo T, Spenger C, Westman E, et al. Reorganization of sensory processing below the level of spinal cord injury as revealed by fMRI. Exp Neurol, 2008, 209(1): 155-160.
[10]
Majcher K, Tomanek B, Tuor UI, et al. Functional magnetic resonance imaging within the rat spinal cord following peripheral nerve injury. NeuroImage, 2007, 38(4): 669-676.
[11]
Jou IM. The effects from lumbar nerve root transection in rats on spinal somatosensory and motor-evoked potentials. Spine, 2004, 29(2): 147-155.
[12]
Lawrence J, Stroman PW, Bascaramurty S, et al. Correlation of functional activation in the rat spinal cord with neuronal activation detected by immunohistochemistry. NeuroImage, 2004, 22(4): 1802-1807.
[13]
Lilja J, Endo T, Hofstetter C, et al. Blood oxygenation level-dependent visualization of synaptic relay stations of sensory pathways along the neuroaxis in response to graded sensory stimulation of a limb. J Neurosci, 2006, 26(23): 6330-6336.
[14]
Stroman PW. Magnetic resonance imaging of neuronal function in the spinal cord: spinal FMRI. Clin Med Res, 2005, 3(3): 146-156.
[15]
Stroman P, Tomanek B, Krause V, et al. Mapping of neuronal function in the healthy and injured human spinal cord with spinal fMRI. NeuroImage, 2002, 17(4): 1854-1860.
[16]
Stroman P, Kornelsen J, Bergman A, et al. Noninvasive assessment of the injured human spinal cord by means of functional magnetic resonance imaging. Spinal cord, 2004, 42(2): 59-66.
[17]
Kornelsen J, Stroman P. fMRI of the lumbar spinal cord during a lower limb motor task. Magn Reson Med, 2004, 52(2): 411-414.
[18]
Borgens RB. Restoring function to the injured human spinal cord. Adv Anat Embryol Cell Biol, 2002, 171(III-IV): 1-155.
[19]
Kornelsen J, Stroman P. Detection of the neuronal activity occurring caudal to the site of spinal cord injury that is elicited during lower limb movement tasks. Spinal cord, 2007, 45(7): 485-490.
[20]
Bell EC, Willson MC, Wilman AH, et al. Differential effects of chronic lithium and valproate on brain activation in healthy volunteers. Hum Psycho Pharm Clin, 2005, 20(6): 415-424.
[21]
陈业晞,沈智威,肖叶玉,等.电针刺激穴位的脊髓fMRI初步研究.磁共振成像, 2010, 1(6): 438-441.
[22]
Govers N, Beghin J, Van Goethem J, et al. Functional MRI of the cervical spinal cord on 1.5 T with fingertapping: to what extent is it feasible? Neuroradiology, 2007, 49(1): 73-81.
[23]
Malisza KL, Jones C, Gruwel ML, et al. Functional magnetic resonance imaging of the spinal cord during sensory stimulation in diabetic rats. J Magn Reson Imaging, 2009, 30(2): 271-276.

PREV The application of magnetic resonance cell tracing technique in myocardial infarction cell transplantation treatment
NEXT MR imaging research present situation of HBV related liver cirrhosis nodules multi-step evolution and the latest progress
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn