Share：
Share this content in WeChat
X
[Chinese][PDF]105862
• Clinical Article •
Correlation on MRI non-morphological features and C-erbB-2 expression of breast cancer
WEI Wei  XIE Dong  SU Dan-ke  ZHANG Wei  ZHAO Xin  LUO Ning-bin 

DOI:10.3969/j.issn.1674-8034.2014.04.006.


[Abstract] Objective: To explore the correlations of MRI non-morphological features (hemodynamic performance and function characteristics) and C-erbB-2 of breast cancer.Materials and Methods: Seventy-seven patients diagnosed as breast cancers by pathologic examination were reviewed, analysis the MRI non-morphological features and the C-erbB-2 expression, to explore pathological changes of time-signal intensity curve, early intensive rate and ADC values, using t-test and chi-square test and Spearman rank correlation analysis with the correlation of C-erbB-2 expression.Results: The time-signal intensity curve of breast cancer, early intensive rate had no correlation with C-erbB-2 expression, ADC values had negative correlation with C-erbB-2 expression, ADC values differences between the groups of C-erbB-2 expression was statistically significant, the best threshold of ADC value to judgment C-erbB-2 expression was 0.988×10-3mm2/s by ROC curve.Conclusions: C-erbB-2 expression had no correlation with MRI hemodynamic performance indicators, had negative correlation with ADC values.
[Keywords] Breast neoplasms；Magnetic resonance imaging

WEI Wei Department of Radiology, the Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

XIE Dong Department of Radiology, the Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

SU Dan-ke Department of Radiology, the Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

ZHANG Wei Department of Radiology, the Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

ZHAO Xin Department of Radiology, the Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

LUO Ning-bin Department of Radiology, the Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China

Conflicts of interest   None.

Received  2014-03-19
Accepted  2014-05-10
DOI: 10.3969/j.issn.1674-8034.2014.04.006
DOI:10.3969/j.issn.1674-8034.2014.04.006.

[1]
杨玲,李连弟,陈育德,等.中国乳腺癌发病死亡趋势的估计与预测.中华肿瘤杂志, 2006, 28(6): 438-440.
[2]
汪登斌.乳腺MRI检查最佳序列选择及扫描参数优化.磁共振成像, 2011, 2(3): 177-181.
[3]
韦苇,黄仲奎,龙莉玲,等.乳腺浸润性导管癌的3.0 T MRI诊断.磁共振成像, 2012, 3(6): 434-439.
[4]
Orel SG, Schnall MD. MR imaging of the breast for the detection diagnosis, and staging of breast cancer. Radiology, 2001, 220(1): 13-30.
[5]
王跃华，王全红，李丽，等．乳腺癌Her-2基因检测方法对比研究．临床与实验病理学杂志, 2007, 23(2): 225-226.
[6]
Cooke T, Reeves J, Lannigan A, et al. The value of the human epidermal growth factor receptor-2 (HER-2) as a prognostic marker. Eur J Cancer, 2001, 37(Suppl 1): 3-l0.
[7]
李慧慧,马飞,曾瑄,等.乳腺癌HER-2的表达与临床病理特征的关系.中华医学杂志, 2011, 91(2): 76-80.
[8]
杨丽,时高峰,刘辉,等.乳腺癌磁共振特征与HER-2表达的相关性.肿瘤防治研究, 2013, 11(40): 1070-1073.
[9]
李艳玲,李洁,曹崑,等.乳腺癌动态增强MRI特征:非肿块样强化与肿块样强化的比较.中国医学影像技术, 2010, 26(7): 1258-1261.
[10]
Buadu LD, Murakami J, Murayama S, et al. Patterns of peripheral enhancement in breast masses: correlation of findings on contrast medium enhanced MRI with histologic features and tumor angiogenesis. J Comput Assist Tommogr, 1997, 21(3): 421-430.
[11]
朱萍,王亚非,黄昊,等. MR扩散加权成像表观扩散系数在乳腺结节病变诊断中的应用价值.中华放射学杂志, 2011, 45(12): 1117-1121.
[12]
高缇,张培功,姜兴岳,等.乳腺癌磁共振扩散加权成像与Her-2的相关性研究.中华临床医生杂志, 2012, 6(12): 3176-3179.

PREV The apparent diffusion coefficient measurement in diagnosis of axillary lymph node lesions with multi b values and optimizing b value
NEXT The feasibility of MRI to indicate protein expressions in primary breast cancer
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn