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• Clinical Article •
The feasibility of MRI to indicate protein expressions in primary breast cancer
FU Jiao-hui  CHANG Xiao-dan  WANG Ying-ying  YAO Chang-li 

DOI:10.3969/j.issn.1674-8034.2014.04.007.


[Abstract] Objective: By analying the relationship of MR images to the expressions of ER, PR, C-erbB-2, Ki-67, Topo II α, and discuss the possibility of MR images used to indicate the expressions of some proteins as biomarkers of breast cancers detected immunohistochemically.Materials and Methods: Retrospective analysis the MRI features of 156 primary breast cancer patients in China was performed. Morphologic and kinetic features of breast cancer in MRI were determined based on the breast imaging and reporting data system (BI-RADS). The expressions of estrogen receptor (ER), progesterone receptor (PR), C-erbB-2, Ki-67 and Topo II α were detected by immunohistochemistry. Pearson χ2 test and Spearman test were used to analyze the correlations of the MR features to these biomarkers.Results: Topo II α were often expressed in mass-like lesions. C-erbB-2 were often expressed in non-mass-like lesions, irregular shape lesions and homogenous enhancement lesions. PR were poorly expressed in rim enhancement lesions. C-erbB-2 were often expressed in the tumors with higher maximum signal enhancement ratio. Topo II α and Ki-67 were often expressed in the tumors with short time to peak.Conclusion: The present MR data might be expected to being useful in assessing the protein expression of primary breast cancer.
[Keywords] Breast neoplasms；Magnetic resonance imaging；Mlcular biology

FU Jiao-hui Deparment of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China

CHANG Xiao-dan* Deparment of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China

WANG Ying-ying Deparment of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China

YAO Chang-li Deparment of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China

*Correspondence to: Chang XD, E-mail: 13384111832@163.com

Conflicts of interest   None.

Received  2014-01-06
Accepted  2014-05-27
DOI: 10.3969/j.issn.1674-8034.2014.04.007
DOI:10.3969/j.issn.1674-8034.2014.04.007.

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