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Manganese-based contrast agents for MRI
ZENG Qing-bin  GUO Qian-ni  LUO Qing  WU Guang-yao  ZHOU Xin 

DOI:10.3969/j.issn.1674-8034.2014.04.016.


[Abstract] It is always a challenge to keep improving the contrast of MRI (magnetic resonance imaging) for different tissues and organs in order to detect diseases. Contrast agents, which can enhance the relaxation of protons in water, are usually used to overcome such issue. Gadolinium-based complexes are the most predominantly used contrast agents owing to its good enhancement effect on the relaxation time, but they may be caused a serious disease called nephrogenic systemic fibrosis (NSF), so they have a limited use in vivo. Manganese is a non-lanthanide paramagnetic metal, and possess a good enhancement effect on the relaxation due to five unpaired electrons of bivalent manganese. Manganese-based contrast agents include manganese salts, small organic chelates, macromolecule chelates, oxide nanopaticles and so on. Manganese has also play essential roles in cell biology and very low toxic in vivo, which enables the usage with a large dose in MRI. This paper reviews the recent applications and comments the future outlook of manganese-based contrast agents for MRI.
[Keywords] Magnetic resonance imaging；Contrast media；Manganese compounds

ZENG Qing-bin Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, the Chinese Academy of Sciences, Wuhan 430071, China

GUO Qian-ni Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, the Chinese Academy of Sciences, Wuhan 430071, China

LUO Qing Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, the Chinese Academy of Sciences, Wuhan 430071, China

WU Guang-yao Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, the Chinese Academy of Sciences, Wuhan 430071, China

ZHOU Xin* Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, the Chinese Academy of Sciences, Wuhan 430071, China

*Correspondence to: Zhou X, Email: xinzhou@wipm.ac.cn

Conflicts of interest   None.

Received  2014-02-27
Accepted  2014-05-08
DOI: 10.3969/j.issn.1674-8034.2014.04.016
DOI:10.3969/j.issn.1674-8034.2014.04.016.

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