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• Clinical Article •
The value of Enema Glycerine applying in preoperative MRI T1 staging and T2 staging of rectal cancer
LI Zhao-xiang  XUE Hua-dan  QIN Ming-wei  PAN Wei-dong 

DOI:10.3969/j.issn.1674-8034.2014.05.008.


[Abstract] Objective: To evaluate the value of Enema Glycerine applied in preoperative MRI T1 staging and T2 staging of rectal cancer.Materials and Methods: The MRI datum of 81 cases of pathologically confirmed T1 staging or T2 staging of rectal cancer suffers after operation (50 males and 31 females whose ages, 64.2±12.2 on average, range from 31 to 88), were collected retroactively, from september 2005 to december 2013, in PUMCH. Patients involved were examined by MRI within two weeks before the operation. In this study, 45 patients (30 males and 15 females) had used the Enema Glycerine. While the other 36 cases (21 males and 15 females) had no used it. So these cases were assigned to two groups. The thesis utilized Kappa test to analyze the consistency between the preoperative MRI T staging and the postoperative pathological staging of in each group, and calculated the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of the MRI T1 staging, T2 staging, and the the sensitivity of T1+T2 staging, and compared them, respectively.Results: Kappa tests (K=0.693 and K=0.537) showed the two groups, including applying the Enema Glycerine and no applying the Enema Glycerine, have good consistency of the preoperative MRI T staging and the postoperative pathological staging. Respectively, in the group applying the Enema Glycerine, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of the MRI T1 staging were 76.5%, 92.9%, 86.7%, 86.7% and 86.7%. Those of the MRI T2 staging were 78.6%, 76.5%, 86.7%, 84.5% and 68.4%. The sensitivity of the MRI T1+T2 staging was 77.8%. In the other group, no applying the Enema Glycerine, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of the MRI T1 staging were 57.1%, 95.5%, 80.6%, 88.9% and 77.8%. Those of the MRI T2 staging were 77.3%, 57.1%, 69.4%, 73.9% and 61.5%. The sensitivity of the MRI T1+T2 staging was 69.4%. The statistic analysis show the sensitivity of the MRI T1 staging, the specificity and the accuracy of MRI T2 staging of the group applying the Enema Glycerine were higher than that of the group no applying the Enema Glycerine (P<0.05, single-side hypothesis testing).Conclusions: There is higher value of Enema Glycerine, which can significantly improve the sensitivity of the preoperative MRI T1 staging, the specificity and accuracy of T2 staging, and simultaneously improve partly the diagnosis accuracy of the MRI T1 staging and T1+T2 staging, applied in preoperative MRI examination of rectal cancer and thus it should be one of the conventional application.
[Keywords] Enema Glycerine；Colorectal neoplasms；Magnetic resonance imaging；Neoplasm staging

LI Zhao-xiang Department of Radiology, Chinese Academy of Medical Sciences, Peking Union Medical College, Peking Union Medical College Hospital, Beijing 100730, China

XUE Hua-dan Department of Radiology, Chinese Academy of Medical Sciences, Peking Union Medical College, Peking Union Medical College Hospital, Beijing 100730, China

QIN Ming-wei* Department of Radiology, Chinese Academy of Medical Sciences, Peking Union Medical College, Peking Union Medical College Hospital, Beijing 100730, China

PAN Wei-dong Department of Radiology, Chinese Academy of Medical Sciences, Peking Union Medical College, Peking Union Medical College Hospital, Beijing 100730, China

*Correspondence to: Qin MW, E-mail: qinmingwei@hotmail.com

Conflicts of interest   None.

Received  2014-04-18
Accepted  2014-05-28
DOI: 10.3969/j.issn.1674-8034.2014.05.008
DOI:10.3969/j.issn.1674-8034.2014.05.008.

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