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• Clinical Article •
The value of diffusion-weighted MRI in the assessment of cervical cancer
HE Zhong-yun  FANG Xiang-jun  HUANG Liang  HE Wei-hong  GUO Gang  TIAN Qiang 

DOI:10.3969/j.issn.1674-8034.2014.05.010.


[Abstract] Objective: To investigate the potential value of diffusion weighted imaging (DWI) and the apparent diffusion coefficient (ADC) for staging and predicting short-term treatment response to nonsurgical therapy (chemo- and/or radiotherapy) of patients with cervical cancer.Materials and Methods: Sixty-eight patients with cervical cancer underwent DWI in addition to routine MR imaging at MRI before therapy. The staging accuracy by routine MRI sequences and routine MRI combined with DWI was compared with surgical specimens as the reference standard. All ADCs were calculated from b=0, 800 s/mm2 and the correlation between ADC and histologic stages of cervical cancer was evaluated. Thirty-eight patients were followed up after nonsurgical therapy and divided into complete response (CR) group and partial response (PR) group according to the results of follow-up. Difference of ADC between the two groups was compared with student’s t test.Results: (1) One stage Ib case of missed diagnosis occurred as routine MRI adopted and all cases of cervical cancer were found out by routine MRI combined with DWI. The accuracy of routine MRI for staging IIa was 85%and the combined use of routine MRI and DWI made accuracy 95%, yet there was not statistically significance between the two methods. (2) ADC value of each stage of cervical cancer was compared and no statistically significance was found (P>0.05). There was no correlation between ADC values and all stages. (3) The mean pre-therapy ADC value of CR group (n=25) and PR group (n=13) was 1.02×10-3 mm2/s and 1.14×10-3 mm2/s respectively. There was a statistically significant difference between the two groups (P<0.05).Conclusions: Routine MRI combined with DWI has high accuracy for detecting and staging of cervical cancer. ADC could predict short-term treatment response to nonsurgical therapy for patients with cervical cancer.
[Keywords] Cervix neoplasms；Diffusion magnetic resonance imaging

HE Zhong-yun Department of Radiology, No. 331 Hospital of Zhuzhou City, Hunan Province, Zhuzhou 412002, China

FANG Xiang-jun* Department of Radiology, The Second Hospital University of South China, Hengyang 421001, China

HUANG Liang Department of Radiology, The Second Hospital University of South China, Hengyang 421001, China

HE Wei-hong Department of Radiology, The Second Hospital University of South China, Hengyang 421001, China

GUO Gang Department of Radiology, The second hospital of Xiamen city, Fujian Province, Xiamen 361021, China

TIAN Qiang Department of Radiology, No. 331 Hospital of Zhuzhou City, Hunan Province, Zhuzhou 412002, China

*Correspondence to: Fang XJ, E-mail: fangxiangjun118@163.com

Conflicts of interest   None.

Received  2014-04-28
Accepted  2014-06-26
DOI: 10.3969/j.issn.1674-8034.2014.05.010
DOI:10.3969/j.issn.1674-8034.2014.05.010.

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