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• Original Article •
Differentiation of early cirrhosis from liver fibrosis: FA of DTI superior to ADC of DWI from the MRI findings in a rodent model study
CHEN Li-hua  LIU Ai-lian  MA Chun-mei  SONG Qing-wei  WANG He-qing  LIU Jing-hong  ZHANG Long-min  ZHAO Gang  WANG Yuan-yuan  GENG Xiao-ling 

DOI:10.3969/j.issn.1674-8034.2014.05.011.


[Abstract] Objective: To evaluate and compare the FA of DTI and the ADC of DWI in differentiating liver fibrosis and early liver cirrhosis in a rodent model study.Materials and Methods: This study was approved by the animal Ethics Committee in our hospital. 12 rodent models, including liver fibrosis (7 in total with 2 in grade II and 5 in grade III from pathologic exam) and cirrhosis (5 pathologically confirmed) ones, were established though periodical carbon tetrachloride (CCl4) injection to Wistar male rats with another 6 intact as the control. The MR exams were performed on a 1.5 T scanner (GE HDx, Mikauwee) using a wrist joint coil with the protocol including the routine T1WI, T2WI and DWI and DTI. For the objectiveness of comparison the scanning parameters were set basically identical for DWI and DTI, where FOV=16 cm×12 cm with a matrix of 192×128, slice thickness=3 mm and b=0, 500 s/mm2 with on 6 orthogonal directions applied for DTI. The MR images were blindly reviewed and analyzed by two experienced observers with the values of ADC and FA of the right liver lobe measured using the Functool on GE ADW 4.4 workstation. The ADC values of DWI and DTI, and FA values of DTI were statistically analyzed using software SPSS 13.0 with P<0.05 considered statistical significant.Results: A pounced trend in a decreasing manner was observed in the ADC values of both DWI and DTI from the control group to the liver fibrosis group, then to the early cirrhosis group. However, significant difference was only observed in the comparison of the control group respectively to the fibrosis and early cirrhosis groups (P<0.05), while not between the liver fibrosis and early cirrhosis groups. The FA values of DTI exhibited an increasing trend from the control to liver fibrosis, then to early liver cirrhosis groups, with statistically significant differences between each group observed (P<0.05).Conclusions: The FA of DTI showed a stronger capability than the ADC values of DWI and DTI in differentiating the early cirrhosis from liver fibrosis.
[Keywords] Liver cirrhosis；Magnetic resonance imaging

CHEN Li-hua Department of Radiology, The First Affiliated Hospital of DaLian Medical University, Dalian 116011, China

LIU Ai-lian* Department of Radiology, The First Affiliated Hospital of DaLian Medical University, Dalian 116011, China

MA Chun-mei Department of Radiology, The First Affiliated Hospital of DaLian Medical University, Dalian 116011, China

SONG Qing-wei Department of Radiology, The First Affiliated Hospital of DaLian Medical University, Dalian 116011, China

WANG He-qing Department of Radiology, The First Affiliated Hospital of DaLian Medical University, Dalian 116011, China

LIU Jing-hong Department of Radiology, The First Affiliated Hospital of DaLian Medical University, Dalian 116011, China

ZHANG Long-min Department of Radiology, The First Affiliated Hospital of DaLian Medical University, Dalian 116011, China

ZHAO Gang Department of Radiology, The First Affiliated Hospital of DaLian Medical University, Dalian 116011, China

WANG Yuan-yuan Department of Radiology, The First Affiliated Hospital of DaLian Medical University, Dalian 116011, China

GENG Xiao-ling Department of Radiology, The First Affiliated Hospital of DaLian Medical University, Dalian 116011, China

*Correspondence to: Liu AL, E-mail: cjr.liuailian@vip.163.com

Conflicts of interest   None.

Received  2014-05-07
Accepted  2014-07-26
DOI: 10.3969/j.issn.1674-8034.2014.05.011
DOI:10.3969/j.issn.1674-8034.2014.05.011.

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