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• Clinical Article •
Brain response to transcutaneous electronical stimulation on auricular concha of the healthy subjects using fMRI
FANG Ji-liang  HONG Yang  FAN Yang-yang  LIU Jun  MA Yun-yao  XU Chun-hua  WANG Hong-hong  MA Ying-ge  WANG Xiao-ling  LIU Zhi-shun  ZHU Bing  KONG Jian  RONG Pei-jing 

DOI:10.3969/j.issn.1674-8034.2014.06.003.


[Abstract] Objectives: To investigate the BOLD fMRI response to transcutaneous vagus nerve electronical stimulation (tVNS) at auricular concha region (ACR) on the healthy. It is hypothesized that tVNS modulates the network of nucleus of tract solitary-limbic system.Materials and Methods: Sixteen healthy subjects (18-27 y) were enrolled in the fMRI study. The fMRI was conducted during tVNS on ACR controlled with sham-tVNS on the superior scapha respectively. Subjects’ sensations were recorded after every fMRI scan. Each functional scan lasted 6 minutes. SPM8 was employed for the fMRI data processing.Results: The current, and the sensations' frequency and strength of electronical stimulation were similar between two groups. The tVNS induced the predominant deactivation in the left nucleus of tract solitary and brain regions involving in limbic function, and the activation was limited in left SII, left anterior insula, etc. However, the sham tVNS showed the deactivation in the areas of right nucleus of trigeminal nerve, the obvious activation in the somato-sensory areas.Conclusions: tVNS modulated the network of nucleus of tract solitary-limbic system. It would provide the basis of therapeutic mechanism of tVNS treating Depression.
[Keywords] Electronical acupuncture；Auricular concha region；Transcutaneous vagus nerve electronical stimulation；Functional magnetic resonance imaging；Brain activation；Negative brain deactivation

FANG Ji-liang Functional Brain imaging Lab, Department of Radiology, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

HONG Yang Functional Brain imaging Lab, Department of Radiology, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

FAN Yang-yang Functional Brain imaging Lab, Department of Radiology, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

LIU Jun Department of Acupuncture and Moxibustion, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

MA Yun-yao Functional Brain imaging Lab, Department of Radiology, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

XU Chun-hua Functional Brain imaging Lab, Department of Radiology, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

WANG Hong-hong Department of Acupuncture and Moxibustion, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

MA Ying-ge Huguosi Hospital, Beijing University of Chinese Medicine, Beijing 100035, China

WANG Xiao-ling Functional Brain imaging Lab, Department of Radiology, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

LIU Zhi-shun Department of Acupuncture and Moxibustion, Guang An Men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

ZHU Bing Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China

KONG Jian Martinos center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, MA02129, U S A

RONG Pei-jing * Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China

*Correspondence to: Rong PJ, E-mail: drpjrong@163.com

Conflicts of interest   None.

Received  2014-09-08
Accepted  2014-10-10
DOI: 10.3969/j.issn.1674-8034.2014.06.003
DOI:10.3969/j.issn.1674-8034.2014.06.003.

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