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• Clinical Article •
Functional connectivity study of the resting-state functional magnetic resonance imaging in nonlesional epilepsy
LIAO Da-wei  ZHANG Ti-jiang  JIANG Lin  WANG Ya-nan  ZHANG Guoming  LIU Heng  ZHU Ke-wen  PENG Lan 

DOI:10.3969/j.issn.1674-8034.2015.01.002.


[Abstract] Objective: To study the cerebral function change of nonlesional epilepsy (NLE) patients by resting state functional magnetic resonance imaging (rs-fMRI) amplitude of functional connectivity (FC) technique, discussing application value of FC for NLE. To improve the understanding of its pathophysiological mechanisms. Providing the reliable theoretical basis for the diagnosis and treatment of NLE.Materials and Methods: Forty-three patients and 46 sex-, age-, education level- and handedness-matched healthy volunteers were recruited for normal control group. Rs-fMRI was performed in all subjects by 3.0 T MR scanner. Then we analyzed FC. Two-sample t-test was used to compare the two groups. And correlation analysis was performed between FC statistical brain mapping and course of disease.Results: Compared with normal control group, in NLE patients, the increased FC of right Hippocampus (RH) was in the right superior temporal gyrus, left inferior temporal gyrus, right middle temporal gyrus, left middle temporal, right medial frontal gyrus, right middle frontal gyrus, left middle temporal gyrus, right middle frontal gyrus and left medial frontal gyrus. The increased FC of the left Hippocampus (LH) was in the right superior temporal gyrus, left superior temporal, left parahippocampa gyrus, left frontal lobe sub-gyral, right medial frontal gyrus, left inferior parietal lobule and right postcentral gyrus. Reduced FC of the RH was in the left genu of internal capsule, left inferior parietal lobule, right cingulate gyrus, left superior frontal gyrus, left frontal Sub-gyral. The reduced FC of the LH was in the right cerebellum posterior lobe, left ecrebellum anterior lobe, right superior temporal gyrus, right thalamus. In NLE patients, positive correlation between RH FC and course of disease was found in the left inferior frontal gyrus, left inferior temporal gyrus, left superior temporal gyrus, right frontal lobe sub-gyral, right precuneus, left parietal lobe sub-gyral, right inferior parietal lobule, left middle frontal gyrus. The positive correlation for LH FC was found in the left lingual gyrus, right middle frontal gyrus, left middle frontal gyrus, left inferior parietal lobule, right postcentral gyrus. The negative correlation of RH FC was found in the left nodule and left genu of internal capsule. The negative correlation of LH FC was found in the left cerebellar tonsi, left superior frontal gyrus, right superior temporal gyrus and left precuneus.Conclusions: ALFF and FC were non-invasive and effective brain functional research motheds, which can detect the resting state cerebral functional changes of NLE patients, and understand correlation with clinical variable (course of disease), provide a theoretical basis for pathophysiological mechanism in epilepsy.
[Keywords] Epilepsy；Brain diseases；Magnetic resonance imaging

LIAO Da-wei Department of Radiology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China; Department of Radiology, Affiliated Hospital of Lu Zhou Medical College, Luzhou 646000, China

ZHANG Ti-jiang* Department of Radiology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China

JIANG Lin Department of Radiology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China

WANG Ya-nan Department of Radiology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China

ZHANG Guoming Department of Radiology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China

LIU Heng Department of Radiology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China

ZHU Ke-wen Department of Radiology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China

PENG Lan Department of Radiology, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China

*Correspondence to: Zhang TJ, E-mail: tijzhang@163.com

Conflicts of interest   None.

Received  2014-03-21
Accepted  2014-06-09
DOI: 10.3969/j.issn.1674-8034.2015.01.002
DOI:10.3969/j.issn.1674-8034.2015.01.002.

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