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• Clinical Article •
Comparative study of local consistency with the resting state magnetic resonance imaging under first-episode depression
XIE Sheng-hui  NIU Guang-ming  GAO Yang  QIAO Peng-fei 

DOI:10.3969/j.issn.1674-8034.2015.01.003.


[Abstract] Objective: To explore the abnormal active area of brain function in patients with depression and the impact of depressive mood to the patient’s brain function using resting-state functional MRI(rfMRI) technology.Materials and Methods: 30 patients with depression [live up to DSM-IV diagnostic criteria for depression, Hamilton Depression Scale (HAMD-17) score≥17 points] and 30 healthy volunteers were examed by rfMRI. The difference between depression and normal control group was analyzed using the method of regional homogeneity (ReHo).Results: ReHo was significantly higher than the control group in the brain area of Bilateral part of the brain the amount of depression group, temporal, parietal, and bilateral putamen, right caudate nucleus, amygdala, cortex, cerebellar vermis, etc, while in the brain area of bilateral prefrontal cortex, precuneus, lingual gyrus and cerebellum, etc. reduced significantly (P <0.001, K>10) on ReHo chart analysis of depression group and normal control group.Conclusions: ReHo method can detect synchronised changes of regional cerebral tissue BOLD signal caused by depressed mood, more objectively reflect the functional state of the whole brain, thereby contribute to basic and clinical research of patients with depression.
[Keywords] Depression；Functional magnetic resonance imaging

XIE Sheng-hui Department of Magnatic Resonance Imaging, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China

NIU Guang-ming* Department of Magnatic Resonance Imaging, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China

GAO Yang Department of Magnatic Resonance Imaging, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China

QIAO Peng-fei Department of Magnatic Resonance Imaging, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China

*Correspondence to: Niu GM, E-mail: cjr.niuguangming@vip.163.com

Conflicts of interest   None.

Received  2014-05-09
Accepted  2014-08-10
DOI: 10.3969/j.issn.1674-8034.2015.01.003
DOI:10.3969/j.issn.1674-8034.2015.01.003.

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