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• Clinical Article •
The morphological study of brain cortical in chronic obstructive pulmonary disease
YANG Tian-he  LIN Jian-zhong  KANG Tai-shan  ZENG Qiang  WANG Jianteng  ZHANG Hai-yan  ZHANG Jia-xing 

DOI:10.3969/j.issn.1674-8034.2015.01.005.


[Abstract] Objective: In order to observe gray matter variation in patients with chronic obstructive pulmonary disease (COPD) via morphological analysis method of voxel-based morphometry (VBM) and FSL software.Materials and Methods: Twenty-five patients of COPD (patient group) and twenty-five volunteers matched with age, gender, cultural background and no history of neurologic or psychopathic disorders (control group) were recruited. All subjects were examined, including pulmonary function, mental state examination and blood gas. 3D T1WI of brain were performed on Siemens Verio 3.0 T MRI scanning. All the imaging were drawn to PC workstation and computed with software of FSL (cluster size reduced >70 voxel). Statistical analysis was performed using the general linear model to detect whole brain gray matter volume differences between the two groups.Results: Compared with the control group, the patients with COPD had markedly lower scores in the activities of daily life, the Mini-Mental State Examination, and Visual Reproduction, and Figure Memory tests. Statistical correlation between two groups showed significant gray matter volume loss in the regions of frontal lobe (bilateral orbital gyros, bilateral inferior frontal gyrus triangle), medial frontal gyrus, right anterior insular gyrus, and deep nuclei (P<0.01). According to the statistics of t value maximum voxels in coordinate of MNI, the Brodmann regions of the brain, which obviously atrophy, were mainly in 47 brain regions (superior frontal gyrus), the bilateral 13 brain regions (insular cortex), 22 brain regions (superior temporal gyrus), bilateral 32 and 24 brain regions.Conclusions: In COPD patients, the cortex volume of multiple brain areas can reduce, the damage regions mainly relate to bilateral prefrontal cortex, medial frontal gyrus, and right anterior insular gyrus. The regions of brain cortex injury are consistent with other diseases, such as obstructive sleep apnea, congenital central expiratory deficiency syndrome, and the cerebral injury of people living in high altitude areas.
[Keywords] Lung disease, obstructive；Cerebral cortex；Magnetic resonance imaging

YANG Tian-he Department of MRI, Affiliated Zhongshan Hospital of Xiamen University, Xiamen 361004, China

LIN Jian-zhong* Department of MRI, Affiliated Zhongshan Hospital of Xiamen University, Xiamen 361004, China

KANG Tai-shan Department of MRI, Affiliated Zhongshan Hospital of Xiamen University, Xiamen 361004, China

ZENG Qiang Department of MRI, Affiliated Zhongshan Hospital of Xiamen University, Xiamen 361004, China

WANG Jianteng Department of MRI, Affiliated Zhongshan Hospital of Xiamen University, Xiamen 361004, China

ZHANG Hai-yan Xiamen University, Xiamen 361005, China

ZHANG Jia-xing Xiamen University, Xiamen 361005, China

*Correspondence to: Lin JZ, E-mail: xmzshljz@163.com

Conflicts of interest   None.

Received  2014-03-13
Accepted  2014-06-30
DOI: 10.3969/j.issn.1674-8034.2015.01.005
DOI:10.3969/j.issn.1674-8034.2015.01.005.

[1]
Pauwels RA, Buist AS, Calverley PM, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med2001, 163 (5): 1256-1276.
[2]
Hung WW, Wisnivesky JP, Siu AL, et al. Cognitive decline among patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2009, 180(2): 134-137.
[3]
Kaptein AA, Scharloo M, Fischer MJ, et al. 50 years of psychological research on patients with COPD: road to ruin or highway to heaven? Respir Med, 2009, 103 (1): 3-11.
[4]
Finkelstein J, Cha E. Prevalence of sleep disturbances in COPD: a population-based study. Am J Respir Crit Care Med, 2010, 181(2): A6514.
[5]
蔡闯，钟南山．慢性阻塞性肺疾病与焦虑抑郁的关系．中华结核和呼吸杂志, 2007, 30 (1): 71-72.
[6]
Schneider C, Jick SS, Bothner U, et al. COPD and the risk of depression. Chest, 2010, 137 (2): 341-347.
[7]
Wagner PD, Dantzker DR, Dueck R, et al. Ventilation-perfusion inequality in chronic obstructive pulmonary disease. J Clin Invest, 1977, 59(2): 203-216.
[8]
Binks AP, Cunningham VJ, Adams L, et al. Gray matter blood flow change is unevenly distributed during moderate isocapnic hypoxia in humans. J Appl Physiol, 2008, 104(1): 212-217.
[9]
Ortapamuk H, Naldoken S. Brain perfusion abnormalities in chronic obstructive pulmonary disease: comparison with cognitive impairment. Ann Nucl Med, 2006, 20(2): 99-106.
[10]
Joo EY, Tae WS, Lee MJ, et al. Reduced brain gray matter concentration in patients with obstructive sleep apnea syndrome. Sleep, 2010, 33(2): 235-241.
[11]
Zhang J, Yan X, Shi J, et al. Structural modifications of the brain in acclimatization to high-altitude. PLoS One, 2010, 5(7): e11449.
[12]
Zhang J, Liu H, Yan X, et al. Minimal effects on human memory following long-term living at moderate altitude. High Alt Med Biol, 2011, 12(1): 37-43.
[13]
Liu ZB, Song NN, Geng WY, et al. Orexin-A and respiration in a rat model of smoke-induced chronic obstructive pulmonary disease. Clin Exp Pharmacol Physiol, 2010, 37(10): 963-968.
[14]
Teppema LJ, Dahan A. The ventilatory response to hypoxia in mammals: mechanisms, measurement, and analysis. Physiol Rev, 2010, 90(2): 675-754.
[15]
Borson S, Scanlan JM, Friedman S, et al. Modeling the impact of COPD on the brain. Int J Chron Obstruct Pulmon Dis, 2008, 3(3): 429-434.
[16]
Nagai M, Hoshide S, Kario K. The insular cortex and cardiovascular system: a new insight into the brain-heart axis. J Am Soc Hypertens, 2010, 4(4): 174-182.
[17]
张志强，许强，卢光明，等．失神性癫痫的动态功能MRI研究．磁共振成像, 2013, 4(1): 3-7.
[18]
Kumar R, Macey PM, Woo MA, et al. Diffusion tensor imaging demonstrates brainstem and cerebellar abnormalities in congenital central hypoventilation syndrome. Pediatr Res, 2008, 64(3): 275-280.
[19]
Fried I, Nenov VI, Ojemann SG, et al. Functional MR and PET imaging of rolandic and visual cortices for neurosurgical planning. J Neurosurg, 1995, 83(5): 854-861.
[20]
Macefield VG, Gandevia SC, Henderson LA. Neural sites involved in the sustained increase in muscle sympathetic nerve activity induced by inspiratory capacity apnea: a fMRI study. J Appl Physiol, 2006, 100(1): 266-273.
[21]
Tomaszewski Farias S, Cahn-Weiner DA, Harvey DJ, et al. Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adults. Clin Neuropsychol, 2009, 23(3): 446-461.
[22]
张若成，李春艳，杨兵，等．创伤后应激障碍的记忆损害与脑结构MRI特点探讨．磁共振成像, 2013, 4(6): 416-419.
[23]
Zanto TP, Rubens MT, Bollinger J, et al. Top-down modulation of visual feature processing: the role of the inferior frontal junction. Neuroimage, 2010, 53(2): 736-745.

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