Share：
Share this content in WeChat
X
[Chinese][PDF]105097
• Review •
Application and prospect of functional magnetic resonance imaging reveals changes in brain structure and function in depression
FANG Jun-fang  WANG Qian  WANG Bin  LI Xu-ri  MAO Ning 

DOI:10.3969/j.issn.1674-8034.2015.01.011.


[Abstract] Depression is a mood disorder that is caused by a variety of factors, its main manifestation is depression, pessimism, some even become suicidal. Studies have found that depression is due to the reduction of certain brain nerve connections and neurotransmitter. With the development of functional magnetic resonance imaging, more and more people apply functional magnetic resonance imaging to studying depression, in order to elucidate the mechanism. Compared with the traditional imaging method, it can respond to changes in brain white matter microstructure and function image corresponding brain regions, which is conducive to a more intuitive analysis of the relationship between structure and function of brain.
[Keywords] Depression；Brain diseases；Magnetic resonance imaging；Magnetic resonance spectroscopy

FANG Jun-fang Binzhou Medical University, Yantai 264003, China; Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264100, China

WANG Qian Binzhou Medical University, Yantai 264003, China; Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264100, China

WANG Bin* Binzhou Medical University, Yantai 264003, China; Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264100, China

LI Xu-ri Binzhou Medical University, Yantai 264003, China; Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264100, China

MAO Ning Binzhou Medical University, Yantai 264003, China; Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264100, China

*Correspondence to: Wang B, E-mail: binwang001 @aliyun.com

Conflicts of interest   None.

Received  2014-04-24
Accepted  2014-07-30
DOI: 10.3969/j.issn.1674-8034.2015.01.011
DOI:10.3969/j.issn.1674-8034.2015.01.011.

[1]
Greicius M, Krasnow B, Reiss AL, et a1．Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci, 2003, 100(1): 253-258.
[2]
李健，薛绍伟，王雪梅，等．基于局部一致性的脑静息功能模式偏侧化研究．磁共振成像, 2011, 2(2): 108-111.
[3]
Raichle ME, Snyder AZ. A default mode of brain function: a brief history of an evolving idea. Neuroimage, 2007, 37(4): 1083-1090.
[4]
姚志剑，王丽，卢青，等．静息态下抑郁症患者脑功能与临床症状的相关性．中国心理卫生杂志, 2009, 23(9): 680-684.
[5]
王丽，姚志剑，卢青，等．重度抑郁症症状缓解前后海马局部一致性研究．中国神经精神疾病杂志, 2010, 36(5): 264-267.
[6]
卢青，姚志剑，王丽，等．反复发作抑郁症患者治疗前后静息态脑功能成像变化的自身对照研究．中华行为医学与脑科学杂志, 2009, 18(12): 1097-1099.
[7]
Morris JS, Friston KJ, Büchel C, et al. A neuromodulatory role for the human amygdale in processing emotional facial expressions. Brain, 1998, 121 (Pt 1): 47-57.
[8]
李丽，丁妮，梅磊磊，等．基于功能磁共振成像方法的单相抑郁症情绪加工特点研究．高技术通讯, 2007, 17(12): 1301-1306.
[9]
胡治国，徐士勇，刘宏艳，等．非注意条件下抑郁症患者和健康个体对情绪词加工的不同脑激活模式．中华医学杂志, 2008, 88(5): 289-292.
[10]
曹燕翔，姚志剑，谢世平，等．男性重性抑郁症患者识别动态面部表情情绪偏向性的fMRI研究．中国心理卫生杂志, 2008, 22(4): 265-270.
[11]
姚志剑，杜经纶，谢世平，等．女性重性抑郁症患者识别动态面部表情的神经基础的fMRI研究．中国心理卫生杂志, 2008, 22(4): 258-264.
[12]
Brassen S, Braus DF, Weber-Fahr W, et al. Late-onset depression with mild cognitive deficits electrophysiological evidences for a preclinical dementia syndrome. Dement Geriatr Cogn Disord, 2004, l8(3-4): 271-2777.
[13]
Alexopoulos GS, Kiosses DN, Choi SJ, et al. Frontal white matter microstructure and treatment response of late-life depression: a preliminary study. Am J Psychiatry, 2002, 159(11): 1929-1932.
[14]
何雅娜，张权，张云亭，等．脑梗死后运动性失语患者语言中枢的fMRI评价．磁共振成像, 2010, 1(1): 6-10.
[15]
Aizenstein HJ, Andreescu C, Edelman KL, et al. fMRI correlates of white matter hyperintensities in late-life depression. Am J Psychiatry, 2011, 168(10): 1075-1082.
[16]
马林．重视基于体素的形态学测量学在脑结构变化评价中的应用.中华放射学杂志, 2011, 45(4): 325-326.
[17]
Grieve SM, Korgaonkar MS, Koslow SH, et al. Widespread reductions in gray matter volume in depression. Neuroimage Clin, 2013, 3: 332-339.
[18]
刘海霞，赵雯靖，邓伟，等．中年女性首发重性抑郁症患者基于体素的形态学MRI研究．第三军医大学学报, 2011, 33(23): 2516-2519.
[19]
张江华，肖晶，朱雪玲，等．首发抑郁症患者大脑灰质密度基于体素的形态测量学分析．中南大学学报, 2011, 36(4): 307-311.
[20]
Hayakawa YK, Sasaki H, Takao H, et al. Depressive symptoms and neuroanatomical structures in community-dwelling women: a combined voxel-based morphometry and diffusion tensor imaging study with tract-based spatial statistics. Neuroimage Clin, 2014, 4: 481-487.
[21]
Biedermann SV, Weber-Fahr W, Demirakca T, et al. 31P RINEPT MRSI and VBM reveal alterations in brain aging associated with major depression. Magn Reson Med, 2014. DOI:
[22]
Murphy CF, Gunning-Dixon FM, Hoptman MJ, et al. White-matter integrity predicts stroop performance in patients with geriatric depression. Biol Psychiatry, 2007, 61(8): 1007-1010.
[23]
刘想林，王玉忠，刘海洪，等．青年重性抑郁症患者弥散张量成像和静息状态下的功能磁共振成像．中南大学学报, 2010, 35(1): 25-31.
[24]
Aghajani M, Veer IM, Lang ND, et al. Altered white-matter architecture in treatment-naive adolescents with clinical depression. Psychol Med, 2013, 16: 1-12.
[25]
Jia Z, Wang Y, Huang X, et al. Impaired frontothalamic circuitry in suicidal patients with depression revealed by diffusion tensor imaging at 3.0 T. J Psychiatry Neurosci, 2013, 39(3): 170-177.
[26]
Aihara M, Ida I, Yuuki N, et al. HPA axis dysfunction in unmedicated major depressive disorder and its normalization by pharmacotherapy correlates with alteration of neural activity in prefrontal cortex and limbic/paralimbic regions. Psychiatry Res, 2007, 155(3): 245-256.
[27]
Song YJ, Korgaonkar MS, Armstrong LV, et al. Tractography of the brainstem in major depressive disorder using diffusion tensor imaging. PLoS One, 2014, 9(1): e84825.
[28]
Grieve SM, Korgaonkar MS, Etkin A, et al. Brain imaging predictors and the international study to predict optimized treatment for depression: study protocol for a randomized controlled trial. Trials, 2013, 14(1): 224.
[29]
Heutink J, Brouwer WH, de Jong BM, et al. Conscious and unconscious processing of fear after right amygdala damage: a single case ERP-study. Neurocase, 2011, 17(4): 297-312.
[30]
Alexopoulos GS, Kiosses DN, Choi SJ, et al. Frontal white matter microstructure and treatment response of late-life depression: a preliminary study. Am J Psychiatry, 2002, 159(11): 1929-1932.
[31]
Choi KS, Holtzheimer PE, Franco AR, et al. Reconciling variable findings of white matter integrity in major depressive disorder. Neuropsychopharmacology, 2014, 39(6):1332-1339.
[32]
林铮，李惠春，龚向阳，等．抑郁症患者前额叶，海马磁共振质子波谱成像的研究．中华精神科杂志, 2005, 38(4): 193-197.
[33]
Gabbay V, Hess DA, Liu S, et aI．Lateralized caudate metabolic abnormalities in addescent major depressive disorder: a proton MR spectroscopy study. Am J Psychiary, 2007, 164(12): 1881-1889.
[34]
陈峰，蒋湘玲，刘涛，等．老年抑郁症患者脑磁共振波普成像研究.中华精神科杂志, 2008, 41(4): 212-215.
[35]
邹可，孙学礼，黄晓琦，等．难治性抑郁症患者海马代谢的磁共振质子波普研究．中华精神科杂志, 2007, 40(2): 74-77.
[36]
郑华，王默力，段冬梅，等．氟西汀治疗首发抑郁症患者海马磁共振质子波谱变化的观察．中华保健医学杂志, 2010, 12(5): 376-379.
[37]
Lapidus KA1, Gabbay V2, Mao X3, et al. Lapidus KA, Gabbay V, Mao X, et al. In vivo 1H MRS study of potential associations between glutathione, oxidative stress and anhedonia in major depressive disorder. Neurosci Lett, 2014, 569: 74-79.
[38]
李子孝，戴建平，李少武，等. BOLD-fMRI和DTI：脑功能-结构结合的研究进展．国外医学临床放射学分册, 2006, 29(5): 308-310.

PREV Intraventricular gliosarcoma: unusual location of an uncommon tumor
NEXT The research progress of multimodality functional MRI in type 2 diabetic encephalopathy
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn